Cyanoacrylate glue reactions: A systematic review, cases, and proposed mechanisms

Athavale, Anand; Thao, Mai See; Sassaki, Viviane S; Lewis, Matthew; Chandra, Venita; Fukaya, Eri

doi:10.1016/j.jvsv.2023.03.018

Cited by 19 publications

(30 citation statements)

References 88 publications

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“…The most common reported adverse events were phlebitis, type IV hypersensitivity allergic reaction, foreignbody granuloma formation, and endovenous glue-induced thrombosis (EGIT). 8 Other reported complications included pigmentation, paraesthesia, ecchymosis, and glue protrusion from the skin. 8,18 Discussion CAC has been heavily marketed as a 'safe and effective' alternative treatment option to venous surgery and endovenous thermal ablative techniques of EVLA and RFA.…”

Section: Medical Literaturementioning

confidence: 99%

“…8 Other reported complications included pigmentation, paraesthesia, ecchymosis, and glue protrusion from the skin. 8,18 Discussion CAC has been heavily marketed as a 'safe and effective' alternative treatment option to venous surgery and endovenous thermal ablative techniques of EVLA and RFA. VenaSeal™ has been promoted as a simple outpatient procedure causing less pain and bruising, faster recovery times, no requirement for post-operative compression, and lasting results compared to thermal ablative methods.…”

Section: Medical Literaturementioning

confidence: 99%

“…[1][2][3][4] CAC has been promoted as 'superior' to venous surgery and endovenous thermal ablative procedures such as endovenous laser (EVLA) and radiofrequency ablation (RFA), with the promoters citing the benefits to include its non-reliance on post-treatment compression or the use of perivenous tumescent anaesthesia. 1,2,[5][6][7] Serious adverse events of this procedure were reported to be rare in the published trials 1,2,5,6,8 and tend to only appear in anecdotal case reports. [9][10][11][12][13][14][15][16][17][18] In contrast to thermal ablative procedures that produce a transmural vessel wall injury to ablate the target vein, 19 CAC aims to occlude the target vessel.…”

Section: Introductionmentioning

confidence: 99%

“…Hypersensitivity to n-BCA was cited as the key contraindication in the published trials. 1,2,5,6,8 n-BCA is a class of cyanoacrylates initially used as a skin adhesive to treat minor lacerations. The compound was subsequently used as an embolising agent in interventional treatment of vascular anomalies and tumours and as a haemostatic agent to manage bleeding.…”

Section: Introductionmentioning

confidence: 99%

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899 serious adverse events including 13 deaths, 7 strokes, 211 thromboembolic events, and 482 immune reactions: The untold story of cyanoacrylate adhesive closure

Parsi,

Zhang,

Whiteley

et al. 2023

Phlebology

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Objective The aim was to retrieve and analyse the serious adverse events of venous occlusion systems used in cyanoacrylate adhesive closure (CAC) submitted to regulatory agencies. Methods The Total Product Life Cycle (TPLC) database of the US Food and Drug Administration (FDA), the Database of Adverse Event Notifications (DAEN) of the Australian Therapeutic Goods Administration (TGA), and the Yellow Card database of the UK Medicines and Healthcare Products Regulatory Agency (MHRA) were reviewed. Three Freedom of Information (FOI) requests had to be submitted to the MHRA to obtain data. Results The TPLC contained 899 reports which included 13 cases of death, 7 strokes, 211 thromboembolic events, and 482 immune reactions. The DAEN recorded three reportable adverse events, and the MHRA recorded seven adverse incidents including one death. Conclusion CAC is associated with serious adverse events including death. These events are under-reported in the medical literature and only sub-optimally reported to the regulatory agencies.

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Section: Medical Literaturementioning

confidence: 99%

Section: Medical Literaturementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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899 serious adverse events including 13 deaths, 7 strokes, 211 thromboembolic events, and 482 immune reactions: The untold story of cyanoacrylate adhesive closure

Parsi,

Zhang,

Whiteley

et al. 2023

Phlebology

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“…[178][179][180] For adhesives used inside the human body with applications such as wound and leakage sealants, dental and orthopedic device fixation, or bioelectronic implants discussed before, postoperative complications occur due to immune responses of tissues to either the biomaterials [181,182] or adhesives. [183,184] In some cases, maintenance or failure of implants also requires replacement and postoperative revision. [185,186] These procedures first require the removal of adhesives before removing the implanted medical devices.…”

Section: Need For On-demand Removal Of Tissue Adhesivesmentioning

confidence: 99%

From Adhesion to Detachment: Strategies to Design Tissue‐Adhesive Hydrogels

Ho,

van Hilst,

Cui

et al. 2023

Advanced NanoBiomed Research

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The use of tissue adhesives dates to 1940s when surgical glues were introduced for wound closure applications. However, current clinically used tissue adhesives (fibrin and cyanoacrylate glues) have limited adhesion strength and biocompatibility issues which restrict their performance in targeted applications. Due to this unmet clinical challenge, there is a need to develop next‐generation tissue adhesives to expand the current limited available options. Another factor that is often overlooked in the field is the consequence of when these tissue adhesives fail while in use in specific applications. In this review, the complications arising from tissue adhesives that have insufficient adhesion strength are covered, where unintentional loosening and detachment can lead to serious complications depending on both the applications and scenarios in which the adhesives are used. Next, the current methodologies employed to design tissue‐adhesive hydrogels targeting specific applications are also collated. Finally, the different strategies to engineer on‐demand removal property of these tissue‐adhesive hydrogels are consolidated, including some perspectives on current challenges and outlooks in this field.

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Application of adhesives in the treatment of cartilage repair

Feng,

Ang,

Guan

et al. 2024

Interdisciplinary Medicine

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From degeneration causing intervertebral disc issues to trauma‐induced meniscus tears, diverse factors can injure the different types of cartilage. This review highlights adhesives as a promising and rapidly implemented repair strategy. Compared to traditional techniques such as sutures and wires, adhesives offer several advantages. Importantly, they seamlessly connect with the injured tissue, deliver bioactive substances directly to the repair site, and potentially alleviate secondary problems like inflammation or degeneration. This review delves into the cutting‐edge advancements in adhesive technology, specifically focusing on their effectiveness in cartilage injury treatment and their underlying mechanisms. We begin by exploring the material characteristics of adhesives used in cartilage tissue, focusing on essential aspects like adhesion, biocompatibility, and degradability. Subsequently, we investigate the various types of adhesives currently employed in this context. Our discussion then moves to the unique role adhesives play in addressing different cartilage injuries. Finally, we acknowledge the challenges currently faced by this promising technology.

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Cyanoacrylate glue reactions: A systematic review, cases, and proposed mechanisms

Cited by 19 publications

References 88 publications

899 serious adverse events including 13 deaths, 7 strokes, 211 thromboembolic events, and 482 immune reactions: The untold story of cyanoacrylate adhesive closure

899 serious adverse events including 13 deaths, 7 strokes, 211 thromboembolic events, and 482 immune reactions: The untold story of cyanoacrylate adhesive closure

From Adhesion to Detachment: Strategies to Design Tissue‐Adhesive Hydrogels

Application of adhesives in the treatment of cartilage repair

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