Cyanoacrylate Superglue to Treat Varicose Veins: Truly Office Based and Minimally Invasive?

Chan, Yiu Che; Ting, Acw; Yiu, Wai-ki; Cheng, Swk

doi:10.1016/j.ejvs.2012.11.005

Cited by 12 publications

(10 citation statements)

References 7 publications

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“…Kronik venöz yetmezlik ve varis tedavisinde endovenöz tedavi yöntemleri cerrahi travmalara maruz kalmadan minimal invaziv olmasına rağmen, anestezi için multipl perivenöz iğne enjeksiyonu prosedürel ağrı, ekimoz ve nöropatik hasarlara neden olabilmektedir. Ayrıca tüm escent anestezi uygulamak öğrenme eğrisinin en zor kısmıdır, zaman ve deneyim gerektirir (11,12…”

Section: Discussionunclassified

Siyanoakrilat ile Safen Ven Embolizasyonunda Ortalama Trombosit Hacmi ve Trombosit Sayısının Değişimi

Güven¹,

Doğukan²

2019

Harran Üniversitesi Tıp Fakültesi Dergisi

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272 Araştırma Makalesi / Research Article Öz. Amaç: Bu çalışmada amacımız kronik venöz yetmezlik ve varis tedavisinde siyanoakrilat (CA) ile yapılan safen ven embolizasyonunda işleme bağlı ortalama trombosit hacminin (MPV) ve trombosit sayısının değişimini saptamak ve oluşabilecek venöz tromboembolizm olaylarına açıklık getirmektir. Materyal ve Metot: Bu çalışmaya dâhil edilen 60 hasta Adıyaman Üniversitesi Tıp Fakültesi Kalp ve Damar Cerrahisine Polikliniğine başvuran varis ve kronik venöz yetersizliği olan hastalardan seçildi. CA ile safen ven embolizasyonu yapılan hastaların dosya taraması dijital ortamda yapılarak USG ve laboratuvar tetkikleri incelendi. İşlem yapılan toplam 437 hastadan işlem öncesi ve sonrası hemogram ve biyokimya tetkikleri alınan60hasta çalışmaya dahil edildi. Hastaların işlem öncesi ve sonrası trombosit sayısı ve ortalama trombosit hacmi değerlendirildi. Bulgular: Postoperatif(post-op) 1. Saat ve 1.ay MPV değeri preoperatif (pre-op) döneme göre anlamlı (p ˃ 0.05) değişim göstermezken post-op 3.gün MPV değeri pre-op döneme göre anlamlı (p ˂ 0.05) artış gösterdiği tespit edildi. Post-op 3.gün MPV değeri post op 1.saate göre anlamlı (p ˂ 0.05) artış ve post-op 1.ay MPV değeri post-op 3.güne göre anlamlı (p ˂ 0.05) düşüş göstermiştir. Sonuç: MPV işlemden 1 gün sonra normal değerlerden anlamlı artış göstermez iken post op 3. günde anlamlı artış gösterdi. MPV'ün artan trombojenite ile ilişkili olduğunu varsayarsak varis tedavisinde kullanılan minimal invaziv yöntemlerden olan CA ile safen ven embolizasyonu post-op erken (İlk bir hafta içinde) dönemde tromboembolik olaylara sebep olabilmektedir. AbstractBackground: In the present study, it is aimed to determine the intervention-related change in the mean platelet volume (MPV) and platelet count in saphenous vein embolization performed using cyanoacrylate in chronic venous stasis and varicose treatment, as well as explaining the possible venous thromboembolism events. Methods: 60 patients involved in the present study were selected from the patients, who had varicose and chronic venous stasis and who applied to the Cardiovascular Surgery Polyclinic of Medical Faculty of Adıyaman University. The files of patients undergone saphenous vein embolization using CA were performed digitally and their USG and laboratory results were analyzed. Among 437 patients, 60 patients' undergone hemogram and biochemical examination before and after the intervention were involved in the present study. The preoperative (pre-op) and postoperative (post-op) platelet counts and mean platelet volumes of the patients were analyzed. Results: When compared to the pre-op period, no significant change was observed on 1 st post-ophour and 1 st post-op month (p ˃ 0.05), however the MPV value observed on the 3 rd post-op day was significantly higher than the pre-op period (p ˂ 0.05). The MPV value observed on the 3 rd post-op day was statistically higher than on 1 st post-op hour (p ˂ 0.05) and the MPV value observed on the 1 st post-op month was statistically significantly lowe...

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Section: Discussionunclassified

Siyanoakrilat ile Safen Ven Embolizasyonunda Ortalama Trombosit Hacmi ve Trombosit Sayısının Değişimi

Güven¹,

Doğukan²

2019

Harran Üniversitesi Tıp Fakültesi Dergisi

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“…There are encouraging short term and preliminary reports on developing the application of cyanoacrylate adhesives for superficial venous disease of the lower limb. [17][18][19][20][21] It is being emphasized that using cyanoacrylate adhesive abolishes the necessity for tumescent anaesthesia and subsequently reduce the risk of thermally induced paraesthesia. In this respect, our findings concur with those till date.…”

Section: Discussionmentioning

confidence: 99%

Cyanoacrylate adhesive perforator embolization (CAPE) of incompetent perforating veins of the leg, a feasibility study

et al. 2014

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Consideration of treating incompetent perforating veins remains a conundrum based on scientific evidence available till date. While subfascial endoscopic perforator surgery (SEPS) proved to be a worthy alternative for open surgery, other even less invasive techniques were being introduced by the late nineties of the last century. Percutaneous thermo-ablation techniques are still being used today and seem more effective than non-thermal techniques. However, thermal techniques require anaesthesia and potentially may cause inadvertent damage to surrounding tissues such as nerves. Cyanoacrylate adhesive has a proven record, but not for the treatment of chronic venous disease of the leg. Innovation has led to the development of the VenaSeal® Sapheon Closure System which has been designed to use a modified cyanoacrylate glue as a new therapy for truncal vein incompetence. This paper explores the feasibility of ultrasound guided cyanoacrylate adhesive perforator embolization (CAPE). Results show a 76% occlusion rate of incompetent perforating veins without serious complications leading to the conclusion that further investigation with a dedicated delivery device in a larger patient population is warranted.

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“…Over the last 20 years, venous surgeons and companies researching new devices have largely concentrated on nonthermal alternatives to endovenous thermal ablation to remove the requirement for the injection of tumescent anaesthesia. Such techniques include foam sclerotherapy 15 , mechanochemical ablation (MOCA) 16 and cyanoacrylate glues 17 . However, probably because these all use the endovenous approach, none have proven to be disruptive to the dominance of endovenous thermoablation.…”

Section: Introductionmentioning

confidence: 99%

High intensity focused ultrasound (HIFU) for the treatment of varicose veins and venous leg ulcers – a new non-invasive procedure and a potentially disruptive technology

Whiteley

2019

Current Medical Research and Opinion

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Cyanoacrylate Superglue to Treat Varicose Veins: Truly Office Based and Minimally Invasive?

Cited by 12 publications

References 7 publications

Siyanoakrilat ile Safen Ven Embolizasyonunda Ortalama Trombosit Hacmi ve Trombosit Sayısının Değişimi

Siyanoakrilat ile Safen Ven Embolizasyonunda Ortalama Trombosit Hacmi ve Trombosit Sayısının Değişimi

Cyanoacrylate adhesive perforator embolization (CAPE) of incompetent perforating veins of the leg, a feasibility study

High intensity focused ultrasound (HIFU) for the treatment of varicose veins and venous leg ulcers – a new non-invasive procedure and a potentially disruptive technology

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