Cyanobacteria: an emerging source for drug discovery

Singh, Rahul; Tiwari, Shree Prakash; Kumar, Ashwani; Mohapatra, Tribhuban Mohan

doi:10.1038/ja.2011.21

Cited by 309 publications

(199 citation statements)

References 74 publications

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“…Currently, the ratio of cyanobacterial products has reached from practically 0 to 10%. 47 The sum of other eubacteriales products decreased from B20 to 10-12% (Table 3). The largest decrease occurred in actinobacterial products as their ratio decreased by 25%.…”

Section: The Present Situation Numbers Of Known Antibiotics and Naturmentioning

confidence: 98%

Thoughts and facts about antibiotics: Where we are now and where we are heading

Bérdy¹

2012

J Antibiot

923

557

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The declining trends in microbial metabolite and natural products research and the refocusing of this research area are discussed. Renewing natural products research requires inexhaustible natural resources, as well as new genetic techniques and microbial sources, including endophytic microbes. The numbers of known bioactive metabolites are summarized according to their microbiological origin, biological activities and chemical structures. Synthetic and natural product-based libraries are also compared. Importantly, the wide range of microbial metabolite bioactivities, future trends and the importance of prioritizing natural products over synthetic compounds are emphasized.

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Section: The Present Situation Numbers Of Known Antibiotics and Naturmentioning

confidence: 98%

Thoughts and facts about antibiotics: Where we are now and where we are heading

Bérdy¹

2012

J Antibiot

923

557

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“…Anabaenopeptins are circular peptides that inhibit various human proteases and protein phosphatases PP1/2A [63,64]. Cyanopeptolins are serine protease inhibitors that may be useful in treating viral infections and asthma [65]. Like MCs, these bioactive peptides are synthesized non-ribosomally, or by a combination of non-ribosomal and polyketide synthetic pathways.…”

Section: Miscellaneousmentioning

confidence: 99%

Cyanobacterial Toxins of the Laurentian Great Lakes, their Toxicological Effects, and Numerical Limits in Drinking Water

Miller

Beversdorf

Weirich

et al. 2017

Preprint

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Cyanobacteria are ubiquitous phototrophic bacteria that inhabit diverse environments across the planet. They dominate many eutrophic lakes impacted by excess nitrogen (N) and phosphorus (P) forming dense accumulations of biomass known as cyanobacterial harmful algal blooms or cyanoHABs. Their dominance in eutrophic lakes is attributed to a variety of unique adaptations including N and P concentrating mechanisms, N fixation, colony formation that inhibits predation, vertical movement via gas vesicles, and the production of toxic or otherwise bioactive molecules. While some of these molecules have been explored for their medicinal benefits, others are potent toxins harmful to humans, animals, and other wildlife known as cyanotoxins. In humans these cyanotoxins affect various tissues, including the liver, central and peripheral nervous system, kidneys, and reproductive organs among others. They induce acute effects at low doses in the parts-per-billion range and some are tumor promoters linked to chronic diseases such as liver and colorectal cancer. The occurrence of cyanoHABs and cyanotoxins in lakes presents challenges for maintaining safe recreational aquatic environments and the production of potable drinking water. CyanoHABs are a growing problem in the North American (Laurentian) Great Lakes basin. This review summarizes information on the occurrence of cyanoHABs in the Great Lakes, toxicological effects of cyanotoxins, and appropriate numerical limits on cyanotoxins in finished drinking water.

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“…65 (3): 890-899. Epub 2017 September 01.Key words: Synechococcales, extracts, mcyB, cyanobacteria.Cyanobacteria or blue-green algae are photosynthetic prokaryotes widely distributed in almost all habitats, from aquatic marine and freshwater ones to terrestrial environments, being also associated with various marine organisms such as corals and sponges (Glas et al, 2010;Paerl & Paul, 2011).In the last decades, cyanobacteria have been gaining attention in ecology, biochemistry, physiology and molecular biology, because of their high potential for antibiotics and pharmacologically active compounds production (Cardozo et al, 2007; Al-Wathnani, Ara, Thamaz, Al-Dayel, & Bakir, 2012 (Ehrenreich, Waterbury, & Webb, 2005;Singh, Tiwari, Rai, & Mohapatra, 2011;Costa et al, 2012). Among the toxins produced by cyanobacteria, the microcystins have been the most commonly found in blooms around the world, and they are produced by several cyanobacterial genera such as Microcystis, Anabaena, Nodularia, Oscillatoria, Nostoc, Cylindrospermopsis, Aphanizomenon, Planktothrix, Anabaenopsis, Synechocystis, Lyngbya, and others (Siqueira & Oliveira-Filho, 2005;Bortoli & Pinto, 2015).…”

mentioning

confidence: 99%

“…In the last decades, cyanobacteria have been gaining attention in ecology, biochemistry, physiology and molecular biology, because of their high potential for antibiotics and pharmacologically active compounds production (Cardozo et al, 2007; Al-Wathnani, Ara, Thamaz, Al-Dayel, & Bakir, 2012 (Ehrenreich, Waterbury, & Webb, 2005;Singh, Tiwari, Rai, & Mohapatra, 2011;Costa et al, 2012). Among the toxins produced by cyanobacteria, the microcystins have been the most commonly found in blooms around the world, and they are produced by several cyanobacterial genera such as Microcystis, Anabaena, Nodularia, Oscillatoria, Nostoc, Cylindrospermopsis, Aphanizomenon, Planktothrix, Anabaenopsis, Synechocystis, Lyngbya, and others (Siqueira & Oliveira-Filho, 2005;Bortoli & Pinto, 2015).…”

mentioning

confidence: 99%

“…The exploitation of natural cyanobacterial products can result in the discovery of new compounds (lipopeptides, amino acids, fatty acids, macrolides) with antiprotozoal, antiviral, antibacterial, antifungal, antitumoral, cytotoxic, and other biological activities (Ehrenreich, Waterbury, & Webb, 2005;Singh, Tiwari, Rai, & Mohapatra, 2011;Costa et al, 2012). Among the toxins produced by cyanobacteria, the microcystins have been the most commonly found in blooms around the world, and they are produced by several cyanobacterial genera such as Microcystis, Anabaena, Nodularia, Oscillatoria, Nostoc, Cylindrospermopsis, Aphanizomenon, Planktothrix, Anabaenopsis, Synechocystis, Lyngbya, and others (Siqueira & Oliveira-Filho, 2005;Bortoli & Pinto, 2015).…”

mentioning

confidence: 99%

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Microcystins production and antibacterial activity of cyanobacterial strains of Synechocystis, Synechococcus and Romeria isolated from water and coral reef organisms of Brazilian coast

Barboza

Gorlach‐Lira

Sassi

et al. 2017

RBT

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Cyanobacteria are widely distributed in terrestrial, freshwater and marine environments, and over the past decades have been recognized as a powerful source of bioactive compounds. In this study, some cyanobacterial strains were isolated from samples of seawater, brackish water and tissue of reef benthic invertebrates (zoanthid Protopalythoa variabilis, the sponges Cynachrella sp. and Haliclona sp., the coral Siderastrea stellata, and ascidians), collected at the states of Paraíba and Rio Grande do Norte (Northeast of Brazil), during the period between July 2010 and February 2014. After standard isolation methods, the cultivation of the strains was carried out in acclimatized culture chamber (25 °C) under constant aeration, for 15 days at 12-hour photoperiod, using Conway and BG11 media made with filtered seawater. The cyanobacterial cells were analysed for the microcystin production by the ELISA technique and their ethanolic and methanolic extracts for the antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa by the agar well diffusion method. The detection of the mcyB gene, one of the genes related to the microcystin synthesis, was done by the Polymerase Chain Reaction (PCR) technique. The majority of the eighteen cyanobacterial strains belonged to Synechococcaceae Family. The genera of Synechocystis, Synechococcus and Romeria were represented by ten, six and two strains, respectively. The production of microcystins was observed in five strains belonging to the genus Synechocystis. The presence of mcyB gene was detected in 12 strains of cyanobacteria: Synechocystis (three strains), Synechococcus (six strains) and Romeria (two strains). Only one strain (Synechocystis aquatilis) showed both the microcystin production and the mcyB gene presence. The antibacterial activity was observed for one strain of Romeria gracilis, one strain of Synechocystis aquatilis and two strains of Synechococcus sp. The ethanolic extracts of R. gracilis strain and two Synechococcus spp. strains inhibited the growth of P. aeruginosa. Among methanolic extracts of cyanobacteria, only one strain of S. aquatilis showed activity against S. aureus, and one R. gracilis strain against P. aeruginosa. Some cyanobacterial strains studied were positive for the microcystin production and antibacterial activity against pathogenic bacteria S. aureus and P. aeuruginosa, and may be further explored for additional biotechnological applications. Rev. Biol. Trop. 65 (3): 890-899. Epub 2017 September 01.Key words: Synechococcales, extracts, mcyB, cyanobacteria.Cyanobacteria or blue-green algae are photosynthetic prokaryotes widely distributed in almost all habitats, from aquatic marine and freshwater ones to terrestrial environments, being also associated with various marine organisms such as corals and sponges (Glas et al., 2010;Paerl & Paul, 2011).In the last decades, cyanobacteria have been gaining attention in ecology, biochemistry, physiology and molecular biology, because of their high potential for antibiotics and ...

show abstract

Cyanobacteria: an emerging source for drug discovery

Cited by 309 publications

References 74 publications

Thoughts and facts about antibiotics: Where we are now and where we are heading

Thoughts and facts about antibiotics: Where we are now and where we are heading

Cyanobacterial Toxins of the Laurentian Great Lakes, their Toxicological Effects, and Numerical Limits in Drinking Water

Microcystins production and antibacterial activity of cyanobacterial strains of Synechocystis, Synechococcus and Romeria isolated from water and coral reef organisms of Brazilian coast

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