Cyanobacteria-cyanophage interactions between freshwater and marine ecosystems based on large-scale cyanophage genomic analysis

Lin, Wei; Li, Dengfeng; Pan, Lingting; Li, Mengzhe; Tong, Yigang

doi:10.1016/j.scitotenv.2024.175201

Science of The Total Environment

2024

DOI: 10.1016/j.scitotenv.2024.175201

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Cyanobacteria-cyanophage interactions between freshwater and marine ecosystems based on large-scale cyanophage genomic analysis

Wei Lin,

Dengfeng Li,

Lingting Pan

et al.

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Cited by 2 publications

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Cyanophage-encoded auxiliary metabolic genes in modulating cyanobacterial metabolism and algal bloom dynamics

Ain,

Wu,

et al. 2024

Front. Virol.

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Cyanophages play a pivotal role in controlling cyanobacterial populations in aquatic environments. These dsDNA viruses harbor auxiliary metabolic genes (AMGs) that modulate the key metabolic processes of their cyanobacterial hosts, such as Photosynthesis, nutrient uptake for the optimization of viral replication. Recently, pan1~pan5 and pam1~pam5 cyanophages have been isolated from the fifth largest water resource in China; Lake Chaohu. Detailed genomic analysis of these phages revealed that these isolated cyanophages especially Pan1, Pam2 and Pam3 possess unique AMGs that significantly enhance the metabolic activities of their hosts, potentially leading to the suppression of bloom formation and stabilization of the ecological dynamics of Lake Chaohu. Our findings provide concrete evidence that cyanophages encoding AMGs could serve as effective biocontrol agents against harmful algal blooms, offering a targeted approach to manage these environmental threats. The integration of cyanophage-based management therapies with traditional methods could advance the efficiency and sustainability of controlling cyanobacterial outbreaks, paving the way for novel applications in water resource management. This review emphasizes the importance and critical need for further exploration of phage-host dynamics to fully harness the potential of cyanophages in ecosystem regulation.

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Cyanophage-encoded auxiliary metabolic genes in modulating cyanobacterial metabolism and algal bloom dynamics

Ain,

Wu,

et al. 2024

Front. Virol.

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Cyanophage Engineering for Algal Blooms Control

Guo,

Dong,

et al. 2024

Viruses

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Cyanobacteria represent a prevalent category of photosynthetic autotrophs capable of generating deleterious algal blooms, commonly known as cyanobacteria harmful algal blooms (cyanoHABs). These blooms often produce cyanotoxins, which pose risks to public health and ecosystems by contaminating surface waters and drinking water sources. Traditional treatment methods have limited effectiveness. Therefore, there is an urgent need for a new approach to effectively manage cyanoHABs. One promising approach is the use of cyanophages, which are viruses that specifically target cyanobacteria. Cyanophages serve as an effective biological control method for reducing cyanoHABs in aquatic systems. By engineering cyanophages, it is possible to develop a highly specific control strategy that minimally impacts non-target species and their propagation in the environment. This review explores the potential application of cyanophages as a strategy for controlling cyanoHABs. It includes the identification and isolation of broad-spectrum and novel cyanophages, with a specific focus on freshwater Microcystis cyanophages, highlighting their broad spectrum and high efficiency. Additionally, recent advancements in cyanophage engineering are discussed, including genome modification, functional gene identification, and the construction of artificial cyanophages. Furthermore, the current state of application is addressed. Cyanophage is a promising control strategy for effectively managing cyanoHABs in aquatic environments.

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Cyanobacteria-cyanophage interactions between freshwater and marine ecosystems based on large-scale cyanophage genomic analysis

Cited by 2 publications

References 81 publications

Cyanophage-encoded auxiliary metabolic genes in modulating cyanobacterial metabolism and algal bloom dynamics

Cyanophage-encoded auxiliary metabolic genes in modulating cyanobacterial metabolism and algal bloom dynamics

Cyanophage Engineering for Algal Blooms Control

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