2019
DOI: 10.1016/j.hal.2018.11.008
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Cyanobacterial bioactive metabolites—A review of their chemistry and biology

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Cited by 117 publications
(111 citation statements)
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References 541 publications
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“…A large number of biologically active secondary metabolite compounds have been isolated from Lamellodysidea herbacea sponges (reviewed in [79]), but distinguishing between those synthesized by the eukaryotic host versus microbial symbionts has proved challenging, especially in the absence of an assembled host genome. The unexpected discovery that the microbiomes of Lamellodysida herbacea clade Ia sponges contain representatives of the prolific secondary metabolite-producer genus Prochloron, in addition to Hormoscilla, provides new opportunities to identify microbial sources for both previously characterized and undiscovered natural product molecules.…”
Section: Discussionmentioning
confidence: 99%
“…A large number of biologically active secondary metabolite compounds have been isolated from Lamellodysidea herbacea sponges (reviewed in [79]), but distinguishing between those synthesized by the eukaryotic host versus microbial symbionts has proved challenging, especially in the absence of an assembled host genome. The unexpected discovery that the microbiomes of Lamellodysida herbacea clade Ia sponges contain representatives of the prolific secondary metabolite-producer genus Prochloron, in addition to Hormoscilla, provides new opportunities to identify microbial sources for both previously characterized and undiscovered natural product molecules.…”
Section: Discussionmentioning
confidence: 99%
“…There are a number of other cyanobacterial metabolites that occur in aquatic ecosystems in need of investigation concerning pathways of synthesis and toxicity. Overall, greater than 50 bioactive classes produced by cyanobacteria have been identified on the basis of their chemical properties (as reviewed by [108]. Besides the compounds already discussed in this review, the following molecules were attributed to freshwater cyanobacteria: aeruginosin, anabaenopeptin, cyanopeptolin, calothrixin, carmabin, microcyclamide, microginin, microguanidine, microviridin, and polymethoxy-1-alkenes.…”
Section: Future Research Prospectsmentioning
confidence: 91%
“…Cyanobacterial metabolites present cytotoxic, antimicrobial, antifungal, antiprotozoal, enzyme inhibiting, anti-inflammatory, dermatotoxic and neurotoxic activities that can also be exploited by the pharmaceutical industry to develop new drugs potentially beneficial to humans. [24][25][26] Future discoveries are likely to share structural similarities to previously discovered metabolites that may, however, exhibit differing potency and thus are critical to identify. Any modifications to the structure, such as replacement of amino acids by other residues, substitution by methylation, halogenation or oxidation and changes in configuration, can significantly affect the ability of cyanobacterial metabolites to evoke a biological response.…”
Section: Cyanopeptolins Cyclamidesmentioning
confidence: 99%