2014
DOI: 10.1099/mic.0.073478-0
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Cyanobacterial heat-shock response: role and regulation of molecular chaperones

Abstract: Cyanobacteria constitute a morphologically diverse group of oxygenic photoautotrophic microbes which range from unicellular to multicellular, and non-nitrogen-fixing to nitrogen-fixing types. Sustained long-term exposure to changing environmental conditions, during their three billion years of evolution, has presumably led to their adaptation to diverse ecological niches. The ability to maintain protein conformational homeostasis (folding-misfolding-refolding or aggregationdegradation) by molecular chaperones … Show more

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Cited by 62 publications
(36 citation statements)
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References 101 publications
(162 reference statements)
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“…Chaperones are known to mediate the correct assembly of several polypeptides [59]. In cyanobacteria, the heat-shock proteins GroEL and GroES are the most prominent chaperones, being up-regulated in a needbased manner [60]. The increased levels of GroES in Cu 2+ acute stress strongly suggest that this protein is involved in the mitigation of the metal toxic effects.…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…Chaperones are known to mediate the correct assembly of several polypeptides [59]. In cyanobacteria, the heat-shock proteins GroEL and GroES are the most prominent chaperones, being up-regulated in a needbased manner [60]. The increased levels of GroES in Cu 2+ acute stress strongly suggest that this protein is involved in the mitigation of the metal toxic effects.…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…The Mann group employed a spike-in stable isotope labeling with amino acids in cell culture approach to measure the changes of the yeast proteome under heat shock stress with nearly complete proteomic coverage (14). The proteomic perturbation reflected strong up-regulation of heat shock proteins and antioxidant proteins as well as suppressed translation-related functions, which are typical characteristics of HSR (15)(16)(17).…”
mentioning
confidence: 99%
“…Heat stress results in denaturation of proteins; therefore, a set of HSPs (groEL, 59 kDa and groES,10 kDa) in Anabaena is reported to maintain protein conformational homeostasis, conferring adaptability to stress (Rajaram et al, 2014). Heat shockmediated transcriptional activation of both groEL and groES in Ca 2+ -supplemented Anabaena cells suggested a possible role for Ca 2+ in stress adaptability of Anabaena PCC7120 by regulating expression of HSPs (ref.…”
Section: Discussionmentioning
confidence: 98%