Cyanobacterial metabolites as novel drug candidates in corona viral therapies: A review

Prabhu, S.; Vijayakumar, S.; Praseetha, Pabakaran

doi:10.1002/cdt3.11

Cited by 13 publications

(8 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, the antiviral medication currently available for these viruses has undesirable side effects. Under these conditions, it is imperative to consider new antiviral possibilities from natural sources, such as unprocessed extracts and cyanobacteria metabolites as discussed (Prabhu et al 2022 ). Hence, the researchers are trying to collect different kind of the compounds such as secondary metabolites from different solvent methods (such as methanol, water, and ethanol) using cyanobacteria to find the novel candidates against the viral diseases with the least side effects and complications in the later stage of the life (Prabhu et al 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Cyanometabolites: molecules with immense antiviral potential

et al. 2023

View full text Add to dashboard Cite

Cyanometabolites are active compounds derived from cyanobacteria that include small low molecular weight peptides, oligosaccharides, lectins, phenols, fatty acids, and alkaloids. Some of these compounds may pose a threat to human and environment. However, majority of them are known to have various health benefits with antiviral properties against pathogenic viruses including Human immunodeficiency virus (HIV), Ebola virus (EBOV), Herpes simplex virus (HSV), Influenza A virus (IAV) etc. Cyanometabolites classified as lectins include scytovirin (SVN), Oscillatoria agardhii agglutinin (OAAH), cyanovirin-N (CV-N), Microcystis viridis lectin (MVL), and microvirin (MVN) also possess a potent antiviral activity against viral diseases with unique properties to recognize different viral epitopes. Studies showed that a small linear peptide, microginin FR1, isolated from a water bloom of Microcystis species, inhibits angiotensin-converting enzyme (ACE), making it useful for the treatment of coronavirus disease 2019 (COVID-19). Our review provides an overview of the antiviral properties of cyanobacteria from the late 90s till now and emphasizes the significance of their metabolites in combating viral diseases, particularly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has received limited attention in previous publications. The enormous medicinal potential of cyanobacteria is also emphasized in this review, which justifies their use as a dietary supplement to fend off pandemics in future. Graphical abstract

show abstract

Section: Discussionmentioning

confidence: 99%

Cyanometabolites: molecules with immense antiviral potential

et al. 2023

View full text Add to dashboard Cite

show abstract

“…This valuable software was installed in Centos Linux, which served as the operating system for this docking research. Almost all the methods of computational drug design followed our previous publications (Kalaimathi et al 2021 ; Rani et al 2022 ; Prabhu et al 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Anti-dengue Potential of Mangiferin: Intricate Network of Dengue to Human Genes

Kalaimathi¹,

Rani

Vijayakumar

et al. 2022

Rev. Bras. Farmacogn.

View full text Add to dashboard Cite

Dengue fever has become one of the deadliest infectious diseases and requires the development of effective antiviral therapies. It is caused by members of the Flaviviridae family, which also cause various infections in humans, including dengue fever, tick-borne encephalitis, West Nile fever, and yellow fever. In addition, since 2019, dengue-endemic regions have been grappling with the public health and socio-economic impact of the ongoing coronavirus disease 19. Co-infections of coronavirus and dengue fever cause serious health complications for people who also have difficulty managing them. To identify the potentials of mangiferin, a molecular docking with various dengue virus proteins was performed. In addition, to understand the gene interactions between human and dengue genes, Cytoscape was used in this research. The Kyoto Encyclopedia of Genes and Genomes software was used to find the paths of Flaviviridae. The Kyoto Encyclopedia of Genes and Genomes and the Reactome Pathway Library were used to understand the biochemical processes involved. The present results show that mangiferin shows efficient docking scores and that it has good binding affinities with all docked proteins. The exact biological functions of type I interferon, such as interferon-α and interferon-β, were also shown in detail through the enrichment analysis of the signaling pathway. According to the docking results, it was concluded that mangiferin could be an effective drug against the complications of dengue virus 1, dengue virus 3, and non-structural protein 5. In addition, computational biological studies lead to the discovery of a new antiviral bioactive molecule and also to a deeper understanding of viral replication in the human body. Ultimately, the current research will be an important resource for those looking to use mangiferin as an anti-dengue drug. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s43450-022-00258-6.

show abstract

“…The diversity of unknown genes identified through ocean surveys (e.g., Sargasso Sea, Tara Oceans) represent the potential for new metabolic processes and biological molecules to be identified (Tara Ocean Foundation, Tara Oceans, European Molecular Biology Laboratory, 2022). Marine microbiomes have already been a source for bioprospecting resulting in the development of an algal-derived nasal spray that is effective against the SARS CoV-2 virus (Figueroa et al, 2021), and metabolites from cyanobacteria are being explored for treating viral infections and skin cancer (Prabhu et al, 2022). Following the initial discovery of the CRISPR/Cas system in bacteria and archaea, the CRISPR-Cas9 genome editing technique has significantly changed how some medical and agricultural research is carried out.…”

Section: Biodiscoverymentioning

confidence: 99%

Catalyzing progress in the blue economy through joint marine microbiome research across the Atlantic

Ortmann,

Goodwin,

Bolhuis

et al. 2023

Front. Mar. Sci.

View full text Add to dashboard Cite

International agreements recognize the importance of cooperative scientific research to conserve and promote sustainable development of a shared Atlantic Ocean. In 2022, the All-Atlantic Ocean Research and Innovation Alliance Declaration was signed. The All-Atlantic Declaration continues and extends relationships forged by the Galway Statement on Atlantic Ocean Cooperation and the Belém Statement on Atlantic Ocean Research and Innovation Cooperation. These efforts are consistent with programs, actions, and aims of the United Nations Decade of Ocean Science for Sustainable Development. In preparation for implementation of the All-Atlantic Declaration, members of the Marine Microbiome Working Group and the Marine Biotechnology Initiative for the Atlantic under the Galway and Belém Statements respectively, joined forces to call for cooperation across the Atlantic to increase marine microbiome and biotechnology research to promote ocean health and a sustainable bioeconomy. This article reviews the goals of the marine microbiome and biotechnology initiatives under the Galway and Belém Statements and outlines an approach to implement those goals under the All-Atlantic Declaration through a Blue Biotech and Marine Microbiome (BBAMM) collaboration.

show abstract

Cyanobacterial metabolites as novel drug candidates in corona viral therapies: A review

Cited by 13 publications

References 80 publications

Cyanometabolites: molecules with immense antiviral potential

Cyanometabolites: molecules with immense antiviral potential

Anti-dengue Potential of Mangiferin: Intricate Network of Dengue to Human Genes

Catalyzing progress in the blue economy through joint marine microbiome research across the Atlantic

Contact Info

Product

Resources

About