Cyanobacterial secondary metabolites mediate interspecies–intraspecies communication in the water body

Weiss, Gad; Sukenik, Assaf

doi:10.1111/1462-2920.12922

Cited by 8 publications

(10 citation statements)

References 20 publications

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“…These results indicate that microcystin biosynthesis genes in M. aeruginosa might be upregulated by a mechanism involving the direct presence of S. elongatus or, to a lesser extent, the presence of soluble compounds released into the medium by this cyanobacterium. Close communication of cyanobacteria with other members of the biosphere has been observed in several previous studies (Briand, Bormans, Gugger, Dorrestein, & Gerwick, ; Kaplan et al., , ). One possible means of interaction between co‐occurring microorganisms is through small molecules.…”

Section: Resultssupporting

confidence: 74%

“…Interaction of cyanobacteria with other members of the microbial community by means of secondary metabolites has been described and is an ongoing and expanding field of study (Kaplan, Weiss, & Sukenik, 2016;Kaplan et al, 2012). The picocyanobacterium Synechococcus elongatus is of particular interest in this context because it is almost ubiquitously distributed (Stockner, Callieri, & Cronberg, 2002).…”

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confidence: 99%

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Influence of cyanobacteria, mixotrophic flagellates, and virioplankton size fraction on transcription of microcystin synthesis genes in the toxic cyanobacterium Microcystis aeruginosa

et al. 2017

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Toxic cyanobacteria such as Microcystis aeruginosa are a worldwide concern in freshwater reservoirs. Problems associated with their mass occurrence are predicted to increase in the future due to global warming. The hepatotoxic secondary metabolite microcystin is of particular concern in this context. This study aimed to determine whether co‐occurring microorganisms influence the expression of microcystin biosynthesis genes. To this end, we performed cocultivation experiments and measured mcyB and mcyD transcripts in M. aeruginosa using RT‐qPCR. We utilized representatives from three different plankton groups: the picocyanobacterium Synechococcus elongatus, the unicellular flagellate grazer Ochromonas danica, and virioplankton from two different lakes. The presence of S. elongatus significantly increased mcyB and mcyD transcription in M. aeruginosa. Cocultivation with the mixotrophic chrysophyte O. danica did not increase the transcription of mcyB and mcyD; in fact, mcyD transcripts decreased significantly. The virioplankton size fraction of environmental water samples induced a significant increase in mcyB and mcyD transcription when obtained from lakes with cyanobacterial blooms. Our results show that co‐occurring microorganisms influence the expression of microcystin biosynthesis genes in M. aeruginosa.

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Section: Resultssupporting

confidence: 74%

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confidence: 99%

Influence of cyanobacteria, mixotrophic flagellates, and virioplankton size fraction on transcription of microcystin synthesis genes in the toxic cyanobacterium Microcystis aeruginosa

et al. 2017

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“…Although, secondary metabolites are generally accepted to play an important role in mediating interspecific communication among cyanobacteria (Kaplan et al ., ; ), their exact functional roles are still to be elucidated. Combining physiological and untargeted metabolomic approaches on co‐culturing cyanobacterial strains allowed to better understand underlying mechanisms due to interspecific interactions among cyanobacteria.…”

Section: Discussionmentioning

confidence: 99%

Chemically mediated interactions between Microcystis and Planktothrix: impact on their growth, morphology and metabolic profiles

Briand

Reubrecht

Mondeguer

et al. 2019

Environmental Microbiology

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Summary Freshwater cyanobacteria are known for their ability to produce bioactive compounds, some of which have been described as allelochemicals. Using a combined approach of co‐cultures and analyses of metabolic profiles, we investigated chemically mediated interactions between two cyanobacterial strains, Microcystis aeruginosa PCC 7806 and Planktothrix agardhii PCC 7805. More precisely, we evaluated changes in growth, morphology and metabolite production and release by both interacting species. Co‐culture of Microcystis with Planktothrix resulted in a reduction of the growth of Planktothrix together with a decrease of its trichome size and alterations in the morphology of its cells. The production of intracellular compounds by Planktothrix showed a slight decrease between monoculture and co‐culture conditions. Concerning Microcystis, the number of intracellular compounds was higher under co‐culture condition than under monoculture. Overall, Microcystis produced a lower number of intracellular compounds under monoculture than Planktothrix, and a higher number of intracellular compounds than Planktothrix under co‐culture condition. Our investigation did not allow us to identify specifically the compounds causing the observed physiological and morphological changes of Planktothrix cells. However, altogether, these results suggest that co‐culture induces specific compounds as a response by Microcystis to the presence of Planktothrix. Further studies should be undertaken for identification of such potential allelochemicals.

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“…Cyanobacteria produce an array of secondary metabolites, some of which are toxic to eukaryotes, that is, microcystins, cylindrospermopsin, anatoxin, saxotoxin and others. The biological role(s) of these secondary metabolites in the aquatic ecosystem is, in most cases, not clear and debatable (El-Sheekh et al, 2010;Alexova et al, 2011;Dziallas and Grossart, 2011;Gan et al, 2012;Makower et al, 2015;Meissner et al, 2015;Harke et al, 2016) but their involvement in interspecies and intraspecies communication is emerging (Bar-Yosef et al, 2010;Zilliges et al, 2011;Kaplan et al, 2015;Pearson et al, 2016;Omidi et al, 2018). There is a growing body of evidence that the secondary metabolites are info-chemicals involved in the communication between the cyanobacteria and their partnersbacteria, phytoplankton species and fungus that share the ecological niche.…”

Section: Introductionmentioning

confidence: 99%

“…There is a growing body of evidence that the secondary metabolites are info-chemicals involved in the communication between the cyanobacteria and their partnersbacteria, phytoplankton species and fungus that share the ecological niche. These communications have been described as 'languages spoken in the water body' (Kaplan et al, 2015). Naturally, the possibility of harnessing secondary metabolites to control toxic cyanobacterial and other algal blooms is appealing (Briand et al, 2016;Yu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Increased algicidal activity of Aeromonas veronii in response to Microcystis aeruginosa: interspecies crosstalk and secondary metabolites synergism

Weiss

Kovalerchick

Lieman-Hurwitz

et al. 2019

Environmental Microbiology

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Summary Toxic Microcystis spp. blooms constitute a serious threat to water quality worldwide. Aeromonas veronii was isolated from Microcystis sp. colonies collected in Lake Kinneret. Spent Aeromonas media inhibits the growth of Microcystis aeruginosa MGK isolated from Lake Kinneret. The inhibition was much stronger when Aeromonas growth medium contained spent media from MGK suggesting that Aeromonas recognized its presence and produced secondary metabolites that inhibit Microcystis growth. Fractionations of the crude extract and analyses of the active fractions identified several secondary metabolites including lumichrome in Aeromonas media. Application of lumichrome at concentrations as low as 4 nM severely inhibited Microcystis growth. Inactivation of aviH in the lumichrome biosynthetic pathway altered the lumichrome level in Aeromonas and the extent of MGK growth inhibition. Conversely, the initial lag in Aeromonas growth was significantly longer when provided with Microcystis spent media but Aeromonas was able to resume normal growth. The longer was pre‐exposure to Microcystis spent media the shorter was the lag phase in Aeromonas growth indicating the presence of, and acclimation to, secondary MGK metabolite(s) the nature of which was not revealed. Our study may help to control toxic Microcystis blooms taking advantage of chemical languages used in the interspecies communication.

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Cyanobacterial secondary metabolites mediate interspecies–intraspecies communication in the water body

Cited by 8 publications

References 20 publications

Influence of cyanobacteria, mixotrophic flagellates, and virioplankton size fraction on transcription of microcystin synthesis genes in the toxic cyanobacterium Microcystis aeruginosa

Influence of cyanobacteria, mixotrophic flagellates, and virioplankton size fraction on transcription of microcystin synthesis genes in the toxic cyanobacterium Microcystis aeruginosa

Chemically mediated interactions between Microcystis and Planktothrix: impact on their growth, morphology and metabolic profiles

Increased algicidal activity of Aeromonas veronii in response to Microcystis aeruginosa: interspecies crosstalk and secondary metabolites synergism

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