Females prefer discovering social media or healthcare systems to finding information and presenting their cases with any physician; however, the behavior of physicians tends to be uncontrollable on the healthcare system. Physicians have the capacity to share all of their patients' information with their colleagues without any permission or concern from the patients. For this reason, it is of utmost importance to design a breast self-examination system that can keep monthly track of self-exam data and communication between patient and physician. To develop such a system, identify the ethical values and trustworthiness as an indicator. Then, the survey will provide the details on ethical values and trustworthiness applicable in the system. Therefore, this research objective on the importance of ethical value and trustworthiness in the healthcare system. The survey on 772 respondents leading to the importance of the ethical value being used in the healthcare system is required. The ethical value of interaction, integrity, confidentiality, protection, caring, and fairness have a significant influence on the healthcare system. The path coefficients are answering Hypothesis I in presenting the positive relationship and significant effect between ethical value and BSE system (P<.001). On the other side, trustworthiness has a significant influence on the healthcare system. The path coefficients are answering Hypothesis II in presenting the positive relationship and significant effect between trustworthiness and the BSE system (P<.001). Finally, the relationship in healthcare between trustworthiness and ethical value is on integrity with honesty and belief.