2013
DOI: 10.5336/medsci.2012-32233
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Cyberknife® Radiosurgery and Fractionated Stereotactic Radiotherapy For Brainstem or Adjacent-to-Brainstem Metastases

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(4 citation statements)
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“…The 1-year OS was 33% (95% CI, 30%-37%; I 2 = 35%; P = .04; Figure 1D) in 1254 patients across 27 studies, and the 2-year OS was 13% (95% CI, 11%-16%; I 2 = 30%; P = .10; eFigure 8 in Supplement 2) in 959 patients across 22 studies. Death attributed to BSM progression was rare (19 of 703 [2.7%] deaths across 19 studies).…”
Section: Resultsmentioning
confidence: 98%
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“…The 1-year OS was 33% (95% CI, 30%-37%; I 2 = 35%; P = .04; Figure 1D) in 1254 patients across 27 studies, and the 2-year OS was 13% (95% CI, 11%-16%; I 2 = 30%; P = .10; eFigure 8 in Supplement 2) in 959 patients across 22 studies. Death attributed to BSM progression was rare (19 of 703 [2.7%] deaths across 19 studies).…”
Section: Resultsmentioning
confidence: 98%
“…The 1-year LC was 86% (95% CI, 83%-88%; I 2 = 38%; P = .12 for heterogeneity; Figure 1A) in 1410 patients across 31 studies, the ORR was 59% (95% CI, 47%-71%; I 2 = 88%; P < .001; Figure 1B) in 642 patients across 17 studies (eFigure 3A in Supplement 2), and the rate of symptom improvement was 55% (95% CI, 47%-63%; I 2 = 41%; P = .06; Figure 1C) in 323 patients across 13 studies. Prior or concurrent WBRT (coefficient, −1.90; Q M = 5.26; P = .02), or symptomatic BSM (coefficient, −2.43; Q M = 5.11; P = .02) were associated with decreased ORR.…”
Section: Resultsmentioning
confidence: 99%
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