Cyberknife Radiosurgery for Synovial Sarcoma Metastasizing to the Spine: Illustrative Case Reports

Abstract

Synovial sarcoma (SS) is a rare and aggressive type of soft tissue sarcoma that commonly affects young adults. Metastasis in the spine is a rare complication, and the management of these lesions is challenging. Radiosurgery is an increasingly popular treatment option for spinal metastasis due to its ability to deliver high doses of radiation to the target volume with minimal exposure to surrounding healthy tissues. In this paper, we present two cases of SS with spinal metastasis that were treated with CyberKnife radiosurgery (CKRS). The first case was a 52-year-old female with a history of multiple thoracotomies and lobectomies for lung metastases, who was diagnosed with T6-T8 and T4 spinal metastasis. The second case was a 53-yearold female with Down syndrome, who was diagnosed with T12-L1 spinal metastasis. Both patients experienced an improvement in their symptoms following CKRS treatment and showed stable or decreasing lesion sizes on follow-up imaging. The progression-free survival (PFS) in the first case was 37 months and overall survival (OS) was 79 months. In the second case, the PFS was 12 months and OS was 18 months. These cases highlight the potential benefits of CKRS as a treatment option for SS with spinal metastasis and support its use in the management of this challenging condition.

The Expanding Role of ChatGPT (Chat-Generative Pre-Trained Transformer) in Neurosurgery: A Systematic Review of Literature and Conceptual Framework

“…Furthermore, the tool was explored in practical neurosurgery for research and patient care, raising ethical questions and discussing its limitations while emphasizing the importance of human verification [22,23]. Various case reports demonstrated ChatGPT's role in analyzing and reporting on specific medical cases, such as papers by Zamarud et al [3] and Montagne et al [4]. The tool showcased its potential in enhancing medical case reporting and study data analysis.…”

“…ChatGPT, as an AI language model, utilizes deep learning to generate human-like responses to natural language queries. Its potential to enhance medical practice, such as improving surgical planning, analyzing imaging data, and manuscript writing across various medical disciplines, including neurosurgery, is noteworthy but has yet to be heedfully analyzed [3][4][5].…”