CyberKnife radiotherapy for orbital metastases: A single-center experience on 24 lesions

Riva, Giulia; Augugliaro, Matteo; Piperno, Gaia; Ferrari, Annamaria; Rondi, E.; Vigorito, S.; Ciardo, D.; Orecchia, Roberto; Jereczek‐Fossa, Barbara Alicja

doi:10.1177/1120672118761728

Cited by 8 publications

(7 citation statements)

References 32 publications

(52 reference statements)

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“…Local disease control and palliation of symptoms was achieved in all patients using a median dose of 18 Gy (15-24 Gy) given in a median of three fractions (2-3 fractions) performed each other day. 3 We reported a partial response in a patient with intraocular breast cancer metastases. Mexico's health care institutions agree that legal blindness is defined as visual acuity of 20/200 or worse and our case presented with OD visual acuity of 20/400.…”

Section: Discussionmentioning

confidence: 89%

“…2 Due to an improvement in survival among cancer patients and improvements in radiological imaging, the diagnosis of intraocular metastases appears to be increasing. 3 Patients' symptoms vary according to size and location of the tumor, most presented with visual loss, floaters, photopsia or diplopia, affecting significantly their quality of life. https://doi.org/10.1016/j.rpor.2019.10.001 1507-1367/© 2019 Greater Poland Cancer Centre.…”

Section: Introductionmentioning

confidence: 99%

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Frameless radiosurgery for intraocular metastatic tumor: Case report

Cárdenas¹,

Penella

Ibarra³

2020

Reports of Practical Oncology & Radiotherapy

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The aim of this case report is to describe the technique and response using frameless radiosurgery technique in intraocular metastases.Background: Intraocular metastases are the most common malignant lesion within the eye and its prevalence is probably underestimated. This is of great interest for oncologist as there are new treatment options with high rates of tumor control maintaining patient's quality of life.Case Report: We report a case of a 54-year-old female with intraocular metastases from breast cancer using a frameless radiosurgery technique allowing organ preservation. Conclusion:The frameless robotic radiosurgery system is feasible and comfortable option for patients with intraocular metastases. Treatment planning and delivery requires an experienced interdisciplinary team.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Frameless radiosurgery for intraocular metastatic tumor: Case report

Cárdenas¹,

Penella

Ibarra³

2020

Reports of Practical Oncology & Radiotherapy

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“…Grade 1 acute toxicities were reported in 33% cases of irradiated tumors, and the most frequently reported ones include: conjunctival erythema (75%), epiphora (37%), and superior palpebral oedema (25%). No grade 2 toxicities were reported and only 1 patient developed a long-term adverse event, ipsilateral cataract (10).…”

Section: Discussionmentioning

confidence: 97%

"Approach to Treatment for Breast Cancer Metastasis To the Orbit: Case Report "

Radu¹,

Băncilă²

2022

JMRO

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"Breast cancer is the most common cancer worldwide and, despite its well-known ability to spread to multiple anatomic sites, orbital metastases are considered an exceptional event. We present the case of a 53-year-old woman who was diagnosed with luminal B cT4cN1M1 breast cancer with lung metastases (M1PUL) and bone metastases (M1OSS) and was treated with palliative chemotherapy, zoledronic acid, and hormonotherapy with no significant benefit (progressive disease). Two years after the diagnosis, the patient complained of right eye proptosis, local pain and decrease in visual acuity. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a soft tissue mass in the right orbit, extending along the right optic nerve, but not invading it. A multidisciplinary team determined that the best next therapeutic step is orbital palliative radiotherapy. Stereotactic body radiation therapy (SBRT) was used because of the location of the metastasis and the high risk of vision loss. Proptosis and local pain were resolved two months after palliative SBRT and an imaging partial response was obtained. "

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“…IMRT is an effective treatment enabling the precise and intensive irradiation of tumor tissues by calculating the radiation dose [9]. By combining two-dimensional information obtained from multimodal ophthalmic imaging with three-dimensional information obtained from MRI, difficult-to-treat lesions near the macula and optic nerve head can be managed by controlling the irradiation area.…”

Section: Discussionmentioning

confidence: 99%

“…IMRT uses multiple fields, typically five to nine, and modulates the radiation dose distribution using a multileaf collimator. The results are complex concave dose distributions providing greater precision and better conformality to the tumor volume than conventional EBRT by reducing the radiation to the surrounding tissues and targeting only the tumor [8,9]. We report a case of multiple metastatic choroidal tumor lesions located near the macula and optic disc in a breast cancer patient treated with IMRT.…”

Section: Introductionmentioning

confidence: 99%

Intensity-Modulated Radiation Therapy for Bilateral Choroidal Metastases Involving Macula and Optic Disc

Kubo,

Hashida,

Watanabe

et al. 2023

Cureus

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This case report discusses the case of a 76-year-old woman with choroidal metastasis from breast cancer who was treated with intensity-modulated radiation therapy (IMRT). Choroidal metastasis is a common ocular tumor, and the occurrence of this condition has increased due to improved diagnostic tools and longer survival of metastatic patients. IMRT is an innovative radiation therapy technique that reduces complications and improves the curative effect by concentrating radiation on the tumor while minimizing exposure to surrounding tissues. In this case, the patient had a history of breast cancer and was undergoing chemotherapy when she presented with vision loss and blurred vision. Imaging tests confirmed choroidal metastasis, and IMRT was performed under the guidance of a radiation oncologist. After treatment, the choroidal lesion dramatically reduced in size, and the patient's vision improved. The text concludes that radiation therapy, including IMRT, is becoming more common as a treatment for ocular metastasis to improve vision and preserve the eye. When choosing radiation therapy, it is essential to consider the size of the tumor and the impact on surrounding tissues. IMRT is an effective treatment that enables precise and concentrated irradiation of the tumor tissue while minimizing exposure to normal tissues.

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CyberKnife radiotherapy for orbital metastases: A single-center experience on 24 lesions

Abstract: In our experience, CyberKnife-SRT is a well-tolerated treatment that offers high local and symptom control in patients with intraocular and periocular malignant lesions.

Cited by 8 publications

References 32 publications

Frameless radiosurgery for intraocular metastatic tumor: Case report

Frameless radiosurgery for intraocular metastatic tumor: Case report

"Approach to Treatment for Breast Cancer Metastasis To the Orbit: Case Report "

Intensity-Modulated Radiation Therapy for Bilateral Choroidal Metastases Involving Macula and Optic Disc

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