Cyclic Adenosine 3′,5′‐monophosphate Content and Bronchial Smooth Muscle Contractility of Hyper‐ and Hypothyroid Lungs

Nabishah, B. M.; Morat, Paden; Alias, A. K.; Kadir, B. A.; Khalid, B. A. K.

doi:10.1111/j.1440-1681.1992.tb00423.x

“…Though clinical technology develops fast, the high morbidity and mortality of sepsis is still a major problem [6,7]. Previous studies have shown that septic lung injury can lead to the interaction of cAMP and various hormone levels, resulting in changes in lung tissue structure [8][9][10][11][12]. In this study, the survival rate of 40 SD rats was studied through the CLP sepsis model.…”

Section: Discussionmentioning

confidence: 99%

Endogenous Sulfur Dioxide Improves the Survival Rate of Sepsis by Improving the Oxidative Stress Response during Lung Injury

Liu

¹

,

Gao

²

,

Ye

³

et al. 2022

Oxidative Medicine and Cellular Longevity

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Objective. To explore the regulation of endogenous sulfur dioxide on oxidative stress in lung injury induced by sepsis. Method. Forty male Sprague Dawley rats were divided into control, sepsis, sepsis + SO2, and SO2 group randomly used to observe survival rate. The other group of twenty-eight rats were randomly divided as the same manner for mechanism research. The number of WBCS and the percentage of PMN cells were calculated. The microphotographs of morphological changes and the index of quantitative assessment (IQA) of lung tissues were calculated. The ratio of wet/dry (W/D) of lung tissues was calculated. Levels of H2O2, MDA, NO, MPO, SOD, GSH-px, and TNF-α in plasma and lung tissues were measured. Result. The number of WBCS and the percentage of PMN cells decreased in sepsis ( p all < 0.05), and rebound in sepsis+SO2 ( p all < 0.05). The IQA and W/D of lung tissues increased in sepsis ( p for W / D < 0.05 ), and decreased in sepsis+SO2 ( p all < 0.05). H2O2 and MDA of plasma and lung tissues increased in sepsis ( p all < 0.05) and rebound in sepsis+SO2 ( p for H2O2 of plasma and lung tissues <0.05). NO and MPO of plasma and lung tissues increased in sepsis ( p for NO and MPO of lung tissues <0.05) and rebound in sepsis+SO2 ( p all < 0.05 ). SOD of plasma and lung tissues in sepsis group decreased ( p all <0.05) and increased in sepsis+SO2 ( p all < 0.05). GSH-px of plasma and lung tissues decreased in sepsis ( p for plasma <0.05) and increased in sepsis+SO2 ( p for GSH-px of lung tissues <0.05). TNF-α of plasma and lung tissues increased in sepsis ( p all<0.05) and decreased in sepsis+SO2 ( p for lung tissue <0.05). Conclusion. Endogenous sulfur dioxide improves the survival rate of sepsis by improving the oxidative stress response during lung injury.

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“…The use of genes related to product features to evaluate animal genotypes is a straightforward, in-demand, ad accessible strategy for predicting the productive attributes of beef cattle at an early age [1][2][3]. In recent years, beef cattle breeding in Russia has expanded significantly due to implementing the sectoral program "Development of beef cattle breeding in Russia for 2013-2020" [4][5][6]. During this period, the volume of beef cattle production increased 4.1 times and is 20% of the total domestic beef production.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

0

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The current study investigated the impact of growth hormone (GH) and polymorphism of calpain genes (CAPN1) on the changes in live weight and qualitative and quantitative indicators of meat productivity of young Kazakh White-headed cattle. CAPN1 polymorphism is represented by two alleles, C and G, with a frequency of 0.12 and 0.88, three genotypes, CC, CG, GG, with a frequency of 0.06, 0.81, and 0.13, respectively. GH polymorphism -V and L alleles, with a frequency of 0.40 and 0.60, and VV, LV, and LL genotypes with a frequency of 0.31, 0.51, and 0.18, respectively. The CAPN1 C and GH V alleles are preferred for improving the quantity and quality of meat productivity of the Kazakh white-headed cattle. Animals with the CAPN1 CC and GH VV genotypes had a 6.9% higher body weight at 12 months of age (P<0.05) compared to those with the CAPN1 GG and GH LL genotypes. The highest preslaughter, slaughter, and carcass weights were obtained from carcasses of CAPN1 CC and GH VV homozygous bulls. Their superiority over the CAPN1 GG and GH LL genotypes was 19.3; 16.2 and 16.4 kg; 19.8; 19.1 and 16.1 kg, respectively. The difference in favor of these genotypes in terms of the meat ratio by 4.1% and 2.0% was provided by a 9.1% greater meat mass and 1.4% and 2.0% slaughter yield. The protein and fat content in the longissimus muscle of the CC and VV genotypes carcasses was higher by 0.28-2.13%. CAPN1 CC and GH VV animals had a higher concentration of unsaturated fatty acids in their muscle lipids than CAPN1 CG , CAPN1 GG, and GH LV , GH LL genotypes. The best unsaturated to saturated fatty acids ratio and the ratio of arachidonic (C20:4) and linoleic (C18: 2) acids indicate the advantage in beef's dietary properties obtained from beef CAPN1 CC and GH VV animals.

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“…However, several groups have proposed that thyroid hormone reduces smooth muscle contractility by altering the interaction of myosin light chain kinase with calmodulin. [19][20][21] Unfortunately, the effects of thyrotoxicosis on this relationship remain uncertain, because the vasodilatory effect is obscured by an augmented vasoconstrictor response to norepinephrine in the hyperthyroid state. 22 More focused investigation is warranted.…”

Section: Thyroid Hormone and Lung Developmentmentioning

confidence: 99%

Neonatal Thyrotoxicosis and Persistent Pulmonary Hypertension Necessitating Extracorporeal Life Support

Oden

¹

,

Cheifetz

²

2005

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ABSTRACT. We report a case of neonatal Graves' disease involving an infant with severe persistent pulmonary hypertension (PPHN) associated with neonatal thyrotoxicosis that necessitated extracorporeal membrane oxygenation. Hyperthyroidism, although uncommon in the newborn period, has been associated with pulmonary hypertension among adults. The exact mechanisms responsible for this effect on pulmonary vascular pressure are not well understood. Recent studies have provided evidence that thyrotoxicosis has direct and indirect effects on pulmonary vascular maturation, metabolism of endogenous pulmonary vasodilators, oxygen economy, vascular smooth muscle reactivity, and surfactant production, all of which may contribute to the pathophysiologic development of PPHN. Therefore, because PPHN is a significant clinical entity among term newborns and the symptoms of hyperthyroidism may be confused initially with those of other underlying disorders associated with PPHN (eg, sepsis), it would be prudent to perform screening for hyperthyroidism among affected newborns. ABBREVIATIONS. PPHN, persistent pulmonary hypertension; PVR, pulmonary vascular resistance; ECMO, extracorporeal membrane oxygenation; NO, nitric oxide; NOS, nitric oxide synthase; TTF-1, thyroid transcription factor-1; ADMA, asymmetricH yperthyroidism, although uncommon in the newborn period, has been associated with pulmonary hypertension among adults. 1,2 The exact mechanisms responsible for this effect on pulmonary vascular pressure are not well understood. Persistent pulmonary hypertension (PPHN), a major cause of morbidity and death among term newborns, 3 is associated with perinatal asphyxia and perhaps chronic intrauterine hypoxia. Acute hypoxemia induces pulmonary vasoconstriction, whereas prolonged hypoxia causes hypertrophy of the smooth muscle layer of the small pulmonary arterioles, resulting in persistently elevated pulmonary vascular tone. 3 In either situation, increased pulmonary vascular resistance (PVR) causes a subsequent increase in right ventricular pressure, a patent foramen ovale, and a patent ductus arteriosis in the postnatal period. The resultant, potentially severe, right-to-left shunting is the hallmark of PPHN. Infants with severe PPHN may require extracorporeal membrane oxygenation (ECMO) for adequate oxygen delivery until the elevated PVR resolves.Although the pathophysiologic development of PPHN is multifactorial, certain conditions, such as congenital diaphragmatic hernia, cyanotic congenital heart disease, and sepsis, predispose infants to elevated PVR. These conditions are associated with hypoxia, acidosis, and elevated levels of proinflammatory cytokines. This environment promotes altered vasodilator synthesis and increased vasoconstriction through several poorly defined pathways. Interestingly, thyrotoxicosis is associated with similar clinical and biochemical findings.The association between hyperthyroidism and pulmonary hypertension is unclear. Thyroid hormone has dramatic and contrasting effects on the cardiovascular sy...

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Cyclic Adenosine 3′,5′‐monophosphate Content and Bronchial Smooth Muscle Contractility of Hyper‐ and Hypothyroid Lungs

Cited by 5 publications

References 15 publications

Endogenous Sulfur Dioxide Improves the Survival Rate of Sepsis by Improving the Oxidative Stress Response during Lung Injury

Endogenous Sulfur Dioxide Improves the Survival Rate of Sepsis by Improving the Oxidative Stress Response during Lung Injury

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Neonatal Thyrotoxicosis and Persistent Pulmonary Hypertension Necessitating Extracorporeal Life Support

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