Cyclic Amp And Psoriasis

Halprin, Kenneth M.; Adachi, Kenji; Yoshikawa, Kunihiko; Levine, Victor E.; Mui, Mei Mei; Hsia, S.L.

doi:10.1111/1523-1747.ep12598119

Cited by 36 publications

(11 citation statements)

References 26 publications

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“…We also agree with the recent conclusion of Marcelo et al (1979) and with the previous reports of Yoshikawa et al (1975b) and Halprin et al (1975) that cAMP levels in lesional skin do not differ significantly from those in non-involved skin. We could not, however, confirm the finding of the Michigan group that the cAMP content of all psoriatic epidermis is decreased compared to the normal epidermis.…”

supporting

confidence: 94%

The effect of steroid and dithranol therapy on cyclic nucleotides in psoriatic epidermis

Saihan

Albano

Burton

1980

British Journal of Dermatology

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Absolute values of both cAMP and cGMP leves were measured in the involved and uninvolved skin of psoriatic patients, and also the effect of topical therapy on these levels in the involved skin was studied. The mean cGMP level in the untreated psoriatic plaque was increased by 300% compared to the non-involved skin (which did not differ from normal skin), but no significant difference in cAMP levels was found. Epidermal stripping of uninvolved skin, which stimulates cell proliferation, did not change the cGMP level. Treatment of the psoriasis with dithranol caused the cGMP levels to return to normal, but a potent topical glucocorticoid, in contrast, produced no such decrease. This may imply that the two drugs act at different levels in suppressing cell replication, and dithranol may be a useful tool for the further investigation of cyclic nucleotide metabolism.

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supporting

confidence: 94%

The effect of steroid and dithranol therapy on cyclic nucleotides in psoriatic epidermis

Saihan

Albano

Burton

1980

British Journal of Dermatology

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“…Other works have exclusively dealt with cAMP [Harkônen et al, 1974;Halprin et al, 1975], However, considering the utilization of different methods for tissue preparation and cAMP assay, the results and their interpretation are inconsistent. In a more recent work, where the epidermal area is frozen in vivo by application of liquid nitrogen and the biopsies taken without anesthesia, Adachi et al [1980] found no difference in basal cAMP level between normal and uninvolved psoriatic tissue, and a mild increase of this compound in involved psoriatic epidermis.…”

Section: Discussionmentioning

confidence: 99%

Cyclic AMP and Cyclic GMP Production in Normal and Psoriatic Epidermis

Royer

Chaintreul²,

Meynadier

et al. 1982

Dermatology

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cAMP and cGMP production was determined in normal and psoriatic (involved or uninvolved) epidermis. After homogenization, epidermal strips were incubated with saturating concentrations of ATP or GTP, respectively, for cAMP and cGMP production. Cyclic nucleotides were measured by radioimmunoassay before and after 5, 10,20 min of incubation. The kinetics of cAMP and cGMP production were linear during the 20 min of incubation. Comparison of normal skin, uninvolved and involved psoriatic skin, prior to and after 20 min of incubation showed the following results: cAMP levels were significantly higher in normal skin than in psoriatic skin at zero time (p < 0.01) and after incubation (p < 0.05). cGMP levels were not significantly different in the three tissues at zero time. After incubation, psoriatic involved epidermis exhibited a higher production of cGMP than normal skin (p < 0.05). Thus, the ratio cAMP/cGMP was higher in normal skin than in psoriatic skin at the basic level (p < 0.05) and after incubation (p < 0.01). These results indicate an imbalance in cyclic nucleotides metabolism in psoriatic skin without a significant difference between uninvolved and involved epidermis.

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“…There are four stimulators linked to adenylatecyclase receptors in the plasma membrane of human (1)(2)(3)(4) and pig (5)(6)(7)(8) There are four stimulators linked to adenylatecyclase receptors in the plasma membrane of human (1)(2)(3)(4) and pig (5)(6)(7)(8) …”

Section: Introductionmentioning

confidence: 99%

Cyclic Amp‐dependent Protein Phosphorylation of Pig Epidermal Homogenates

Aoyagi

Umeda

Kato

et al. 1982

The Journal of Dermatology

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There are four independent stimulators (epinephrine, histamine, adenosine and prostaglandin E) of the adenylate cyclase receptor on the epidermal cell surface, all of which increase intracellular cyclic AMP. These stimulators and db‐cAMP inhibit epidermal cell proliferation and promote epidermal cell differentiation, although conflicting effects have been reported in pure epidermal cell culture systems. In order to elucidate the physiological roles of cyclic AMP in epidermal cells, endogenous protein phosphorylation of pig epidermal homogenates was studied. The autoradiographic analysis by SDS‐PAGE demonstrated that cyclic AMP (10 μM) stimulated the phosphorylation of several epidermal proteins. One group of these endogenous substrates were keratinous proteins. These phosphoproteins were dephosphorylated by chelating Mg2+ with EDTA. The addition of unlabeled ATP diminished the intensity of phosphoprotein bands. These results indicate that pig epidermal homogenates have cyclic AMP‐dependent protein kinase and that some endogenous substrates were keratinous proteins.

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Cyclic Amp And Psoriasis

Cited by 36 publications

References 26 publications

The effect of steroid and dithranol therapy on cyclic nucleotides in psoriatic epidermis

The effect of steroid and dithranol therapy on cyclic nucleotides in psoriatic epidermis

Cyclic AMP and Cyclic GMP Production in Normal and Psoriatic Epidermis

Cyclic Amp‐dependent Protein Phosphorylation of Pig Epidermal Homogenates

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