Cyclic AMP Phosphodiesterase Inhibitory Activity and Chemical Screening of Four Medicinal Plants

Abstract

Four medicinal plants, Acorus calamus Linn., Alpinia galanga Willd., Desmodium triquetrum D.C. and Vitis discolour Dalz., were investigated for potential to inhibit cyclic AMP phosphodiesterase. The alcohol extract of Desmodium triquetrum was found to be most active. The chloroform and alcohol extracts of Desmodium triquetrum and Acorus calamus, and the petroleum ether and chloroform extracts of Alpinia galanga contain flavonoids. These are possibly the active principles responsible for their anti-bacterial activity.

Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer’s disease

“…However extracts/bio-active compounds of theses plant (Alpinia galanga, Scutellaria baicalensis, and Forsythia suspensaand vitis vinifera) have been reported to produce neuroprotection against oxidant and inflammatory studies. Although, published data shows these plants are neuroprotective and have PDE inhibitory potential by restore cyclic nucleotide levelsin brain (Chit et al, 2001;Dell'Agli et al, 2005;Nikaido et al, 1989). Further mechanistic studies are required to investigate such types of mechanism.…”

“…The extracts of plants (Ginko biloba, Poly tenuifolia and Acorus calamus) has also been reported to increase the ACh level in brain and found to be neuroprotective against AChE induced memory deficit. Although in other studies, these plants are reported for their PDE inhibitory potential (Chit et al, 2001;Macovschi et al, 1987;Nikaido et al, 1981) but further study is needed for identification of neuroprotective mechanism, by restoring cyclic nucleotide levels in relation to Alzheimer's disease.…”

“…Although these plants (Ginkgo biloba, Poly tenuifolia and Nelumbo nucifera) shows neuroprotective effect in various disease models. In other studies these plants are reported for their PDE inhibitory potential and can restore cyclic nucleotide levels (Chen et al, 2008;Chit et al, 2001;Temkitthawon et al, 2008), but further mechanistic study is required to explore neuroprotective mechanism in relation to cognitive disorders.…”

“…Amyloid ␤ production could be reduced by inhibiting the ␤-secretase activity (on enzyme binding with ␥ secretase involved in the cleavage of APP to form A␤) or by enhancing ␣ secretase activity, (an enzyme involved in the cleavage of APP to form soluble proteins but not A␤) (Yan and Vassar, 2014). The extracts of these plants (Ginko biloba, Poly tenuifolia and Acorus calamus) has been reported to produce PDE inhibitory activity and can restore cyclic nucleotide levels (Chit et al, 2001;Macovschi et al, 1987;Nikaido et al, 1981). Although various other mechanism have been reported for their neuroprotective action against A␤ and Tau, however, PDE inhibition and restoration of cyclic nucleotide action could also be reported with their neuroprotective action and through verification of such mechanism are needed.…”

Anti-inflammatory and in vitro antioxidant activity of Desmodium triquetrum (L.)

“…[ 7 ] It has been reported that alcohol extract of D. triquetrum was found to inhibit cAMP-PDE activity. [ 8 ] Therefore, the possible mechanism for significant anti-inflammatory activity of DTE may be by inhibition of cAMP-PDE activity and also it can be attributed to its antioxidant activity as evidenced by the presence of flavonoids. Further, the isolation of the compounds responsible for the claimed activities has to be taken up to support the present findings.…”