Cyclic and non-cyclic breast-pain: A systematic review on pain reduction, side effects, and quality of life for various treatments

Groen, Jan-Willem; Grosfeld, S.; Bramer, Wichor M.; Ernst, Miranda F.; Mullender, Magriet M.

doi:10.1016/j.ejogrb.2017.10.018

Cited by 29 publications

(21 citation statements)

References 37 publications

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“…7 Cyclical pain can account for 70% of breast pain, noncyclical breast pain accounts for up to 25% of the cases of breast pain. 8 Such kind of discomfort seriously affected women's self-esteem and quality of life.…”

Section: Introductionmentioning

confidence: 99%

Chinese herbal medicine (Rupi Sanjie capsule) for the treatment of breast pain: A systematic review and meta-analysis of randomized clinical trials

Lai

Jia

et al. 2021

Integrative Medicine Research

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Background Breast pain is one of the most common breast disorders, affecting 41%–69% women in the clinical populations. Chinese herbal medicine (Rupi Sanjie, RPSJ) capsule has been recommended to be commonly used for breast pain in China. This review aimed to systematically collect latest evidence and critically evaluate the eﬀ ;ectiveness and safety of RPSJ capsule for breast pain. Methods We searched 6 databases from their inception to June 1, 2020 for randomized clinical trials (RCTs) comparing RPSJ capsule with conventional drug therapies, placebo or no treatment. Primary outcomes were breast pain relief, reduction of breast mass and clinical cure rate. Results Seventeen RCTs were included in total, involving 2899 participants with breast pain. RPSJ capsule showed a significant effects in shortening duration of the breast pain (MD-6.51 days, 95%CI [-8.57, -4.45], n = 82, 1 trial), shortening the duration of breast mass (MD-5.17 days, 95%CI [-7.56, -2.78], n = 82, 1 trial), improving clinical cure rate (RR 1.55, 95% CI [1.21, 2.00], I² = 64%, n = 1398, 10 trials) and total effective rate (RR 1.08, 95% CI [1.03, 1.14], I² = 71%, n = 2170, 14 trials) compared to Tamoxifen (TAM). The meta-analysis showed that the incidence of total adverse events was higher in TAM group than the RPSJ capsule group (RR 0.30, 95%CI [0.21, 0.42], I² = 49%, n = 2122, 13 trials). Conclusions RPSJ capsule appears to be a potentially effective in treating breast pain and seems generally safe for clinical application. However, this potential benefit is inconclusive due to generally weak evidence, and the findings should be further confirmed in large and rigorous trials.

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Section: Introductionmentioning

confidence: 99%

Chinese herbal medicine (Rupi Sanjie capsule) for the treatment of breast pain: A systematic review and meta-analysis of randomized clinical trials

Lai

Jia

et al. 2021

Integrative Medicine Research

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“…The pain is mostly described by the patients as sharp, burning, constant, and usually unilateral, radiating to the ipsilateral shoulder. Several other factors have also been investigated in terms of their causal relationship with NCBP, including breast size, smoking habits, cysts, periductal mastitis, stretching of Cooper’s ligaments, traumatic fat necrosis, and diabetic mastopathy; nevertheless, the majority of patients do not present with any of these features [ 7 ]. Although found in a small proportion of affected women, irregular menstrual cycles, oral contraceptives, hormonotherapies, psychosomatic factors, emotional distress, and some drugs (cardiovascular agents, psychotropic drugs, etc.)…”

Section: Introductionmentioning

confidence: 99%

“…Although found in a small proportion of affected women, irregular menstrual cycles, oral contraceptives, hormonotherapies, psychosomatic factors, emotional distress, and some drugs (cardiovascular agents, psychotropic drugs, etc.) are considered to be related to NCBP [ 1 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…The most common extra-mammary pain syndromes are chest wall pain caused by costochondritis and radicular pain due to arthritis, fibromyalgia, and other musculoskeletal pathologies. Cardiovascular, hepatobiliary, and neurological pathologies are uncommon causes of BP but they should still be taken into consideration because of their high morbidity rates [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Sleep disturbances and non-cyclical breast pain: where to break the vicious cycle?

Basım

Tolu

2021

Sleep Breath

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Purpose This study aimed to assess the sleep quality of patients with the complaint of non-cyclical breast pain (NCBP), compare them to a healthy control group, and analyze the interrelationship of sleep quality with pain, anxiety, depression, and quality of life. Methods This cross-sectional study was conducted in consecutive women presenting to the general surgery clinic between May 2020 and December 2020. Patients diagnosed with NCBP formed one group for study and 44 receiving routine wellwoman care formed the control group. Evaluations were undertaken using the Nottingham Health Profile (NHP), short-form McGill Pain Questionnaire (SF-MPQ), Hospital Anxiety and Depression Scale (HADS), and Pittsburgh Sleep Quality Index (PSQI).Results Of 160 consecutive patients, 116 were diagnosed with NCBP and 44 controls. Poor sleep quality (PSQI > 5) was present in 59% (n = 69) of the women with NCBP and 38% (n = 17) of the controls (p = 0.018). According to PSQI global score, overall sleep quality was significantly lower in the NCBP group compared to the control group (p < 0.007). Sleep latency, sleep duration, and daytime dysfunction were the major components determining the PSQI global score (p = 0.004, p = 0.004, and p < 0.001, respectively). The correlation matrix revealed a statistically significant correlation between the HAD-A, HAD-D, and SF-MSQ and NHP subgroups and PSQI global score in the NCBP group (p < 0.001) whereas this significant correlation was detected with only the NHP subgroups among the controls. Conclusions A considerable proportion of NCBP patients, regardless of sensory or affective characteristics and trajectory of pain, experience significant sleep disturbances. Further studies should be conducted to evaluate the existence of central sensitization syndrome in NCBP patients to determine the required pharmacological treatment.

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“…It is common in 40–50 years of age in women (3) Extra-mammary pain/chest wall pain—musculoskeletal pain is always associated with unilateral of breast. [ 3 4 5 6 7 ] CM is generally nonthreatening but anxiety to undergo with breast cancer is approach to consultation and it's a benign breast disease. [ 8 ] Although mastalgia is common, the impact on everyday living should not be underestimated.…”

Section: Introductionmentioning

confidence: 99%

An alternative yogic approach for cyclical mastalgia—A narrative review

Jaiswal

Thakur

2021

Journal of Family Medicine and Primary Care

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Background: Mastalgia or breast pain common benign breast disorder in women in her reproductive life. Mastalgia estimate prevalence 41–71%. It affects to overall quality of life and associated with anxiety, stress, and other psychological factors. Objective: The purpose of the study was to conduct a review of alternative therapy in the management of mastalgia. Method: A review was conducted using search terms cyclical mastalgia (CM), yoga therapy, breast treatment, primrose oil, oestrogen, progesterone and all the probable term in national and international data repositories such as PubMed, Scopus, science direct, google scholar, web of science in English language. Result: The review of alternative therapies in the management of CM suggests that most of the studies used primrose oil, vitamins, and physical activity. There are very few studies conducted in relation to yoga and cyclical mastalgia. Further, most of the studies explored effect of alternative therapies on psychological outcomes. None of the studies investigated efficacy of these therapies on hormonal changes. Conclusion: Evidence suggests that biochemical clinical trial is effective with side effect, primrose oil and seeds treatment is less effective. One evidence-based study with integrated yoga therapy should be considered in the management of cyclical mastalgia. More high-quality trial with yogic approach needed to first line management of patients presenting with CM.

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Cyclic and non-cyclic breast-pain: A systematic review on pain reduction, side effects, and quality of life for various treatments

Cited by 29 publications

References 37 publications

Chinese herbal medicine (Rupi Sanjie capsule) for the treatment of breast pain: A systematic review and meta-analysis of randomized clinical trials

Chinese herbal medicine (Rupi Sanjie capsule) for the treatment of breast pain: A systematic review and meta-analysis of randomized clinical trials

Sleep disturbances and non-cyclical breast pain: where to break the vicious cycle?

An alternative yogic approach for cyclical mastalgia—A narrative review

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