Cyclic change of cytokines in a patient with cyclic thrombocytopenia

Kimura, Fumihiko; Nakamura, Yukistugu; Sato, Ken; Wakimoto, Naoki; Kato, Takashi; Tahara, Tomoyuki; Yamada, Muneo; Nagata, Naokazu; Motoyoshi, Kazuo

doi:10.1046/j.1365-2141.1996.d01-1783.x

Cited by 37 publications

(39 citation statements)

References 9 publications

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“…A preliminary report13 of gene expression profile of two male patients with CT published in abstract form noted cyclic changes in interferon responsive genes as well as transcription factors controlling lineage differentiation. Cytokine oscillations have also been documented in periodic hematological diseases, including CT 10, 14, 15, 16…”

Section: Discussionmentioning

confidence: 99%

Cyclic thrombocytopenia with statistically significant neutrophil oscillations

Langlois

Arnold

Potts

et al. 2018

Clinical Case Reports

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Key Clinical MessageCyclic thrombocytopenia is often misdiagnosed as immune thrombocytopenia due to similar clinical features, a fact of significance because cyclic thrombocytopenia generally responds poorly to treatments used successfully in immune thrombocytopenia. A precise diagnosis must establish the statistical significance of periodicity of the platelet counts using statistical methods (eg, Lomb‐Scargle periodogram).

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Section: Discussionmentioning

confidence: 99%

Cyclic thrombocytopenia with statistically significant neutrophil oscillations

Langlois

Arnold

Potts

et al. 2018

Clinical Case Reports

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“…16 Also in human studies, TPO levels changed reciprocally to platelet counts in patients with cyclic thrombocytopenia or undergoing bone marrow transplantation after myeloablative therapy. [21][22][23][24] On the other hand, it was described that TPO levels were high when thrombocytopenia was due to megakaryocyte deficiency, and low when due to increased platelet destruction, 19 and that serum megakaryocyte colony-stimulating activity levels appeared to be inversely related to marrow megakaryocyte numbers. 25 In the present study, we could clearly demonstrate using a sensitive ELISA that human TPO levels also changed inversely with the number of platelets after myelosuppressive chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Serum thrombopoietin levels in patients correlate inversely with platelet counts during chemotherapy-induced thrombocytopenia

et al. 1998

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We studied serum thrombopoietin (TPO) levels and circulating numbers of platelet during five courses of myelosuppressive post-remission chemotherapy in three patients with acute leukemia in complete remission. Serum TPO levels were measured by a newly developed and sensitive sandwich enzyme-linked immunosorbent assay. In all courses, serum TPO levels changed reciprocally with the platelet counts. When platelets were transfused into patients near the time of platelet nadir, the TPO levels dropped temporarily, while platelet counts temporarily increased. In addition, platelets obtained after transfusion in a thrombocytopenic patient showed lower binding to biotinylated TPO than donor platelets prior to the transfusion. The finding indicated that the TPO receptors were saturated with endogenous TPO of the patient with a high serum TPO level. These results suggest that the platelet mass directly regulates serum TPO levels by receptor-mediated absorption and is one of the major regulators of serum TPO levels in humans.

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“…The pathophysiologic mechanisms producing cyclic thrombocytopenia remain elusive. Potential biologic correlates, autoantibody production [2,3], cytokine levels [4], and fluctuating megakaryocyte mass [5] appear to be heterogeneous among patients and have not been widely studied. We describe a patient with cyclic thrombocytopenia with a persistent proliferation of large granular lymphocytes (LGLs).…”

Section: Introductionmentioning

confidence: 99%

Large granular lymphocytic proliferation-associated cyclic thrombocytopenia

et al. 2005

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Cyclic thrombocytopenia is a rare condition characterized by regular fluctuations in the platelet count, resulting in bleeding at the time of platelet count nadir. We evaluated a male patient whose platelet count cycled between <10 · 10 9 /L and a maximum of >1300 · 10 9 /L over a median of every 42 days (range, 28-57 days). Antiplatelet antibodies were present at highest titer just prior to platelet nadirs. A pathologic expansion of CD3 + CD57 + large granular lymphocytes (LGLs) along with a clonal rearrangement of the T-cell receptor (TCR) gamma gene in circulating T cells was detected.LGLs decreased in response to treatment with cyclosporine-A (CsA), but the cycling of the platelet count continued. This is the first report of cyclic thrombocytopenia associated with a T-LGL lymphoproliferative disorder. Am.

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Cyclic change of cytokines in a patient with cyclic thrombocytopenia

Cited by 37 publications

References 9 publications

Cyclic thrombocytopenia with statistically significant neutrophil oscillations

Cyclic thrombocytopenia with statistically significant neutrophil oscillations

Serum thrombopoietin levels in patients correlate inversely with platelet counts during chemotherapy-induced thrombocytopenia

Large granular lymphocytic proliferation-associated cyclic thrombocytopenia

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