Cyclic Changes in the Metabolism of Glycogen in Cervical Mucus of Bonnet Monkeys (Macaca Radiata)

Sheth, A. R.; Shah, Girish V.; Gadgil, B. A.; Rao, Shanta S.

doi:10.1530/jrf.0.0420133

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Thus the two catabolic enzymes measured had different patterns during the oestrous cycle with total glycogen phosphorylase showing a rise from day 1 to day 8, whereas IX-amylase showed maximum activity at day O. Similarly a difference in pattern between glycogen phosphorylase and IX-amylase during the menstrual cycle has been reported in the cervical mucus of the Bonnet monkey (Sheth et al 1975).…”

Section: Discussionmentioning

confidence: 59%

Activity of Enzymes in the Mucosal Tissues and Rinsings of the Reproductive Tract of the Naturally Cyclic Ewe

Murdoch¹,

O’Shea²

1978

Aust. Jnl. Of Bio. Sci.

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The activity of several enzymes has been measured in the oviducal mucosa, endometrium, caruncles, cervical mucosa and vaginal mucosa as well as in uterine, cervical and oviducal rinsings of ewes at days 0 (oestrus), 1, 8 and 15 of the oestrous cycle.Acid phosphatase activity was maximal during the luteal phase in the oviduct, endometrium and cervix, but not in the vagina where the highest level was on day 1. Alkaline phosphatase activity showed a significant rise at mid-cycle in the endometrium and caruncles as did glucose-6-phosphate dehydrogenase activity in the endometrium.Glycogen (starch) synthase in the endometrium and cervical mucosa was greater at days 0 and 8 than at days 1 and 15. Vaginal and caruncular total glycogen (starch) synthase activity showed a significant rise at mid-cycle. Active and total glycogen phosphorylase activities were maximal on days 8 and 15 in the vagina. Glycogen concentration was greatest at days 8 and 15 in the cervix, while oviduct values were lower on day 1 than at oestrus or day 15.In the oviduct rinsings alkaline phosphatase activity was greatest at day 1, whereas in cervical rinsings the activities of acid and alkaline phosphatases were less at oestrus than at days 8 and 15. The glycogen phosphorylase and p-glucuronidase activities in uterine rinsings were greater at days 8 and 15 than at oestrus.

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Section: Discussionmentioning

confidence: 59%

Activity of Enzymes in the Mucosal Tissues and Rinsings of the Reproductive Tract of the Naturally Cyclic Ewe

Murdoch¹,

O’Shea²

1978

Aust. Jnl. Of Bio. Sci.

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Morphologic and Immunohistochemical Features of the Cynomolgus Macaque Cervix

Wood

2008

Toxicol Pathol

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Female macaques serve as an important model for the study of reproductive diseases in women. Here we summarize characteristics of the macaque cervix, with a particular emphasis on the cynomolgus macaque. Key anatomic features include a stratified squamous exocervix, squamocolumnar junction and transformation zone, and glandular endocervix with prominent colliculi. Endocervical eversion occurs with onset of ovarian cycling and regresses to varying degrees based on age, hormonal status, and individual conformation. The cervical epithelium in macaques is highly responsive to estrogens, which induce marked squamous epithelial maturation and glandular hypertrophy. Progestogen effects include further induction of endocervical secretory activity and release of viscous mucus, which functions in both mucosal immunity and fertility regulation. On immunohistochemistry, the squamous cervix shows strong expression of estrogen receptor α, the proliferation marker Ki67/MIB1, and cytokeratin 14, whereas endocervical epithelium strongly expresses estrogen and progesterone receptors and cytokeratins 18 and 19. These patterns of expression are altered in cervical intraepithelial neoplasia, which is a common spontaneous lesion of the macaque cervix associated with specific types of oncogenic papillomaviruses. This report highlights important similarities with human cervix that should be useful for future studies of genital infection, neoplasia, and immunity in the macaque model.Competing Interests: This article was sponsored by Covance Inc. and Schering-Plough. The author did not declare any other competing interests.

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Cyclic Changes in the Metabolism of Glycogen in Cervical Mucus of Bonnet Monkeys (Macaca Radiata)

Abstract: The bonnet monkey (Macaca radiata) of

Cited by 2 publications

References 11 publications

Activity of Enzymes in the Mucosal Tissues and Rinsings of the Reproductive Tract of the Naturally Cyclic Ewe

Activity of Enzymes in the Mucosal Tissues and Rinsings of the Reproductive Tract of the Naturally Cyclic Ewe

Morphologic and Immunohistochemical Features of the Cynomolgus Macaque Cervix

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