Cyclic changes of blood echogenicity in high-frequency ultrasound

Kroon, M.G.M. de; Slager, C. J.; Gussenhoven, W. J.; Serruys, P.W.; Roelandt, Jos R.T.C.; Bom, N.

doi:10.1016/0301-5629(91)90105-6

Cited by 78 publications

(9 citation statements)

References 21 publications

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“…Cyclic variations in this study were small when compared with previous results obtained with whole porcine blood at 10 MHz (Cloutier and Shung 1993;Wu and Shung 1996;Lin and Shung 1999;Paeng et al 2001), whereas they cannot quantitatively be compared with De Kroon et al (1991). First, in the current paper the pulsatile flow was investigated in a Couette system instead of a mock tube flow loop or in-vivo conditions.…”

Section: Comparison With Previous Studies On Cyclic Echogenicity Varimentioning

confidence: 74%

“…De Kroon et al (1991) were the first to report in-vivo cyclic variations of blood echogenicity by using a 30-MHz intravascular ultrasound device. The catheter was placed in the iliac artery of patients with coronary artery disease and cyclic changes in blood echo-density were measured.…”

Section: Previous Results On Blood Echogenicity Under Pulsatile Flowmentioning

confidence: 99%

“…Thus, our hypothesis is that high-frequency transducers might have an improved detection to small RBC aggregate size variations at high stroke rates and could outperform low-frequency transducers for this application. Another hypothesis that might explain differences between in-vivo and in-vitro results is that blood from patients with coronary artery disease, as studied by De Kroon et al (1991), is likely more prone to be hyperaggregating than porcine blood. Consequently, RBC aggregation and disaggregation at high stroke rates might occur with pathologic blood because of the higher aggregation kinetics and larger size of RBC clusters.…”

Section: Previous Results On Blood Echogenicity Under Pulsatile Flowmentioning

confidence: 99%

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Cyclic Changes in Blood Echogenicity Under Pulsatile Flow Are Frequency Dependent

Nguyen¹,

Yu²,

Cloutier³

2008

Ultrasound in Medicine & Biology

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Section: Comparison With Previous Studies On Cyclic Echogenicity Varimentioning

confidence: 74%

Section: Previous Results On Blood Echogenicity Under Pulsatile Flowmentioning

confidence: 99%

Section: Previous Results On Blood Echogenicity Under Pulsatile Flowmentioning

confidence: 99%

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Cyclic Changes in Blood Echogenicity Under Pulsatile Flow Are Frequency Dependent

Nguyen¹,

Yu²,

Cloutier³

2008

Ultrasound in Medicine & Biology

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“…The weak scattering of ultrasound from soft tissues has the potential to provide in vivo information on reversible red blood cell aggregation induced by plasma proteins [15]. Recent observations indeed indicate that red blood cell aggregation results in significant variations of the ultrasonic backscattered power across the vessel lumen [16,17]. Much of contributions have been directed at understanding the relationship between the ultrasonic scattered power and particle volume fraction for different flow conditions [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound and light scattering from a suspension of reversible fractal clusters in shear flow

Snabre

Haider²,

Boynard³

2000

The European Physical Journal E - Soft Matter

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Shear break-up of reversible fractal clusters is investigated by ultrasound and multiple light scattering in the low shear regime. We consider a dense suspension of Rayleigh scatterers (particles or clusters) with acoustic properties close to those of the surrounding liquid so that the attenuation of the ultrasonic coherent field is weak and multiple scattering is negligible. The concept of variance in local particle volume fraction is used to derive an original expression of the ultrasound scattering cross-section per unit volume for Rayleigh fractal clusters. On the basis of a scaling law for the shear break-up of aggregates, then we derive the shear stress dependence of the ultrasound scattered intensity from a suspension of reversible fractal clusters. In a second part, we present rheo-acoustical experiments to study the shear breakup of hardened red cell aggregates in plane-plane flow geometry and we examine both the self consistent field approximation and the scaling laws used in microrheological models. We further compare the ability of acoustical backscattering and optical reflectometry techniques to estimate the critical disaggregation shear stress and the particle surface adhesive energy. Finally, the microrheological model from Snabre and Mills [5] based on a fractal approach is shown to describe the non Newtonian behavior of a dense distribution of hardened red cell aggregates. PACS. 42.25.Fx Diffraction and scattering -43.35.+d Ultrasonics, quantum acoustics, and physical effects of sound -43.80.+p Bioacoustics Nomenclature ν frequency (Hz), λ wavelength (m), a particle radius (m), R cluster radius (m), R maximum size of filling space subclusters at rest (m), δz axial resolution of the transducer (m), h gap width between rotating plates (m), z distance between the transducer and the insonified region (m), V particle volume (m 3 ), V a cluster volume (m 3 ), Ω volume of an elemental voxel (m 3 ), n particle number per unit volume (m −3 ), n a cluster number per unit volume (m −3 ), k, s incident and scattered wave number (m −1 ), q scattering wave number (q = s − k) (m −1 ), B cross-sectional area of the ultrasound beam (m 2 ), A c contact area between two particles (m 2 ), A particle area (m 2 ), a e-mail: snabre@imp-odeillo.fr b UPR 8521 du CNRS c phase velocity of the ultrasound wave (m/s), δtpulsewidth (s), ω particle number in a voxel, N particle number in a cluster, N b number of subunits of size 1/q in a cluster, D fractal dimension of a cluster, φ particle volume fraction, φ a cluster volume fraction, φ * maximum packing volume fraction, φ g gelation or percolation threshold, m critical exponent for cluster breakup, γ shear rate (s −1 ), τ shear stress (N/m 2 ), τ c critical disaggregation shear stress (N/m 2 ), τ * critical shear stress for cluster breakup (N/m 2 ), τ o yield stress (N/m 2 ), µ, µ a shear viscosity of the suspension (Ns/m 2 ), µ o shear viscosity of the suspending fluid (Ns/m 2 ), µ r relative shear viscosity of the suspension (µ r = µ a /µ o ), σ, σ α differential scattering...

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“…In addition, the normalized power spectrum of HFUS at 40 MHz has been applied to estimate the size of the aggregates [8]. The cyclic variation in blood echogenicity (CVBE) was first observed in the iliac artery using intravascular ultrasound imaging at 30 MHz [9], and was later measured to be dependent on frequency from in vitro experiments [2]. Recently, the cyclic variation of HFUS backscattering from blood has been observed under in vitro pulsatile flow [10][11][12].…”

mentioning

confidence: 99%

Feasibility Study of High-Frequency Ultrasonic Blood Imaging in Human Radial Artery

et al. 2015

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The present study investigates cyclic variation in blood echogenicity (CVBE) in vivo using high-frequency ultrasound (HFUS). Blood echogenicity (BE) and vessel diameter (VD) were obtained from cross-sectional B-mode images of the radial artery of six volunteers (three young and three old volunteers) acquired at a frequency of 20 MHz. The magnitudes of the cyclic variations in BE and VD were 0.83 ± 0.18 dB and 0.29 ± 0.05 mm, respectively. CVBE was observed to be out of phase with the cyclic variation in VD, which is known to be in phase with blood flow velocity. This result is different from those in previous studies, which were performed in the carotid artery at lower frequencies. In addition, the magnitude of CVBE in the older group (0.96 ± 0.05 dB) was higher than that in the younger group (0.63 ± 0.06 dB, p \ 0.005), whereas the magnitude of variation in VD was not significantly different between the two groups (p = 0.119). This feasibility study suggests that HFUS B-mode blood imaging of human small vessels is useful for the noninvasive measurement or monitoring of the dynamic variation of hemorheological properties in human blood.

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Cyclic changes of blood echogenicity in high-frequency ultrasound

Cited by 78 publications

References 21 publications

Cyclic Changes in Blood Echogenicity Under Pulsatile Flow Are Frequency Dependent

Cyclic Changes in Blood Echogenicity Under Pulsatile Flow Are Frequency Dependent

Ultrasound and light scattering from a suspension of reversible fractal clusters in shear flow

Feasibility Study of High-Frequency Ultrasonic Blood Imaging in Human Radial Artery

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