Cyclic compression loading on three-dimensional tissue of human articular chondrocytes upregulates inflammatory mediators and pain-sensitizing molecules
Abstract:Purpose: Thermal radiofrequency ablation (RF) is a minimally invasive procedure used to denervate the pain-transmitting peripheral nerves in chronic pain patients. Standard RF (SRF) and cooled RF (CRF) are two commonly used thermal ablation technologies hypothesized to provide pain relief by temporarily blocking signaling of the pain-transmitting sensory nerves and eliminating perception of pain in the central nervous system (CNS). CRF overcomes the lesion size limitations inherent to SRF administered at 80 C … Show more
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