At present, Kuzbass coal strip mines pay great attention to improving quality performance of mining equipment operation, including reliability and durability of components and units. One of the ways of the performance improvement is decreasing number of unforeseen failures. To achieve this purpose a mine dump truck part diagnostics should be introduced into a maintenance service procedure. At the same time the process of diagnostics should not increase the machinery downtime, but effectively reveal a condition of motor-wheel gearboxes in the course of dump truck operation. The aim of the research is to increase the reliability and service life of motor-wheel gearboxes of large BelAZ dump trucks. Failure of a motor-wheel gearbox is a rare phenomenon, but the cost of a new gearbox can vary from 3.5 to 10 million rubles. That is why it is important to implement such methods of diagnostics, which allow revealing the condition of gearboxes in the shortest possible time and without disassembling corresponding units. Determination of the actual technical condition of motor-wheel gearboxes is possible by different methods: vibroacoustic; acoustic; thermal; physical and chemical analysis of spent operating materials. The studies showed that none of these methods can be used as a universal one. When justifying and selecting the most suitable method, different factors should be considered, including technological, or a combination of methods should be applied, which will reduce risks, but at the same time increase costs. It is necessary to develop a better diagnostic method based on the use of several methods simultaneously.