Cyclic hydrazides

pH‐Sensitive Drug‐Conjugates on Water‐Soluble Polymer Frameworks

“…It has been also reported that the broad chemical shifts near δ = 9.0 ppm correspond to the protons on the nitrogen atom of the acyl HZ group (–C(O)–N H – or –C(O)–N H –N H 2 ) . Furthermore, it has been reported that the chemical shifts at δ = 7.15 ppm and 3.92 ppm can be separately assigned to the protons on the nitrogen atoms of the HZ group on the aliphatic chain (–C(O)–N H –NH 2 and (–C(O)–NH–N H 2 ) . Even considering all these disputable chemical shift assignments, it was difficult to match those of the intermediates to the analytical assignments.…”

“…[36][37][38][39] Furthermore, it has been reported that the chemical shifts at δ = 7.15 ppm and 3.92 ppm can be separately assigned to the protons on the nitrogen atoms of the HZ group on the aliphatic chain (-C(O)-N H -NH 2 and (-C(O)-NH-N H 2 ). [ 40 ] Even considering all these disputable chemical shift assignments, it was diffi cult to match those of the intermediates to the analytical assignments. As shown in Figure 3 b and 3 c, hydrazinolysis of PEO-b -P N -PMI in this study apparently delivered different types of chemical shifts depending on the conditions; this was in the range over δ = 6.5 ppm and corresponded to the HZ architectures shown in Table 1 .…”

Regioselective Cyanation of Six‐Membered N‐Heteroaromatic Compounds Under Metal‐, Activator‐, Base‐ and Solvent‐Free Conditions

“…The compound effectively underwent onepot oxidation and cyanation, yielding compound 2 s. 2 s represents an important reaction intermediate for MRK-8-29, [35] a specific in vivo agent for mGlu2 negative allosteric modulator. We discovered that several neuroactive agents can easily be accessed by simple hydrolysis of 2 l, leading to acridinic acid (11) [38] and it's derivative 2,3-dihydropyridazino [4,5-b] quinoline-1,4-dione (12) [39] in 72% and 71% yield, respectively (Scheme 3e). [36] Our protocol was also extended to the synthesis of the TB inhibitor 8 [11] and plant fungicide precursor 9 [37] , obtaining both in high yields (Scheme 3c and 3d).…”

“…Our protocol was also extended to the synthesis of the TB inhibitor 8 and plant fungicide precursor 9 , obtaining both in high yields (Scheme c and 3d). We discovered that several neuroactive agents can easily be accessed by simple hydrolysis of 2 l , leading to acridinic acid ( 11 ) and it′s derivative 2,3‐dihydropyridazino [4,5‐ b ] quinoline‐1,4‐dione ( 12 ) in 72% and 71% yield, respectively (Scheme e).…”