Cyclic kinetics and mathematical expression of the primary immune response to soluble antigen

Abstract

A mathematical expression of the accumulation of the plasma cells in the spleen of CBA mice immunized intraperitoneally is presented. The dependence of the plasma cell reaction in the spleen on the kinetics of antigen concentration in the blood was confirmed. For the transition from antigen to plasma cells, index A was proposed. The mean values of index A were used for comparison of the calculated and experimental values of the plasma cell reaction and the recorded differences were not great. In a similar way, index A was used for prediction of plasma cell accumulation in the spleen of animals, immunized with a mixture of two soluble antigens -- capsular antigen of Pasteurella pestis and complete antigen of Francisella tularensis. The calculated values of plasma cell reaction corresponded to experimental values.