2017
DOI: 10.1007/978-3-319-54579-0_6
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Cyclic Nucleotide Phosphodiesterases and Compartmentation in Normal and Diseased Heart

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Cited by 3 publications
(3 citation statements)
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References 124 publications
(136 reference statements)
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“…PDE family–selective inhibitors are available and have contributed significantly to our understanding of the role of different PDEs in the compartmentalization of cAMP ( Houslay et al, 2005 ; Lugnier, 2006 ; Francis et al, 2011b ; Page and Spina, 2012 ; Kokkonen and Kass, 2017 ). For example, in rat cardiac myocytes, PDE3 and PDE4 enzymes show a very distinct localization, and inhibition of PDE4, but not inhibition of PDE3, results in significant increase in cAMP levels generated by β -agonists ( Mongillo et al, 2004 ; Bedioune et al, 2017 ; Conti, 2017 ). Currently available pharmacological inhibitors do not discriminate between different isoforms within the same PDE family.…”
Section: Contribution To Compartmentalization Of Individual Pathmentioning
confidence: 99%
“…PDE family–selective inhibitors are available and have contributed significantly to our understanding of the role of different PDEs in the compartmentalization of cAMP ( Houslay et al, 2005 ; Lugnier, 2006 ; Francis et al, 2011b ; Page and Spina, 2012 ; Kokkonen and Kass, 2017 ). For example, in rat cardiac myocytes, PDE3 and PDE4 enzymes show a very distinct localization, and inhibition of PDE4, but not inhibition of PDE3, results in significant increase in cAMP levels generated by β -agonists ( Mongillo et al, 2004 ; Bedioune et al, 2017 ; Conti, 2017 ). Currently available pharmacological inhibitors do not discriminate between different isoforms within the same PDE family.…”
Section: Contribution To Compartmentalization Of Individual Pathmentioning
confidence: 99%
“…However, controversy exists regarding the diffusibility of cAMP in situations of physiological relevance. PDE's can conduct cAMP by setting up directional concentration gradients by forming sinks [32]. As well as the processes of calcium transport into the cell, the Na+/Ca 2+ -exchanger can extrude calcium from the interior of the cardiomyocyte to restore normal calcium concentrations [33].…”
Section: Active Mechanismsmentioning
confidence: 99%
“…Cyclic nucleotide degrading phosphodiesterases (PDEs) are a superfamily of hydrolyzing enzymes that play an important role in the regulation of dynamic cyclic nucleotide microdomains [ 13 ]. Myocardial predominant PDE3 and PDE4 have been more comprehensively studied.…”
Section: Introductionmentioning
confidence: 99%