2023
DOI: 10.1111/mmi.15119
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Cyclic di‐GMP signaling—Where did you come from and where will you go?

Abstract: Microbes including bacteria are required to respond to their often continuously changing ecological niches in order to survive. While many signaling molecules are produced as seemingly circumstantial byproducts of common biochemical reactions, there are a few second messenger signaling systems such as the ubiquitous cyclic di‐GMP second messenger system that arise through the synthesis of dedicated multidomain enzymes triggered by multiple diverse external and internal signals. Being one of the most numerous a… Show more

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Cited by 10 publications
(4 citation statements)
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“…This juxtaposition of genes involved in natural competence and translation arrest is broadly conserved, even among distantly related bacteria that lack the raiA motif RNA, and is consistent with competence as a developmental program that is often concomitant with growth arrest or a decrease in rRNA production ( 57 , 58 ). Given the importance of cyclic dinucleotide signaling to bacterial physiological changes ( 59 61 ), and given that these signaling molecules likely emerged during the RNA World ( 62 , 63 ), an intriguing possibility is that raiA motif RNAs serve as receptors or as ribozymes involved in cyclic dinucleotide signaling processes.…”
Section: Resultsmentioning
confidence: 99%
“…This juxtaposition of genes involved in natural competence and translation arrest is broadly conserved, even among distantly related bacteria that lack the raiA motif RNA, and is consistent with competence as a developmental program that is often concomitant with growth arrest or a decrease in rRNA production ( 57 , 58 ). Given the importance of cyclic dinucleotide signaling to bacterial physiological changes ( 59 61 ), and given that these signaling molecules likely emerged during the RNA World ( 62 , 63 ), an intriguing possibility is that raiA motif RNAs serve as receptors or as ribozymes involved in cyclic dinucleotide signaling processes.…”
Section: Resultsmentioning
confidence: 99%
“…The transition between planktonic and sessile existence involves changes in gene expression and metabolism of bacterial cells, associated with variations in the intracellular levels of the second messenger cyclic diguanylate (c-di-GMP) [4,5]. These, in turn, are modulated in response to chemical environmental and metabolic cues, as well as physical stimuli [6][7][8]. Among the molecules that influence c-di-GMP signalling and biofilm development, a noteworthy role has been ascribed to certain amino acids.…”
Section: Introductionmentioning
confidence: 99%
“…Recent research efforts have focused on targeting regulatory pathways, with the intracellular second messenger c-di-GMP emerging as a promising drug target ( Caly et al, 2015 ; Andersen et al, 2021 ). C-di-GMP serves as a signaling molecule present in virtually all bacteria, regulating crucial processes including antibiotic resistance, biofilm formation, and virulence ( Römling, 2023 ).…”
Section: Introductionmentioning
confidence: 99%
“…Targeting the c-di-GMP signaling pathway in P. aeruginosa offers a promising strategy to combat antibiotic-resistant infections ( Caly et al, 2015 ; An and Ryan, 2016 ; Andersen et al, 2021 ). By manipulating c-di-GMP levels, it is possible to influence key virulence traits of the bacterium, including biofilm formation and the production of virulence factors ( Bjarnsholt et al, 2010 ; Andersen et al, 2021 ; Mamat et al, 2023 ; Römling, 2023 ). This approach provides a unique opportunity to attenuate the pathogenicity of P. aeruginosa without exerting selective pressure for the development of antibiotic resistance.…”
Section: Introductionmentioning
confidence: 99%