Cyclic tensile strain-induced yes-associated protein activity modulates the response of human periodontal ligament mesenchymal stromal cells to tumor necrosis factor-α

Zhao, Zhongqi; Behm, Christian; Tian, Zhiwei; Rausch, Marco Aoqi; Rausch‐Fan, Xiaohui; Andrukhov, Oleh

doi:10.1016/j.archoralbio.2022.105527

Cited by 3 publications

(1 citation statement)

References 66 publications

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“…Additionally, when the YAP inhibitor verteporfin was added to this environment, the inhibitory effect of CTS on TNF‐α‐activated inflammation disappeared, suggesting that YAP might be a measure of CTS regulation of TNF‐α‐related inflammation. Since there was no significant change in YAP expression when treated with CTS without TNF‐α stimulation, the investigators suggested that CTS’ anti‐inflammatory effect only came into effect under inflammatory conditions rather than under resting conditions (Zhao, Behm, Tian, et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

Mechanisms of mechanical force aggravating periodontitis: A review

Liu

Yue

et al. 2023

Oral Diseases

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Periodontitis is a widespread oral disease accompanied by uncontrolled inflammation‐related tissue destruction. Periodontitis is related to various factors. Among them, occlusal trauma can aggravate the severity of periodontitis and has been attracting a great deal of attention. We systematically searched PubMed and Web of Science databases for related articles. Keywords for the search were “mechanical force”, “mechanical stress”, “occlusal trauma” and “periodontitis”. This review focuses on the effect of mechanical forces on periodontitis and discusses the possible pivotal targets participating in this process. We elucidated and summarized 21 articles that reported on our topic. Several biological processes and pathways that participate in enhancing the inflammatory response to mechanical stress have been studied, including the regulation of osteogenesis and osteoclastic resorption balance, Yes‐associated protein signaling, induction of collagen destruction, and regulation of programmed cell death. Mechanical force enhances the process of periodontitis in multiple ways. However, currently, no studies have further examined its underlying mechanism. Understanding the specific roles of mechanical forces may assist in the treatment of periodontitis with traumatic occlusal trauma.

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Section: Resultsmentioning

confidence: 99%

Mechanisms of mechanical force aggravating periodontitis: A review

Liu

Yue

et al. 2023

Oral Diseases

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Effects of mechanical loading on matrix homeostasis and differentiation potential of periodontal ligament cells: A scoping review

Pakpahan,

Kyawsoewin,

Manokawinchoke

et al. 2024

J of Periodontal Research

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Various mechanical loadings, including mechanical stress, orthodontics forces, and masticatory force, affect the functions of periodontal ligament cells. Regulation of periodontal tissue destruction, formation, and differentiation functions are crucial processes for periodontal regeneration therapy. Numerous studies have reported that different types of mechanical loading play a role in maintaining periodontal tissue matrix homeostasis, and osteogenic differentiation of the periodontal ligament cells. This scoping review aims to evaluate the studies regarding the effects of various mechanical loadings on the secretion of extracellular matrix (ECM) components, regulation of the balance between formation and destruction of periodontal tissue matrix, osteogenic differentiation, and multiple differentiation functions of the periodontal ligament. An electronic search for this review has been conducted on two databases; MEDLINE via PubMed and SCOPUS. Study selection criteria included original research written in English that reported the effects of different mechanical loadings on matrix homeostasis and differentiation potential of periodontal ligament cells. The final 204 articles were mainly included in the present scoping review. Mechanical forces of the appropriate magnitude, duration, and pattern have a positive influence on the secretion of ECM components such as collagen, as well as regulate the secretion of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases. Additionally, these forces regulate a balance between osteoblastic and osteoclast differentiation. Conversely, incorrect mechanical loadings can lead to abnormal formation and destruction of both soft and hard tissue. This review provides additional insight into how mechanical loadings impact ECM homeostasis and multiple differentiation functions of periodontal ligament cells (PDLCs), thus making it valuable for regenerative periodontal treatment. In combination with advancing technologies, the utilization of ECM components, application of different aspects of mechanical force, and differentiation potential of PDLCs could bring potential benefits to future periodontal regeneration therapy.

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Dependence of regional circulation in periodontal tissues on the condition of occlusive-articulatory disorders in patients with chronic generalized periodontitis

Tlustenko,

Trunin,

Tlustenko

et al. 2024

Russian Journal of Dentistry

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Introduction. The scientific substantiation of the causal relationships of traumatic occlusive forces and periodontal diseases is a difficult task and this issue is still debatable. According to available data, occlusive loads in the area of compression of periodontal ligaments lead to changes in blood circulation in lymphatic and blood vessels, which increase the inflammatory process when the adaptive capacity of the periodontal is exceeded. It is necessary to obtain additional information to choose tactics for reducing premature contacts in chronic generalized periodontitis. The aim of the study was to study the state of regional blood circulation in periodontal diseases with the elimination of occlusive obstacles by selective grinding of teeth. Results and discussion. 25 patients with occlusal interference before and after grinding were examined. In the study group, a decrease in the rheographic index by 41% and an increase in the time of rapid and slow blood filling by 1.5 and 1.6 times, respectively, before occlusive grinding were found. After the elimination of premature supracontacts, hemodynamic parameters changed in the opposite direction, the rheographic index increased, and the α1 and α2 indicators decreased. Other hemodynamic criteria studied approached the values in the comparison group. Conclusion. The results of the study confirm the expediency of minimally invasive interventions to eliminate occlusive interference in order to improve hemodynamics in periodontal tissues.

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Cyclic tensile strain-induced yes-associated protein activity modulates the response of human periodontal ligament mesenchymal stromal cells to tumor necrosis factor-α

Cited by 3 publications

References 66 publications

Mechanisms of mechanical force aggravating periodontitis: A review

Mechanisms of mechanical force aggravating periodontitis: A review

Effects of mechanical loading on matrix homeostasis and differentiation potential of periodontal ligament cells: A scoping review

Dependence of regional circulation in periodontal tissues on the condition of occlusive-articulatory disorders in patients with chronic generalized periodontitis

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