Cyclical Ovarian Function in Women with Congenital Absence of the Uterus and Vagina

Fraser, Ian S.; Baird, D. T.; Hobson, B. M.; Michie, Eileen A.; Hunter, W. M.

doi:10.1210/jcem-36-4-634

Cited by 60 publications

(30 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, it is unlikely to have a similar role in women because it is well established that after hysterectomy (Beavis, Brown & Smith, 1969) and in the congenital absence of Mullerian duct structures (Fallopian tubes, uterus, vagina) the cyclic ovarian function is maintained (Brown, Kellar & Matthew, 1959;Fraser, Baird, Hobson, Michie & Hunter, 1973). This paper has shown clearly that there is a cyclic variation in the levels…”

Section: Discussionmentioning

confidence: 79%

Levels of prostaglandins in human endometrium during the normal menstrual cycle

Downie¹,

Poyser²,

Wunderlich³

1974

The Journal of Physiology

213

View full text Add to dashboard Cite

SUMMARYThe levels of prostaglandins in the human endometrium throughout the normal menstrual cycle were measured by bioassay. The identity of prostaglandin F. and prostaglandin E2 in endometrial tissue extracts was established by combined gas chromatography/mass spectrometry.The levels of prostaglandin F2,, and prostaglandin E2 are low during the proliferative phase of the cycle (10-25 ng/100 mg tissue). Prostaglandin F2. rises significantly during the luteal phase to levels of 65-75 ng/100 mg of tissue. Prostaglandin E2 levels are similar to prostaglandin Fu levels in the proliferative phase but remain lower during the luteal phase. The prostaglandin E2 level is highest at menstruation (52 ng/100 mg tissue). The implications of these findings are discussed in relation to the menstrual process and to the steroid hormonal changes during the cycle.

show abstract

Section: Discussionmentioning

confidence: 79%

Levels of prostaglandins in human endometrium during the normal menstrual cycle

Downie¹,

Poyser²,

Wunderlich³

1974

The Journal of Physiology

213

View full text Add to dashboard Cite

show abstract

“…PGF-2ais now believed to be the uterine luteolytic agent in most species except primates (see Horton & Poyser, 1976, for review). Human luteal function appears to be independent of uterine control since neither hysterectomy (Beling, Marcus & Markham, 1970) nor congenital absence of Fallopian tubes, uterus and vagina (Fraser, Baird, Hobson, Michie & Hunter, 1973) disrupt cyclic ovarian function. PGF-2a in vitro, however, in cultured human granulosa cells (McNatty, Henderson & Sawers, 1975), or directly injected into the human ovary (Korda, Shutt, Smith, Shearman & Lyneham, 1975) reduces progesterone secretion, suggesting a possible intraovarian role for in man.…”

Section: Introductionmentioning

confidence: 99%

Prostaglandin E-2-9-ketoreductase in ovarian tissues

Watson¹,

Shepherd²,

Dodson³

1979

Reproduction

View full text Add to dashboard Cite

show abstract

“…Mainly in familial cases, MRKH is inherited as an autosomal dominant trait with variable expressivity and incomplete penetrance. 8 In women diagnosed with MRKH syndrome, levels of luteinizing hormone, plasmatic follicle stimulating hormone and 17ß-oestradiol are normal proving the integrity of ovarian function. 9 She had presented with karyotype 46, XX chromosome with normal development of secondary sexual characteristics and normal LH, FSH levels.…”

Section: Case Reportmentioning

confidence: 99%