Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland

Abstract

High cyclin A expression is a useful marker for the pathological diagnosis of CXPA.

Cyclin D1 and p16 expression in pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid gland

“…Our finding that cyclin D1 expression was undetectable in normal parotid tissues, but present in increasing proportions of benign and malignant tissues, was of particular interest. This trend parallels our findings for cyclin A 24 and provides preliminary evidence that the deregulation of cyclin D1 may be important in both the development of PA and its progression to CXPA. However, these findings should be interpreted with caution because of the small numbers.…”

“…Increasing our understanding of salivary gland tumour cell biology may provide important information for predicting response to current standard treatment regimens and may lead to identification of novel therapeutic gene targets. We recently reported that cyclin A, which has a role in G 1 /S as well as G 2 /M arrest, is significantly more likely to be expressed in PA than in CXPA, suggesting that high cyclin A expression may be a useful marker for the pathological diagnosis of CXPA 24 . This study extends these investigations by comparing levels of expression of cyclin D1 and p16 in normal tissue, PA and CXPA of the parotid gland.…”

Expression and prognostic significance of cyclin B1 and cyclin A in non‐small cell lung cancer

“…Cyclin A expression was also increased in CIS compared with normal epithelium, whereas expression in squamous metaplasia did not differ from normal bronchial epithelium and was significantly lower than in invasive carcinoma. Similarly, elevated cyclin A expression has been described in precursor lesions of oral SCC, 8 carcinomas ex pleomorphic adenoma of the parotid gland 43 and colorectal cancer 29 . This suggests cyclin A is involved in tumorigenesis prior to development of an invasive phenotype.…”

Overexpression of EGFR and absence of C‐KIT expression correlate with poor prognosis in salivary gland carcinomas

“…acinic cell carcinoma as a low‐grade carcinoma and salivary duct carcinoma as a high‐grade carcinoma. Additional immunohistochemistry has been shown to facilitate subtyping of salivary gland tumours, 2–4 but the value of immunohistochemistry in the assessment of prognosis is still a matter for debate. Frequently mentioned prognostic factors independent of histopathological tumour (sub)type include grade of malignancy, proliferative activity (Ki67), age, T‐stage, N‐stage, distant metastasis and therapeutic strategy 5–10 .…”