Cyclin A overexpression and survival in node-negative (N-) breast cancer patients

Baldini, Editta; Camerini, Andrea; Prochilo, Tiziana; Pasqualetti, F.; Orlandini, Cinzia; Capodanno, Alessandra; Salvadori, B; Collecchi, Paola

doi:10.1200/jco.2005.23.16_suppl.589

Cited by 24 publications

(29 citation statements)

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“…mitotic activity, thymidine labeling index, S-phase fraction, Ki67, and cyclins have been shown to be associated to prognosis and to response to chemotherapy [1][2][3][4][5][6][7]. Ki67 and mitotic activity have recently been included in the St Gallen guidelines [8], but the role of other proliferation markers, such as cyclin A, is still debated.…”

Section: Introductionmentioning

confidence: 99%

Combination of the proliferation marker cyclin A, histological grade, and estrogen receptor status in a new variable with high prognostic impact in breast cancer

Strand

Ahlin²,

Bendahl

et al. 2011

Breast Cancer Res Treat

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Section: Introductionmentioning

confidence: 99%

Combination of the proliferation marker cyclin A, histological grade, and estrogen receptor status in a new variable with high prognostic impact in breast cancer

Strand

Ahlin²,

Bendahl

et al. 2011

Breast Cancer Res Treat

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“…Breast cancer seems to be the best example, as the intense expression of cyclin A in primary tumour cells is proven to be associated with an increased risk of relapse, and poor response to treatment with tamoxifen [15]. Baldini et al [16] suggest using the expression of cyclin A as an additional factor to proceed in some patients into a group with high risk of relapse. Numerous studies have also demonstrated the usefulness of the evaluation of cyclin B1 expression as a prognostic factor for breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The staining signal of cyclin A was observed predominantly in the nuclei in 27% (n=11) of cases, in cytoplasm in 40% (16), and both in nuclei and cytoplasm in 23% (n=9) of the cases. In the group of classic variant of PTC, positive staining was observed in 80% of the cases (n=16/20).…”

Section: Cyclin a Expressionmentioning

confidence: 94%

Patterns of cyclin A and B1 immunostaining in papillary thyroid carcinoma

Cyniak-Magierska¹,

Stasiak²,

Naze³

et al. 2015

Ann Agric Environ Med.

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Introduction and objectives. Cyclin A, encoded by CCNA (cyclin A) gene with locus in chromosome 4q27, and cyclin B1, encoded by CCNB1 (cyclin B1) gene with locus in chromosome 5q12, are proteins that play a key role in the passage through the restriction point in G2 phase of the cell cycle. The aim of the study was to analyse immunohistochemically the expression of cyclins A and B1 in different variants of papillary thyroid carcinoma (PTC). Material and methods. The immunostaining patterns of the proteins in question in the tissue of 40 resected PTC (20 cases of classic variant of PTC, 9 cases of PTC follicular variant and 11 cases of other non-classic variants of PTC) were investigated. Results. On analyzing cyclin A and B1 expression, positive staining in 90% cases of PTC were observed. The study revealed a significant difference in expression of cyclins A and B1 between classic and non-classic variants of PTC. The expression of both examined cyclins was weaker in the classic variant of PTC. In the group of follicular variant of PTC, the expression of cyclins was of medium intensity and in the group of other non-classic variants of PTC, the expression was clearly higher. Conclusions.The results of the presented study suggest that cyclins A and B1 expression may have a characteristic pattern of immunostaining for particular variants of PTC. If the obtained results are confirmed in a larger group of patients, the diagnostic panel constructed of the antibodies against these proteins may increase the diagnostic accuracy in PTC cases.

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“…Cyclin D1 more than cyclin A2 has previously been shown to be implicated in human cancers [2,3]. In breast cancer, overexpression of cyclin A2 protein has shown an unfavourable impact on patient prognosis [4][5][6][7][8][9][10]. In colon cancer, however, the prognostic value varies among different studies, showing a favourable prognosis [11,12] and an unfavourable prognosis [13,14].…”

Section: Introductionmentioning

confidence: 99%

Cyclin A2 Protein Overexpression Is Not Caused by Gene Amplification in Colon Cancer

et al. 2012

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Increased expression of cyclin A2 protein has been detected in different types of cancers. However, its prognostic importance appears to differ between tumours. The significance and precise mechanisms behind cyclin A2 overexpression remain to be elucidated. We used real-time PCR to examine CCNA2 amplification in tumour cells isolated by laser microdissection and in total tumour tissue in colon cancer patients in which overexpression of cyclin A2 protein had been revealed by immunohistochemistry (n = 22 patients). The results were verified by FISH. CCNA2 amplification was not detected in either the isolated tumour cells or the total tumour tissue. We verified our methods by demonstrating amplification of CCNA2 by real-time PCR in three out of eight breast tumours that overexpressed cyclin A2 protein (this frequency is consistent with the findings of others). However, FISH did not reveal any CCNA2 amplification in the breast tumours, but it did reveal polysomy of chromosome 4 or segments of chromosome 4 in three tumour tissue samples, indicating the importance of verifying the real-time PCR results with another method. To conclude, the increased cyclin A2 protein expression in these patients could not be explained by CCNA2 amplification in isolated colonic tumour cells.

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Cyclin A overexpression and survival in node-negative (N-) breast cancer patients

Cited by 24 publications

References 0 publications

Combination of the proliferation marker cyclin A, histological grade, and estrogen receptor status in a new variable with high prognostic impact in breast cancer

Combination of the proliferation marker cyclin A, histological grade, and estrogen receptor status in a new variable with high prognostic impact in breast cancer

Patterns of cyclin A and B1 immunostaining in papillary thyroid carcinoma

Cyclin A2 Protein Overexpression Is Not Caused by Gene Amplification in Colon Cancer

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