2004
DOI: 10.1016/s0002-9440(10)63378-0
|View full text |Cite
|
Sign up to set email alerts
|

Cyclin-Dependent Kinase 5 Is a Regulator of Podocyte Differentiation, Proliferation, and Morphology

Abstract: Podocytes are highly specialized and terminally differentiated glomerular cells that play a vital role in renal physiology, including the prevention of proteinuria. Cyclin-dependent kinase 5 (CDK5) has been shown to influence several cellular processes in other terminally differentiated cells, in particular neurons. In this study, we examined the role of CDK5 in podocyte differentiation, proliferation, and morphology. In conditionally immortalized mouse podocytes in culture, CDK5 increased in association with … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

2
65
0

Year Published

2006
2006
2015
2015

Publication Types

Select...
9
1

Relationship

1
9

Authors

Journals

citations
Cited by 62 publications
(67 citation statements)
references
References 36 publications
2
65
0
Order By: Relevance
“…[48][49][50][51][52] After this point, podocytes are considered incapable of undergoing mitosis under normal conditions, although podocyte proliferation occurs in certain pathologic conditions, such as HIVassociated nephropathy. 53,54 Podocytes can be induced to proliferate in vitro when cultured from freshly isolated glomeruli, 55 but these cells express low levels of many of the podocyte-specific differentiation markers, suggesting that podocytes are only capable of proliferating after they have dedifferentiated to a certain degree.…”
Section: Discussionmentioning
confidence: 99%
“…[48][49][50][51][52] After this point, podocytes are considered incapable of undergoing mitosis under normal conditions, although podocyte proliferation occurs in certain pathologic conditions, such as HIVassociated nephropathy. 53,54 Podocytes can be induced to proliferate in vitro when cultured from freshly isolated glomeruli, 55 but these cells express low levels of many of the podocyte-specific differentiation markers, suggesting that podocytes are only capable of proliferating after they have dedifferentiated to a certain degree.…”
Section: Discussionmentioning
confidence: 99%
“…31,39,40 HDAC inhibitors are found to inhibit EMT of renal proximal tubular epithelial cells. 12,13,15,18 -21 Specifically, VPA is found to prevent EMT in NRK-52E cells, along with the selective class I HDAC inhibitor SK-7041, which indicates that class I HDACs play a pivotal role in EMT.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, an increasing number of features are described as being shared by the two cell types. First, podocytes and neurons are postmitotic terminally differentiated cells (Nagata et al 1998;Gubler 2003); second, they express common sets of proteins including synaptopodin (Mundel et al 1997;Czarnecki et al 2005), nephrin (Putaala et al 2001), cyclin-dependent kinase 5 (CDK5) (Griffin et al 2004), olfactomedin-related glycoprotein (Kondo et al 2000), a type III receptor protein tyrosine phosphatase (Beltran et al 2003), and Rab3A and Rabphilin-3a (Rastaldi et al 2003). Third, some transcription factors such as N-myc (Hirvonen et al 1989) and Wilms' tumor suppressor protein (Armstrong et al 1992) are at least transiently expressed either in neurons or podocytes.…”
mentioning
confidence: 99%