Cyclin-dependent kinase inhibitor 1B acts as a novel molecule to mediate testosterone synthesis and secretion in mouse Leydig cells by luteinizing hormone (LH) signaling pathway

Guo, Hongzhou; Luo, Xuan; Sun, Longjie; Li, Jianhua; Cui, Sheng

doi:10.1007/s11626-021-00545-x

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…FSH and LH bind with FSHR and LHR, respectively, to promote follicle maturation from prehierarchical follicles to preovulatory follicles and to induce testicular development. Moreover, FSH and LH increased the levels of P4, E2, androgens, and T in plasma ( Johnson and Lee, 2016 ; Guo et al, 2021 ). Cytokines, particularly AdipoQ, reportedly to regulate the expression of steroidogenesis genes ( StAR, CYP11A1, CYP19A1 , and 3BHSD ) and the secretion of steroid hormones in ovarian and testicular tissues of animals ( Ledoux et al, 2006 ; Chabrolle et al, 2007b ; Lagaly et al, 2008 ; Pierre et al, 2009 ; Ramanjaneya et al, 2011 ; Singh et al, 2014 ; Rak et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

The adiponectin receptor agonist, AdipoRon, promotes reproductive hormone secretion and gonadal development via the hypothalamic-pituitary-gonadal axis in chickens

Cao²,

Ren³

et al. 2023

Poultry Science

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Section: Discussionmentioning

confidence: 99%

The adiponectin receptor agonist, AdipoRon, promotes reproductive hormone secretion and gonadal development via the hypothalamic-pituitary-gonadal axis in chickens

Cao²,

Ren³

et al. 2023

Poultry Science

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“…Consequently, exerting a crucial influence on the male reproductive activities of rats [38,39]. Luteinizing hormone, or LH, is essential for the production and control of testosterone release by Leydig cells [40]. Codeine influences the activity of enzymes and works to inhibit metabolic processes such as glycolysis and protein synthesis and antioxidant pathways.…”

Section: Discussionmentioning

confidence: 99%

Effects of Quercetin on Codeine-Induced Reproductive Hormone Disorder

Mohammed,

Osama Adnan,

Abdaulteef Salih

2025

Egyptian Journal of Veterinary Sciences

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T HE CURRENT research studies quercetin's potential to attenuate its effects on adult male rats' codeine-induced reproductive disorders. Twenty-four male adult rats were separated into four sets, consisting of six male adult rats in every set, and a 56-day treatment was obtained. General, the first set is control, and the second set (Q1) obtained quercetin using a gavage needle administered at a specific dosage (300 mg/kg/day). In contrast, the third set (Q2) obtained codeine(50mg/kg/day) using a gavage needle, and the fourth group (Q3) obtained quercetin and codeine until 56 days. As a result of exposure to codeine, the rats› blood concentrations of luteinizing hormone (L.H.) and testosterone (T.) decreased. Nevertheless, the administration of quercetin caused an elevation in the levels of (L.H.) plus (T.) hormones in the set (Q3) compared with the set (Q2). In group (Q2), there were changes in the testicle›s structure and tissue, mainly in the Sertoli cells. In addition, there was amyloid accumulation inside the seminiferous tubules; these cells were disarrangements and lacked germ cells. Meanwhile, rats given quercetin (Q1) showed improvement in testicular histopathological abnormalities. The present study›s findings, taking quercetin with codeine (Q3), demonstrated that quercetin consumption can attenuate the harmful influences of exposure to codeine on male reproductive function. In conclusion, this study investigated quercetin›s capability to protect rat testis from the histological damage that codeine causes by oxidative stress.

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“…Основным регулятором тестикулярного стероидогенеза в клетках Лейдига является лютеинизирующий гормон, воздействующий на мембранный рецептор, связанный с G-белком, и запускающий каскад реакций с последующей активацией протеинкиназы А [9,10]. Протеинкиназа А является триггером рядя внутриклеточных процессов, в результате которых холестерол поступает из липидных капель в митохондрии, а также происходит повышение экспрессии генов, кодирующих ферменты тестикулярного стероидогенеза [28][29][30]…”

Section: обсуждение основного результата исследованияunclassified

Features of steroidogenesis in men with hypogonadism and type 2 diabetes

Роживанов

Чернова

Ioutsi

et al. 2022

Probl Endokrinol (Mosk)

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BACKGROUND: Type 2 diabetes mellitus (DM2) in men is associated with a high incidence of hypogonadism. Testosterone is a steroid hormone and one of the final metabolites of steroidogenesis, which causes interest in assessing the content of key steroid hormones, their precursors and metabolites in hypogonadal and eugonadal men with T2DM.AIMS: Assessment of the features of steroidogenesis in men with hypogonadism in T2DM using tandem mass spectrometry.MATERIALS AND METHODS: A full-design, cross-sectional, screening, single-center, non-interventional study included men with T2DM, who were he was treated in Endocrinology Research Centre, Moscow. The study was conducted from October 2021 to January 2022. Medical history assessment, physical examination with determination of body mass index (BMI), measurement of key steroid hormones, their precursors and metabolites by isotope dilution liquid chromatography/tandem mass spectrometry, glycated hemoglobin (HbA1c) were performed. The groups were compared using the Mann-Whitney U-test for quantitative indicators and χ² with Yates’ correction for qualitative ones. Correlation analysis was performed by the Spearman correlation method. When determining the criterion of statistical significance, the Bonferroni correction was applied.RESULTS: Patients with hypogonadism had statistically significantly more pronounced obesity compared with eugonadal men. In a comparative analysis of patients, depending on the presence of hypogonadism, there were statistically significantly lower levels of androgen precursors 17-hydroxypregnenolone and 17-hydroxyprogesterone in hypogonadal men. At the same time, a positive statistically significant correlation was found between total testosterone and 17-hydroxyprogesterone. In addition, 17-hydroxyprogesterone, although to a lesser extent, but positively correlated with other androgens - androstenedione (r=0,328; p<0,001) and dehydroepiandrosterone (r=0,183; p=0,004). >< 0,001) and dehydroepiandrosterone (r=0,183; p=0,004).CONCLUSIONS: In this investigation the prevalence of male hypogonadism in type 2 diabetes, determined by high-precision tandem mass spectrometry, was 69,5%. There was no effect of the disease on the mineralocorticoid and glucocorticoid links of adrenal steroidogenesis. Hypogonadism was associated with decreased levels of a number of testosterone precursors. The most significant of them was 17-hydroxyprogesterone, which can be considered as a marker of testicular steroidogenesis.

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Cyclin-dependent kinase inhibitor 1B acts as a novel molecule to mediate testosterone synthesis and secretion in mouse Leydig cells by luteinizing hormone (LH) signaling pathway

Cited by 5 publications

References 48 publications

The adiponectin receptor agonist, AdipoRon, promotes reproductive hormone secretion and gonadal development via the hypothalamic-pituitary-gonadal axis in chickens

The adiponectin receptor agonist, AdipoRon, promotes reproductive hormone secretion and gonadal development via the hypothalamic-pituitary-gonadal axis in chickens

Effects of Quercetin on Codeine-Induced Reproductive Hormone Disorder

Features of steroidogenesis in men with hypogonadism and type 2 diabetes

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