Cyclization of 4-ureidobutanoic acids in acetic anhydride

Avetisyan, S. A.; Korachov, S. L.; Azaryan, L. V.; Karapetyan, A. A.; Struchkov, Yu. T.

doi:10.1007/bf01171285

Cited by 4 publications

(1 citation statement)

References 2 publications

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“…In view of the ubiquity of this fragment in a variety of biologically active compounds, the synthesis of various analogs is important in gauging their potential as a source of chemotherapeutics. From the aforementioned line of reasoning, we directed our research towards the development of a new procedure for synthesis of various iminolactone derivatives . In this article, we report the successful synthesis of a number of N ‐substituted 2,5‐dihydrofurans 3 .…”

Section: Introductionmentioning

confidence: 99%

A Convenient and Efficient Approach for the Synthesis of New 2‐N‐substituted 2,5‐dihydrofuran‐3‐carboxamides

Tokmajyan

Karapetyan

2016

Journal of Heterocyclic Chem

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In order to obtain potent biological active compounds, a convenient and efficient method for the synthesis of compounds comprising 2‐imino‐2,5‐dihydrofuran, aromatic, sulfamoyl, and heterocyclic fragments has been presented. This environmentally friendly method was based on the reaction of 2‐imino‐2,5‐dihydrofuran‐3‐carboxamides with analgesic and sulfanilamide drugs and 4‐aminoantipyrine in glacial acetic acid and afforded high yields of the products.

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Section: Introductionmentioning

confidence: 99%

A Convenient and Efficient Approach for the Synthesis of New 2‐N‐substituted 2,5‐dihydrofuran‐3‐carboxamides

Tokmajyan

Karapetyan

2016

Journal of Heterocyclic Chem

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ChemInform Abstract: Cyclization of 4‐Ureidobutanoic Acids in Acetic Anhydride.

et al. 1995

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Synthesis of new 6‐(4‐chlorophenyl)perhydro‐1,3‐diazepine‐2,4‐diones via ureidobutyric acids

Guillon¹,

Sonnet²,

Dallemagne³

et al. 1998

Journal of Heterocyclic Chem

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Synthesis of new 6‐(4‐chlorophenyl)perhydro‐1,3‐diazepine‐2,4‐diones was accomplished starting from 4‐amino‐3‐(4‐chlorophenyl)butyric acid (Baclofen). The chemical pathway involved the cyclisation of various 3‐(4‐chlorophenyl)‐4‐ureidobutyric acids. However, none of the new derivatives retained the anticonvulsant activity of their six‐membered ring homologues, belonging to the phenylpyrimidinedione series which we recently described.

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Cyclization of 4-ureidobutanoic acids in acetic anhydride

Cited by 4 publications

References 2 publications

A Convenient and Efficient Approach for the Synthesis of New 2‐N‐substituted 2,5‐dihydrofuran‐3‐carboxamides

A Convenient and Efficient Approach for the Synthesis of New 2‐N‐substituted 2,5‐dihydrofuran‐3‐carboxamides

ChemInform Abstract: Cyclization of 4‐Ureidobutanoic Acids in Acetic Anhydride.

Synthesis of new 6‐(4‐chlorophenyl)perhydro‐1,3‐diazepine‐2,4‐diones via ureidobutyric acids

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