Cyclizative Condensations. I. 2-Methylindole with Acetone and Methyl Ethyl Ketone¹

Ultrasound assisted N-bromosuccinimde catalyzed one pot condensation approach for synthesis of Bis(indolyl)methanes from primary alcohols

“…The most common and conventional method for the synthesis of bis(indolyl)methanes involves condensation of aromatic aldehydes or ketones with indole in presence of either Bronsted or Lewis acids. 6,7 The major drawbacks of the methodology include use of excess of Lewis acids, expensive reagents, toxic solvents, harsh reaction conditions etc. In recent years Farhad Shirini et al 8 reported synthesis of bis(indolyl)methanes using aromatic aldehydes and indole with FeCl3-RiH as a catalyst.…”

An efficient synthesis of bis(indolyl)methanes and evaluation of their antimicrobial activities

“…HCl; [28 -30]) or Lewis acids (e.g. AlCl 3 , BF 3 ; [31,32]). These reactions have also been investigated using various triflates and chlorides [33 -36].…”

An eco-friendly procedure for the efficient synthesis of bis(indolyl)methanes in aqueous media

“…Thus, the synthesis of bis(indolyl)methanes has received an increasing attention in recent years. The simple method for the synthesis of this class of compounds involves the electrophilic substitution reaction of indoles with carbonyl compounds in the presence of protic [13] or Lewis acids [14][15][16]. However, these procedures suffer from certain limitations when acid sensitive substrates are used.…”