Cycloadditions of nitrile oxides and nitrones to 4,4-methylene-1-methylpiperidine: Studies in regio- and stereoselectivity

Study on regioselective synthesis of bioactive bis-spiropyrazolines using molecular orbital calculations

“…The most developed phenomenon for the synthesis of these compounds depends mainly on cycloaddition reaction to exocyclic double bonds [5][6][7][8][9]. 1,3-Dipolar cycloaddition reactions are considered the most successful process for the construction of five-membered ring containing spiro and bis-spiro-compounds due to high regioand stereo-selective properties of these reactions [10,11].…”

Synthesis and crystal structure determination of two dispiro compounds from laboratory x‐ray powder diffraction data

“…Several azaspiro-compounds were reported to be tachykinin antagonists and of particular use in the treatment of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia [6]. The most developed procedure for the synthesis of these compounds depends on a cycloaddition reaction to exocyclic double bonds [7][8][9][10]. Due to their high regio-and stereoselective properties, nitrilimines are considered very reactive 1,3dipoles and have been widely used for construction of numerous spiro-compounds [11][12][13][14].…”

A facile entry into a novel class of dispiroheterocycles through 1,3-dipolar cycloaddition

“…[1][2][3] The most developed avenue for the synthesis of these compounds depends on the cycloaddition to an exocyclic bond. [4][5][6] Although highly substituted spiropyrrolidines are known, there seems to be no report on the synthesis of dispiro substituted pyrrolidine heterocycles. 1,3-Dipolar cycloaddition provides a way for the synthesis of many dispiroheterocycles through the cycloaddition reaction of nonstabilised azomethine ylides with the olefinic dipolarophiles.…”