Cycloartane triterpene glycosides from astragalus trigonus

Gariboldi, Pierluigi; Pelizzoni, F.; Tatò, Marco; Verotta, Luisellá; El–Sebakhy, Nadia A.; Asaad, Aya M.; Abdallah, Rokia M.; Toaima, Soad M.

doi:10.1016/0031-9422(95)00544-h

Cited by 53 publications

(24 citation statements)

References 10 publications

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“…Some Astragalus species are also used as diuretics and for treatment of stomach ulcers, diabetes, nephritis, chronic bronchitis, postpartum urine retention and leprosy (Foster, 1998). In the course of our phytochemical investigation of the secondary metabolites from Astragalus species endemic to Egypt, a number of cycloartane saponins, oleanane saponins, flavonoids, isoflavans and spinocoumarins were isolated (El-Sebakhy et al, 2000;Gabriboldi et al, 1995;Orsini et al, 1994;Radwan et al, 2007;Verotta et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

Chemical constituents from Astragalus annularis Forssk. and A. trimestris L., Fabaceae

El-Hawiet¹,

Toaima²,

Asaad³

et al. 2010

Rev. bras. farmacogn.

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The phytochemical investigation of the aerial parts of Astragalus annularisForssk. and A. trimestris L., Fabaceae, growing in Egypt, resulted in the isolation of eight compounds, for the first time from these two species. These compounds were identified by chemical methods, NMR spectroscopy, UV spectroscopy as well as MS analysis. The antimicrobial activity of the isolated compounds were tested against Staphylococcus aureus, Esherichia coli and Candida albicans.

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Section: Introductionmentioning

confidence: 99%

Chemical constituents from Astragalus annularis Forssk. and A. trimestris L., Fabaceae

El-Hawiet¹,

Toaima²,

Asaad³

et al. 2010

Rev. bras. farmacogn.

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“…Administration of AGHE and AGRE at doses of 250 and 500mg/kg prior to CCl 4 significantly protected against the elevation of transaminases, ALP and bilirubin levels. The serum activities of ALT, AST and GGT in rats treated with AGHE at a dose of 250 mg/kg plus CCl 4 .05 mg/dl respectively), was highly significant. Silymarin treated animals also prevented the elevation of ALT, -AST, GGT, ALP and bilirubin (124.16±7.13 U/l, 112.93±6.13 U/l, 5.83±0.025 U/l, 329.16±9.77 U/l and 0.90±0.06 mg/dl respectively).…”

Section: Serum Biochemical's Assaysmentioning

confidence: 92%

“…Antioxidant mechanism could be an ameliorative factor in the protective effect of AGRE for CCl 4 -induced hepatotoxicity in rats. CCl 4 is a well-known hepatotoxicant model that is activated by CYP system and initiates oxidative and biochemical stress that ultimately damage liver and other tissues, including kidney, heart, lung, testis, brain and blood ( 4 showed focal hepatic haemorrhage, while AGHE (500mg/kg bw,) plus CCl 4 showed no histopathological changes. AGRE (250mg/kg bw,) plus CCl 4 showed slight kupffer cells activation, while AGHE (500mg/kg bw,), plus CCl 4 showed slight granularity of the cytoplasm of hepatocytes.…”

Section: Histopathological Studiesmentioning

confidence: 99%

Comparative Anti-Inflammatory and Hepatoprotective Activities of <i>Astragalus Gummifer</i> Labill Herb and Roots in Rats

Yusufoğlu¹,

Alam²,

Zaghloul³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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Background: The Astragalus gummifer (F. Fabaceae), herb and roots were studied for anti-inflammatory and hepatoprotective activities. Materials and method:The alcoholic extracts of Astragalus gummifer (F. Fabaceae), herb (AGHE), and roots (AGRE), were used for antiinflammatory and hepatoprotective activities in Wister rats. The effects of AGHE and AGRE were compared with the standard drugs Phenylbutazone and silymarin, for anti-inflammatory and hepatoprotective activities respectively. Result: Both extracts showed significant anti-inflammatory activity (P< 0.001). AGRE showed comparatively more significant hepatoprotective activity (P< 0.001), than AGHE (P< 0.05); at doses of 250 and 500 mg/kg body weight as manifested by lowering the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and total bilirubin. The hepatoprotective activity was, also, supported by total protein (TP), malondialdehyde (MDA), nonprotein sulfhydryls (NP-SH), and histo-pathological studies of liver tissue. Discussion: To the best of our knowledge, this is the first report of the anti-inflammatory and hepatoprotective activities of Astragalus gummifer.The results of present studies indicated that both AGHE and AGRE can be used in inflammatory conditions, while investigation supports the use of AGRE in cases that hepatoprotection are required in the hepatotoxic conditions. More supportive studies are required before clinical recommendation.

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“…To the best of our knowledge, there are no phytochemical studies on this species to date. In this article, we describe the isolation and structural elucidation of two new acylated tridesmosides of a 20,24-epoxycycloartane-type aglycone from the roots of A. armatus, named armatosides I (1) and II (2), together with two known cycloartane-type glycosides, trigonoside II (3) [6] and trojanoside H (4) [7]. The new compounds showed unique chemical substitutions which are not frequently found in the genus Astragalus.…”

mentioning

confidence: 97%

“…Also, cycloastragenol substituted by a 6-O-Xyl moiety was detected in few cases, viz. in A. trojanus, A. gilvus (Turkey), A. trigonus (Egypt), A. adsurgens, and A. sieversianus (China) [6] [10 -15]. When it was not free, the position 6 was generally substituted by a GlcO unit [7] [9 -11] [13] [15 -27].…”

mentioning

confidence: 99%

Two New Acylated Tridesmosidic Saponins from Astragalus armatus

Semmar

Miyamoto

Mrabet

et al. 2010

Helvetica Chimica Acta

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Two new tridesmosidic glycosides of (3b,6a,16b,20R,24S)-20,24-epoxycycloartane-3,6,16,25-tetrol (¼ cycloastragenol), armatosides I and II (1 and 2, resp.), were isolated from the roots of Astragalus armatus (Fabaceae) as well as the known bidesmosidic glycosides of cycloastragenol, trigonoside II (3) and trojanoside H (4). Their structures were elucidated as (3b,6a,16b,20R,24S) -3,6,16,25-tetrol (1), and (3b,6a,16b,20R,24S) 6,16,25-tetrol (2). These structures were established by extensive NMR and MS analyses and by comparison with literature data.Introduction. -Astragalus is a great legume genus including more than 2200 species growing worldwide [1]. Saponins with aglycones of the cycloartane-, lanostane-and oleanane-type were isolated from many Astragalus species, but the cycloartane glycosides dominate the triterpenoids of this genus [2] [3] (cycloartane ¼ 9,19-cyclolanostane). Among the cycloartane-type skeletons, cycloastragenol (also known as cyclosiversigenin and astramembrangenin) is the most widely distributed genin of the glycosides in Astragalus genus [2]. The identified saponins were found to be diversified by their glycosylation types, degrees, and attachment points at the genin; moreover, several of them were acetylated. These different structural characteristics lead to specific chemical traits which could be used as fingerprints to distinguish different Astragalus species from each other. Astragalus armatus Willd. (Fabaceae) is an endemic shrub species in the region of Maghreb. It mainly grows in arid regions where pastoral activity is important because of its low palatability [4] [5]. To the best of our knowledge, there are no phytochemical studies on this species to date. In this article, we describe the isolation and structural elucidation of two new acylated tridesmosides of a 20,24-epoxycycloartane-type aglycone from the roots of A. armatus, named armatosides I (1) and II (2), together with two known cycloartane-type glycosides, trigonoside II (3) [6] and trojanoside H (4) [7]. The new compounds showed unique chemical substitutions which are not frequently found in the genus Astragalus.

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Cycloartane triterpene glycosides from astragalus trigonus

Cited by 53 publications

References 10 publications

Chemical constituents from Astragalus annularis Forssk. and A. trimestris L., Fabaceae

Chemical constituents from Astragalus annularis Forssk. and A. trimestris L., Fabaceae

Comparative Anti-Inflammatory and Hepatoprotective Activities of <i>Astragalus Gummifer</i> Labill Herb and Roots in Rats

Two New Acylated Tridesmosidic Saponins from Astragalus armatus

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