Cyclobutane Pyrimidine Dimers asUV‐InducedDNALesions

Abstract

Introduction Synthesis of Uracil and Thymine CPDS as the Basis for the Development of Model Compounds CPD Cleavage Investigations Investigations with Covalently Linked Model Compounds Synthesis of Uracil and Thymine CPD Phosphoramidite Building Blocks 111 CPD Lesions Embedded in DNA Acknowledgment

Photoprotecting Uracil by Coupling with Lossy Nanocavities

“…Indeed, from S 2 min an intersystem crossing reaction can occur, potentially resulting in photodamage. 59 A previous work 14 also shows how the RNA environment of uracil further hinders the relaxation by stabilizing the S 2 min , resulting in a higher barrier to overcome and a substantially longer permanence time in S 2 . In the most optimistic prevision, namely for the isolated molecule, the time needed by the WP to start overcoming the barrier is about 120 fs, as shown in the population plot ( Figure 1 c).…”

“…Overcoming this barrier and reaching the conical intersection is vital to trigger the photoprotection mechanism, as the probability to incur photodamage is directly related to the permanence time in the S 2 min basin. Indeed, from S 2 min an intersystem crossing reaction can occur, potentially resulting in photodamage . A previous work also shows how the RNA environment of uracil further hinders the relaxation by stabilizing the S 2 min , resulting in a higher barrier to overcome and a substantially longer permanence time in S 2 .…”