Cyclodextrin‐Based Nanosponges for Improving Solubility and Sustainable Release of Curcumin

Gharakhloo, Mosayeb; Sadjadi, Samahe; Rezaeetabar, Mahdi; Askari, Fahimeh; Rahimi, Azam

doi:10.1002/slct.201904007

Cited by 36 publications

(20 citation statements)

References 51 publications

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“…The DSC thermogram of curcumin-loaded nanosponge compared to the plain nanosponge and curcumin is represented in Figure 5 b, and the disappearance of the curcumin endothermic peak indicates the formation of the inclusion complex and the encapsulation of curcumin inside the prepared nanosponges. Similar results were reported in the literature [ 56 , 60 ].…”

Section: Resultssupporting

confidence: 92%

“…The inclusion complex of curcumin with cyclodextrin polymer [ 23 , 51 , 52 , 53 , 54 ] and with cyclodextrin-based nanosponges [ 55 , 56 , 57 , 58 , 59 , 60 ] was studied thoroughly in previously published research and was reported to have an effect on the enhancement of curcumin solubility, release rate, stability, and cytotoxicity [ 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. However, there was no comparison between nanosponges and direct β-cyclodextrin complexations for curcumin.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation and Characterization of Curcumin-β-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation

2021

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Cyclodextrin polymers and cyclodextrin-based nanosponges have been widely investigated for increasing drug bioavailability. This study examined curcumin’s complexation stability and solubilization with β-cyclodextrin and β-cyclodextrin-based nanosponge. Nanosponges were prepared through the cross-linking of β-cyclodextrin with different molar ratios of diphenyl carbonate. Phase solubility experiments were conducted to evaluate the formed complexes and evaluate the potential of using β-cyclodextrin and nanosponge in pharmaceutical formulations. Furthermore, physicochemical characterizations of the prepared complexes included PXRD, FTIR, NMR, and DSC. In addition, in vitro release studies were performed for the prepared formulations. The formation of β-cyclodextrin complexes enhanced curcumin solubility up to 2.34-fold compared to the inherent solubility, compared to a 2.95-fold increment in curcumin solubility when loaded in β-cyclodextrin-based nanosponges. Interestingly, the stability constant for curcumin nanosponges was (4972.90 M−1), which was ten times higher than that for the β-cyclodextrin complex, where the value was 487.34 M−1. The study results indicated a decrease in the complexation efficiency and solubilization effect with the increased cross-linker amount. This study’s findings showed the potential of using cyclodextrin-based nanosponge and the importance of studying the effect of cross-linking density for the preparation of β-cyclodextrin-based nanosponges to be used for pharmaceutical formulations.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Evaluation and Characterization of Curcumin-β-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation

2021

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“…MPH and CYT were loaded in NSs using previously reported methods [ 57 ]. Briefly, 1 g of NS was dispersed in 50 mL of double-distilled water using a magnetic stirrer, and then, 20 mL each of MPH and CYT was added.…”

Section: Methodsmentioning

confidence: 99%

Cyclodextrin Nanosponges Inclusion Compounds Associated with Gold Nanoparticles for Potential Application in the Photothermal Release of Melphalan and Cytoxan

Salazar

Yutronic

Kogan

et al. 2021

IJMS

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This article describes the synthesis and characterization of β-cyclodextrin-based nano-sponges (NS) inclusion compounds (IC) with the anti-tumor drugs melphalan (MPH) and cytoxan (CYT), and the addition of gold nanoparticles (AuNPs) onto both systems, for the potential release of the drugs by means of laser irradiation. The NS-MPH and NS-CYT inclusion compounds were characterized using scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), energy dispersive spectroscopy (EDS), thermogravimetric analysis (TGA), UV–Vis, and proton nuclear magnetic resonance (1H-NMR). Thus, the inclusion of MPH and CYT inside the cavities of NSs was confirmed. The association of AuNPs with the ICs was confirmed by SEM, EDS, TEM, and UV–Vis. Drug release studies using NSs synthesized with different molar ratios of β-cyclodextrin and diphenylcarbonate (1:4 and 1:8) demonstrated that the ability of NSs to entrap and release the drug molecules depends on the crosslinking between the cyclodextrin monomers. Finally, irradiation assays using a continuous laser of 532 nm showed that photothermal drug release of both MPH and CYT from the cavities of NSs via plasmonic heating of AuNPs is possible.

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“…Several carrier materials have been described for liposoluble bioactive compounds, namely natural and synthetic polymers, lipid carriers and proteins, in the form of: (i) nanoand microparticles [5,94]; (ii) capsules [15]; (iii) films [149]; (iv) foams [150]; (v) hydrogels [151]; (vi) nanosponges [152]; (vii) liposomes [153] and (viii) emulsions [154]. Synthetic polymers, such as polyethylene glycol (PEG) and poly(lactic-co-glycolic) acid (PLGA) [155,156] have been described, however, the controversial safe administration of synthetic matters demonstrated the need for other biologically safe options [5].…”

Section: Challenges Of Liposoluble Compounds Deliverymentioning

confidence: 99%

Novel Micro- and Nanocellulose-Based Delivery Systems for Liposoluble Compounds

et al. 2021

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Poor aqueous solubility of bioactive compounds is becoming a pronounced challenge in the development of bioactive formulations. Numerous liposoluble compounds have very interesting biological activities, but their low water solubility, stability, and bioavailability restrict their applications. To overcome these limitations there is a need to use enabling delivering strategies, which often demand new carrier materials. Cellulose and its micro- and nanostructures are promising carriers with unique features. In this context, this review describes the fast-growing field of micro- and nanocellulose based delivery systems with a focus on the release of liposoluble bioactive compounds. The state of research on this field is reviewed in this article, which also covers the chemistry, preparation, properties, and applications of micro- and nanocellulose based delivery systems. Although there are promising perspectives for introducing these materials into various fields, aspects of safety and toxicity must be revealed and are discussed in this review. The impact of gastrointestinal conditions on the systems and on the bioavailability of the bioactive compounds are also addressed in this review. This article helps to unveil the whole panorama of micro- and nanocellulose as delivery systems for liposoluble compounds, showing that these represent a great promise in a wide range of applications.

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Cyclodextrin‐Based Nanosponges for Improving Solubility and Sustainable Release of Curcumin

Cited by 36 publications

References 51 publications

Evaluation and Characterization of Curcumin-β-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation

Evaluation and Characterization of Curcumin-β-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation

Cyclodextrin Nanosponges Inclusion Compounds Associated with Gold Nanoparticles for Potential Application in the Photothermal Release of Melphalan and Cytoxan

Novel Micro- and Nanocellulose-Based Delivery Systems for Liposoluble Compounds

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