Cyclodextrin‐Functionalized Monolithic Capillary Columns: Preparation and Chiral Applications

Adly, Frady G.; Antwi, Nana Yaa; Ghanem, Ashraf

doi:10.1002/chir.22550

Cited by 43 publications

(13 citation statements)

References 35 publications

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“…As a result, there is a great demand for technologies that can separate enantiomers/sterioisomers or directly generate homochiral molecules. Various fields have flourished from the stringent demands of medicine, including enantioselective/stereoselective recognition and adsorption, and asymmetric catalysis . In particular, a sensing platform that can rapidly discriminate between different enantiomers/stereoisomers is important and complementary to these fields because it will help ensure the homochirality of the reaction product.…”

Section: Figurementioning

confidence: 99%

“…Various fields have flourished from the stringent demands of medicine, including enantioselective/stereoselective recognition and adsorption, and asymmetric catalysis. [3][4][5][6][7][8][9][10] In particular, a sensing platform that can rapidly discriminate between different enantiomers/stereoisomers is important and complementary to these fields because it will help ensure the homochirality of the reaction product. In this paper, we describe a method to generate a low-cost, highly accurate sensor electrodes that can selectively detect relevant enantiomers and stereoisomers.Several methods have been developed to help realize enantioselective/stereoselective recognition.…”

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confidence: 99%

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Chiral Sensing with Mesoporous Pd@Pt Nanoparticles

Fang

Henzie

et al. 2017

ChemElectroChem

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Mesoporous Pd@Pt nanoparticles possess high surface areas while still maintaining electroconductivity and low potential for agglomeration. By introducing L‐ or D‐DOPA (3,4‐dihydroxyphenylalanine) enantiomers during the synthesis of the mesoporous Pd@Pt nanoparticles, we can create a Pt shell that is sensitive to the chirality of the DOPA molecule. We demonstrate sensitive electrochemical detection of DOPA enantiomers.

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Section: Figurementioning

confidence: 99%

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confidence: 99%

Chiral Sensing with Mesoporous Pd@Pt Nanoparticles

Fang

Henzie

et al. 2017

ChemElectroChem

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“…The direct synthesis of other single-isomer derivatives is more difficult, due to the number of theoretically possible isomers. Monosubstituted derivatives are used in catalysis, [38][39][40][41] separation techniques, [35,[42][43][44] biomedical applications, [45][46][47] nanotechnologies [37,48] and sensors, [49] or as components of supramolecular assemblies. However, scientists have been devoting great efforts to add more than one functional group to a CD skeleton.…”

Section: General Methods For Synthesis and Characterisation Of Monosumentioning

confidence: 99%

Monosubstituted Cyclodextrins as Precursors for Further Use

Řezanka

2016

Eur J Org Chem

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Cyclodextrin derivatives find use in a broad field of applications (e.g., nanomaterials, biomedical applications, catalysis, separation techniques, sensors etc.), with monosubstitution allowing cyclodextrins to be attached to various types of surfaces or for a new feature to be introduced onto a cyclodextrin skeleton (recognition, catalysis, …). Although an enormous number of monosubstituted cyclodextrin derivatives have been synthesised, this review focuses only on the synthesis of several interesting monosubstituted derivatives (allyl, cinnamyl, propargyl, formylmethyl, carboxymethyl, azido and amino) suitable for further modifications. These derivatives allow the synthesis of an unlimited number of desired cyclodextrin derivatives. Using a cyclodextrin derivative already monosubstituted with a suitable functional group is much easier than the optimisation of monosubstitution for every new cyclodextrin derivative desired.

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“…Among tested compounds, nomifensine and naproxen were baseline separated . Further data about the use of functionalized monolithic material with CDs are available in a recently published review …”

Section: Selected Applications Related To Chiral Separationmentioning

confidence: 99%

Chiral Separations using Miniaturized Techniques: State of the Art and Perspectives

Fanali

2016

Israel Journal of Chemistry

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The separation and analysis of chiral compounds is an important topic of research, because these analytes are involved in various processes, e.g., biological, pharmacological, human health, etc. Their separation has also been recently obtained utilizing microfluidic techniques, such as capillary electrophoresis (CE), electrochromatography (CEC), and capillary/nano‐liquid chromatography (CLC/nano‐LC). Enantiomeric separation is mainly obtained by applying the direct resolution method, where a chiral selector (CS) is present in the separation system, either added to the mobile phase (MP) or bonded to the stationary phase or to the capillary wall. Among the several CSs used in microfluidic techniques, cyclodextrins, proteins, peptides, glycopeptide antibiotics, and modified polysaccharides are the most employed. Microfluidic techniques can offer several advantages over conventional analytical tools, e.g., high efficiency, high mass sensitivity, and reduced volumes of MP and sample. Optimized methods have been applied in different fields, such as biomedical, food chemistry, environment, pharmaceutical, etc. Excellent results have been achieved in CE and nano‐LC. Although CEC can offer higher efficiency due to the use of a strong electroosmotic flow, its use is less popular than the other. This limitation can be explained with the limited number of the stationary phases (SPs) commercially available.

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Cyclodextrin‐Functionalized Monolithic Capillary Columns: Preparation and Chiral Applications

Cited by 43 publications

References 35 publications

Chiral Sensing with Mesoporous Pd@Pt Nanoparticles

Chiral Sensing with Mesoporous Pd@Pt Nanoparticles

Monosubstituted Cyclodextrins as Precursors for Further Use

Chiral Separations using Miniaturized Techniques: State of the Art and Perspectives

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