Cyclodextrin grafted calcium carbonate vaterite particles: efficient system for tailored release of hydrophobic anticancer or hormone drugs

Abstract

The porous cyclodextrin-CaCO3 microparticles are acting as the intelligent hydrophobic drug carriers, where the loaded drug is stable at blood pH but released at acidic pH (cancer cells) due to recrystallization of CaCO3 particles.

The mechanism of catalase loading into porous vaterite CaCO3 crystals by co-synthesis

“…The pure crystals can be utilized themselves or they can be used as templates to assemble functional structures with encapsulated proteins [34][35][36][37][38][39] as well as various hydrophilic and hydrophobic drugs. 17,33,[40][41][42][43][44] Biologically relevant particles assembled using the crystals can be made of pure proteins [45][46][47][48] or biologically relevant molecules such as polyethylene glycol 49,50 or temperature-sensitive polymers such as poly(N-isopropylacrylamide). 51 A number of bio-applications have been reported utilizing the crystals as carriers for photodynamic therapy, [52][53][54][55][56] transcutaneous delivery, 57 delivery into the brain bypassing the blood-brain barrier, 58 delivery of insulin 59,60 and vaccines, 61,62 and as carriers in alternative fields such as food industry.…”

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

“…Examples include cyclodextrin-CaCO 3 hybrids designed as carriers for hydrophobic drugs and hormones. 89 Carrageenan-CaCO 3 90 and mucin-CaCO 3 hybrids 91 were produced to host doxorubicin, etc. Besides enhancing loading capacity for small drugs, the inclusion of polymers inside crystals may also stabilise them and slow down the VCC recrystallization to calcite that is important for modulating the drug release profile.…”

Utilization of a CO2 Storage Material: Shape-Controlled Preparation of CaCO3 Microspheres

“…In general, there are four modes for the characteristic vibrations of the C-O bond of CaCO3 crystals in FTIR spectra, which are the symmetric stretching mode, the out-of-plane bending mode, the doubly asymmetric stretching mode, and the doubly in-plane bending mode [38][39][40]. As shown in Figure 3b, two characteristic peaks at 875 and 711 cm −1 were observed, which was due to the υ4 In general, there are four modes for the characteristic vibrations of the C-O bond of CaCO 3 crystals in FTIR spectra, which are the symmetric stretching mode, the out-of-plane bending mode, the doubly asymmetric stretching mode, and the doubly in-plane bending mode [38][39][40]. As shown in Figure 3b, two characteristic peaks at 875 and 711 cm −1 were observed, which was due to the υ 4 mode of calcite in the sample A.…”