Cyclodextrin Metal–Organic Frameworks as a Drug Delivery System for Selected Active Pharmaceutical Ingredients

Abstract

The cyclodextrin-based metal−organic frameworks (CD MOFs) are a suitable molecular platform for drug delivery systems of various active pharmaceutical ingredients (APIs). The low toxicity and cost-efficient synthesis make CD MOFs an attractive host for the encapsulation of APIs. In this study, we created a model system based on γCD-K MOFs with widely used drugs carmofur (HCFU), 5fluorouracil (5-FU), and salicylic acid (HBA) to study host−guest encapsulation methods using different crystallization protocols. The host−guest complexes of API:CD MOF in an in-depth study were investigated by liquid chromatography−mass spectrometry (LC-MS), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and 19 F-and 13 C-detected solid-state NMR spectroscopy (ssNMR). These techniques confirmed the structure and interaction sites within the encapsulation product in the host−guest complex. We also evaluated the toxicity and biocompatibility of the API:CD MOF complex using in vitro and in vivo methods. The cytotoxicity, hepatotoxicity, and neurotoxicity were established with cell lines of fibroblasts (BJ), human liver cell line (HepG2), and human oligodendrocytic cells (MO3.13). Then, Danio rerio was used as an in vivo experimental model of ecotoxicity. The results showed the choice of γCD-K-5 as the most protective and safe option for drug encapsulation to decrease its toxicity level against normal cells.

Oral Synergism of Egg-White-Derived Peptides (EWDP) and Curcumin for Colitis Mitigation via Polysaccharide/Cyclodextrin Metal–Organic Framework-Based Assemblies

“…This phenomenon suggested that CMCS and EWDP could collaborate to facilitate the entrapment of Cur molecules in MOF-based assemblies, which was in agreement with prior discussions (Figure g,h). Meanwhile, Cur (especially for benzene ring regions) was mainly loaded into the porous microstructure and hydrophobic cavities of MOF via hydrogen bonding and hydrophobic interaction. , Similarly, the typical peaks (1677, 1643, and 1517 cm –1 ) of EWDP also dissipated in CMCS-EWDP-MOF-Cur, indicating the excellent coencapsulation efficiency of nutraceuticals within assemblies. To sum up, the coassembled CMCS-EWDP complex could provide an ideal load of dual nutraceuticals for MOF-based assemblies via tailoring main noncovalent interactions (hydrogen bonding, hydrophobic interaction, and electrostatic interaction).…”

Facile recovery of terephthalic acid from PET bottles via acid hydrolysis with nitric acid and applications in synthesis of cobalt MOFs

“…Usually, the ordered structure is crystalline, with high surface area [2]. The structure arrangements create pores and adjustable properties that allows a wide range of applications [3], such as photocatalysis [3][4][5], small molecule storage and separation and separation [6-8], drug delivery [9][10][11], chemical sensing and others [12].…”