Cyclodextrin Nanosponges in Drug Delivery and Nanotherapeutics

Osmani, Riyaz Ali M.; Kulkarni, Parthasarathi K.; Manjunatha, S. S.; Gowda, Vishakante; Hani, Umme; Vaghela, Rudra; Bhosale, Rohit R.

doi:10.1007/978-3-319-76090-2_9

Cited by 17 publications

(16 citation statements)

References 175 publications

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“…Cyclodextrins (hereinafter referred to as CDs) are cyclic oligosaccharides composed of α- d -glucopyranose units combined with α-(1→4)-glycosidic bonds. Native CDs are a product of the enzymatic degradation of starch, in which cyclodextrin glycosyltransferases produce cyclic oligomers consisting of six (α-CD), seven (β-CD, Figure 2 a), or eight (γ-CD) glucose units [ 21 , 22 , 23 , 24 ]. Due to restricted rotation of glycosidic bonds and the chair conformation of each glucose unit, CDs possess the specific shape of a truncated cone with a hollow cavity ( Figure 2 b) [ 23 , 24 , 25 , 26 , 27 ].…”

Section: Cyclodextrin-based Drug Delivery Systems—a Short Summarymentioning

confidence: 99%

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Exploring Cyclodextrin-Based Nanosponges as Drug Delivery Systems: Understanding the Physicochemical Factors Influencing Drug Loading and Release Kinetics

Pyrak,

Rogacka-Pyrak,

Gubica

et al. 2024

IJMS

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Cyclodextrin-based nanosponges (CDNSs) are complex macromolecular structures composed of individual cyclodextrins (CDs) and nanochannels created between cross-linked CD units and cross-linkers. Due to their unique structural and physicochemical properties, CDNSs can possess even more beneficial pharmaceutical features than single CDs. In this comprehensive review, various aspects related to CDNSs are summarized. Particular attention was paid to overviewing structural properties, methods of synthesis, and physicochemical analysis of CDNSs using various analytical methods, such as DLS, PXRD, TGA, DSC, FT-IR, NMR, and phase solubility studies. Also, due to the significant role of CDNSs in pharmaceutical research and industry, aspects such as drug loading, drug release studies, and kinetics profile evaluation of drug–CDNS complexes were carefully reviewed. The aim of this paper is to find the relationships between the physicochemical features and to identify crucial characteristics that are influential for using CDNSs as convenient drug delivery systems.

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Section: Cyclodextrin-based Drug Delivery Systems—a Short Summarymentioning

confidence: 99%

“…On the other hand, the hydrophilic outer surface is responsible for increasing drug solubility through interactions with aqueous media via hydroxyl groups. Thus, CDs are great candidates for drug transport systems [ 21 , 23 , 24 , 25 , 26 , 30 , 31 , 35 ].…”

Section: Cyclodextrin-based Drug Delivery Systems—a Short Summarymentioning

confidence: 99%

Exploring Cyclodextrin-Based Nanosponges as Drug Delivery Systems: Understanding the Physicochemical Factors Influencing Drug Loading and Release Kinetics

Pyrak,

Rogacka-Pyrak,

Gubica

et al. 2024

IJMS

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“…To be properly entrapped within nanocavities, drug molecules are required to comply with specific properties such as simple to trap molecules, molecular mass between 100 and 400 Da, and fewer than five condensed rings. Additionally, the molecules should possess a melting point of around or less than 250 °C with solubility in water of not more than 10 mg/mL (Osmani et al, 2018a). Higher melting points of pharmaceuticals make it difficult to develop stable complexes between medicines and niacin due to the need to maintain higher stability constant values after loading in the NS.…”

Section: Type Of Drugs and Medium Used For Crosslinkingmentioning

confidence: 99%

Unleashing the potential of cyclodextrin-based nanosponges in management of colon cancer: A review

Mohite,

Munde,

Pawar

et al. 2024

Nanofab

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Colon cancer ranked second in terms of incidence in the world, yearly it shows an increase in the tendency of mortality. It is estimated that by the year 2035 total number of deaths will increase by 75 %. The treatment of cancer includes surgery, radiation therapy, and chemotherapy, however, they are limited due to their targeted therapeutic potential and side effects. In the case of a conventional drug delivery system, it is desired that the drug delivery system should be able to protect the therapeutic from degradation and safety target to the desired site. Cyclodextrin-based nanosponges (NS) are a versatile platform for colon cancer treatment, surpassing the limitations of conventional drug delivery systems. Nanosponge offers several advantages such as improved drug solubility, enhanced stability, targeted delivery, and potential for combination therapy due to its highly cross-linked structure. The fabrication of NS includes the use of biopolymers for the controlled release of drugs from pores through diffusion. These pores can efficiently encapsulate a wide range of therapeutic agents, enabling regulated release, and addressing challenges associated with poor solubility and limited stability of drugs used in the management of colon cancer. Additionally, their functionalization enables targeted drug delivery to colon cancer cells, minimizing off-target effects. Though several benefits are associated with NS, further research is needed to address regulatory considerations and scale up NS for translation into clinical practice. Overall, cyclodextrin-based NS holds promise in revolutionizing colon cancer treatment and improving patient outcomes.

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“…This inner phase is added to PVA solution and stirred. The product is filtered out and dried [59]. Salunke et al [60] prepared budesonide-loaded nanosponges by quasi-emulsion solvent diffusion method.…”

Section: Quasi-emulsion Solvent Diffusionmentioning

confidence: 99%

Recent Pharmaceutical Developments in the Treatment of Cancer Using Nanosponges

Gore¹,

Bhattacharya²,

Prajapati³

2023

Advanced Drug Delivery Systems

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Nanosponges are a class of nanoparticles characterized by their sponge-like surface that ensures high loading capacity. Cancer causes high mortality and requires precise treatment without harming the body. Hence, nanoparticles are required to target medications to tumor. Nanosponges may be synthesized from various polymers and metals, giving them distinct properties. The majority of polymer synthesis entails crosslinking, while metal synthesis entails the isolation of metal nanoparticles accompanied by their assembly into sponges. Nanosponges must be functionalized to precisely attack tumors. There are several patents on nanosponges synthesis and their use. Future trends in the usage of nanosponges include simultaneous distribution of several molecules and expanding the spectrum of use from medicinal delivery to substance encapsulation for a multitude of applications. As their usage in the pharmaceutical industry grows, more emphasis should be put on toxicity-related aspects induced by the near association of cell membrane and nanosponge resulting in intracellular dissolution or reactive oxygen species (ROS) generation, which in turn damages various cellular components. Many techniques have been created to reduce toxicity, including functionalization with various materials such as antioxidants, polymers and altering nanosponges composition. As the application of nanosponges increases in many industries, the phenomenon related to toxicity must be further explored through research.

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Cyclodextrin Nanosponges in Drug Delivery and Nanotherapeutics

Cited by 17 publications

References 175 publications

Exploring Cyclodextrin-Based Nanosponges as Drug Delivery Systems: Understanding the Physicochemical Factors Influencing Drug Loading and Release Kinetics

Exploring Cyclodextrin-Based Nanosponges as Drug Delivery Systems: Understanding the Physicochemical Factors Influencing Drug Loading and Release Kinetics

Unleashing the potential of cyclodextrin-based nanosponges in management of colon cancer: A review

Recent Pharmaceutical Developments in the Treatment of Cancer Using Nanosponges

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