Cyclodextrin-polyhydrazine degradable gels for hydrophobic drug delivery

Jalalvandi, Esmat; Cabral, Jaydee; Hanton, Lyall R.; Moratti, Stephen C.

doi:10.1016/j.msec.2016.06.058

Cited by 36 publications

(28 citation statements)

References 58 publications

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“…As previously reported, the swelling index depends on the nature of the polymer, the average molecular weight, the rigidity of the polymer chain, the degree of crosslinking, and the network mesh size as well as external conditions, such as pH and temperature. 29,30 Moreover, the swelling index observed could be related with the absorption mechanism, which is determined by the diffusion process of water into the pores of hydrogel. 31 Furthermore, different swelling capacities were evaluated according to the pH of the solutions, as depicted in Figure 4.…”

Section: Molecular Dynamics Simulation Resultsmentioning

confidence: 99%

Methamidophos removal from aqueous solutions using a super adsorbent based on crosslinked poly(vinyl alcohol) hydrogel

Valdés

Ávila-Salas

Maricán

et al. 2017

J of Applied Polymer Sci

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This study describes the absorption of methamidophos (MMP) from aqueous solution by crosslinked poly(vinyl alcohol) (PVA) hydrogel synthesized using malic acid (MA) as a crosslinker (CLPHMA). The prepared hydrogels were characterized by FTIR spectroscopy, scanning electron microscopy, and the thermal properties were studied by using thermal gravimetric analysis. Also, the swelling index as a function of PVA:MA composition and pH were studied. An in silico rational study, which involved all‐atom molecular dynamics simulations of PVA:MA systems in proportions 10:2, 10:4, and 10:6 was performed. The in silico studies concluded that the more suitable crosslinking degree for MMP pesticide removal is with the 20% (wt %) of crosslinker (CLPHMA‐20). The experimental analysis of MMP removal with CLPHMA was performed as well. It was found that the prepared CLPHMA‐20 had a great efficiency to recover around 86% of MMP from their solutions. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45964.

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Section: Molecular Dynamics Simulation Resultsmentioning

confidence: 99%

Methamidophos removal from aqueous solutions using a super adsorbent based on crosslinked poly(vinyl alcohol) hydrogel

Valdés

Ávila-Salas

Maricán

et al. 2017

J of Applied Polymer Sci

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“…bCDs are being widely employed as solubilizing agent for poorly water‐soluble drugs and to enhance the bioavailability of class II and IV compounds of the Biopharmaceutical Classification System (BSC), thanks to the unique capability to form stable complexes in aqueous media through “host–guest” inclusion phenomena . The use of bCDs in pharmaceutics has been extended also for class I and III BSC compounds, especially for treatments requiring prolonged and controlled release profiles, as in the case of antimicrobial and antibiotic treatments .…”

Section: Resultsmentioning

confidence: 99%

An Injectable System for Local and Sustained Release of Antimicrobial Agents in the Periodontal Pocket

Morelli

Cappelluti

Ricotti

et al. 2017

Macromolecular Bioscience

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Periodontitis treatments usually require local administration of antimicrobial drugs with the aim to reduce the bacterial load inside the periodontal pocket. Effective pharmaceutical treatments may require sustained local drug release for several days in the site of interest. Currently available solutions are still not able to fulfill the clinical need for high-quality treatments, mainly in terms of release profiles and patients' comfort. This work aims to fill this gap through the development of an in situ gelling system, capable to achieve controlled and sustained release of antimicrobial agents for medium-to-long-term treatments. The system is composed of micrometer-sized β-cyclodextrin-based hydrogel (bCD-Jef-MPs), featured by a strong hydrophilic character, suspended in a synthetic block-co-polymer solution (Poloxamer 407), which is capable to undergo rapid thermally induced sol-gel phase transition at body temperature. The chemical structure of bCD-Jef-MPs was confirmed by cross-correlating data from Fourier transform infrared (FTIR) spectroscopy, swelling test, and degradation kinetics. The thermally induced sol-gel phase transition is demonstrated by rheometric tests. The effectiveness of the described system to achieve sustained release of antimicrobial agents is demonstrated in vitro, using chlorhexidine digluconate as a drug model. The results achieved in this work disclose the potential of the mentioned system in effectively treating periodontitis lesions.

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“…Synthesis of mono (6-amino-6-deoxy)-β-CD, CD functionalized alginate and methacrylated gelatin 2.3.1. Mono (6-amino-6-deoxy)-β-CD or EDA-β-CD EDA-β-CD was synthesized through a two-step reaction according to the reported procedure (Jalalvandi et al, 2016;Jalalvandi et al, 2017). First, a monotosyl derivative of β-CD was prepared by the reaction of ptoluene sulfonyl chloride with β-CD in water.…”

Section: Instrumentationmentioning

confidence: 99%

“…Of various types of crosslinking methods, injectable hydrogels are particularly interesting for clinical use. These hydrogels are applied through a syring and undergo a sol-gel transition at the site of injection where they can fit the geometry of target site, through a minimally invasive procedure (Jalalvandi et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Shear thinning/self-healing hydrogel based on natural polymers with secondary photocrosslinking for biomedical applications

Jalalvandi

Shavandi

2019

Journal of the Mechanical Behavior of Biomedical Materials

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Cyclodextrin-polyhydrazine degradable gels for hydrophobic drug delivery

Cited by 36 publications

References 58 publications

Methamidophos removal from aqueous solutions using a super adsorbent based on crosslinked poly(vinyl alcohol) hydrogel

Methamidophos removal from aqueous solutions using a super adsorbent based on crosslinked poly(vinyl alcohol) hydrogel

An Injectable System for Local and Sustained Release of Antimicrobial Agents in the Periodontal Pocket

Shear thinning/self-healing hydrogel based on natural polymers with secondary photocrosslinking for biomedical applications

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