Cyclodextrins and Cellular Interactions

Dreyfuss, J; Oppenheimer, Steven B.

doi:10.1002/9780470926819.ch15

Cited by 3 publications

(2 citation statements)

References 86 publications

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“…α-CD is a cyclic oligosaccharide with six D-(+)-glucose units linked together in α-1,4 fashion. It possesses a hydrophilic outer surface and a hydrophobic inner cavity that participates in host–guest interaction . The host–guest interaction between α-CD and higher molecular weight PEG leads to polypseudorotaxane formation that in turn induces formation of a thixotropic hydrogel. ,, In this article, we deliberately applied a low solid content at 1% PEG and 8% α-CD in the hydrogel formulation to highlight the impact and function of ECD/pDNA polyplexes toward the gelation process and hydrogel properties.…”

Section: Resultsmentioning

confidence: 99%

Supramolecular Anchoring of DNA Polyplexes in Cyclodextrin-Based Polypseudorotaxane Hydrogels for Sustained Gene Delivery

et al. 2012

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A cyclodextrin-based supramolecular hydrogel system with supramolecularly anchored active cationic copolymer/plasmid DNA (pDNA) polyplexes was studied as a sustained gene delivery carrier. A few biodegradable triblock copolymers of methoxy-poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly[2-(dimethylamino)ethyl methacrylate] (MPEG-PCL-PDMAEMA) with well-defined cationic block lengths were prepared to condense pDNA. The MPEG-PCL-PDMAEMA copolymers exhibit good ability to condense pDNA into 275-405 nm polyplexes with hydrophilic MPEG in the outer corona. The MPEG corona imparted greater stability to the pDNA polyplexes and also served as an anchoring segment when the pDNA polyplexes were encapsulated in α-CD-based supramolecular polypseudorotaxane hydrogels. More interestingly, the resultant hydrogels were able to sustain release of pDNA up to 6 days. The pDNA was released in the form of polyplex nanoparticles as it was bound electrostatically to the cationic segment of the MPEG-PCL-PDMAEMA copolymers. The bioactivity of the released pDNA polyplexes at various durations was further investigated. Protein expression level of pDNA polyplexes released over the durations was comparable to that of freshly prepared PEI polyplexes. Being thixotropic and easily prepared without using organic solvent, this supramolecular in situ gelling system has immense potential as an injectable carrier for sustained gene delivery.

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Section: Resultsmentioning

confidence: 99%

Supramolecular Anchoring of DNA Polyplexes in Cyclodextrin-Based Polypseudorotaxane Hydrogels for Sustained Gene Delivery

et al. 2012

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“…Here we continue exploration of Dominique's program and other high school level student research as well as college level research. We examine the nuts and bolts of the logistics of Presidential Awards at both [8][9].…”

Section: Introductionmentioning

confidence: 99%

US Presidential Awards: An Outcomes Analysis

Oppenheimer¹,

Evans-Bye²,

Berman³

et al. 2023

FET

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Around 99% of U.S. Presidential Awards for mentored student research in science go to college level mentors like Steve Oppenheimer. We have an opportunity here to describe the research and mentorship outcomes of two US Presidential Awardees. One is Steve and the other is a high school teacher, Dominique Evans-Bye, who also achieved a US Presidential Award for mentored student research in science. Dominique is one of only about two at the high school level, of hundreds in decades given at the college level. Because of the rarity of high school Presidential award winners, we show here what can be done at the high school level. And we show how vastly different, yet similar, university and high school programs can be. We believe that this paper is the only one ever to explore university and high school mentored student research in one place. We also review high school student research from the New Journal of Student Research Abstracts and show that it is sometimes every bit as good as university level research and should be considered an important part of the U.S. research effort. This may be the first time such a statement has been made. This review from our lab should help others understand what goes into a U.S. Presidential Award, the highest White House mentoring award in the nation, administered by the National Science Foundation. The important accomplishments of Dominique will help high school and middle school teachers enhance their student research programs if they choose to do so. Motivation is key.

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Energetic and thermodynamical aspects of the cyclodextrins-cannabidiol complex in aqueous solution: a molecular-dynamics study

Silva

Santos

2020

Eur Biophys J

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Cyclodextrins and Cellular Interactions

Cited by 3 publications

References 86 publications

Supramolecular Anchoring of DNA Polyplexes in Cyclodextrin-Based Polypseudorotaxane Hydrogels for Sustained Gene Delivery

Supramolecular Anchoring of DNA Polyplexes in Cyclodextrin-Based Polypseudorotaxane Hydrogels for Sustained Gene Delivery

US Presidential Awards: An Outcomes Analysis

Energetic and thermodynamical aspects of the cyclodextrins-cannabidiol complex in aqueous solution: a molecular-dynamics study

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