Cyclodextrins as resveratrol carrier system

Lucas-Abellán, Carmen; Fortea, Isabel; López‐Nicolás, José Manuel; Núñez-Delicado, Estrella

doi:10.1016/j.foodchem.2006.10.068

Cited by 138 publications

(99 citation statements)

References 24 publications

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“…The preservation of the antioxidant activity after three months storage in nanoencapsulated form suggests that lipidic nanoemulsions can present a solution to the problem of instability of resveratrol, which was reported to be easily oxidized (Frozza et al, 2011). This also came in accordance with several other authors (Lucas-Abellán et al, 2007;Caddeo et al, 2008;Coimbra et al, 2011;Sessa et al, 2014), who declared that encapsulation of resveratrol in carriers, such as cyclodextrin complexes, liposomes and lecithin-based nanoemulsions were able to improve the stability of resveratrol. Similarly, this could be applied to curcumin, in which authors reported that its encapsulation in nanoformulations improves its stability (Rachmawati et al, 2015).…”

Section: Stability Of the Selected Nanoemulsion Formulasupporting

confidence: 86%

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

Nasr

2015

Drug Delivery

170

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RESEARCH ARTICLEDevelopment of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery Maha NasrDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt AbstractThe development of mucoadhesive lipidic nanoemulsion based on hyaluronic acid, co-encapsulating two polyphenols (resveratrol and curcumin) for the transnasal treatment of neurodegenerative diseases was attempted in the current manuscript. Nanoemulsions were prepared by the spontaneous emulsification method, and were characterized for their particle size, zeta potential, mucoadhesive strength and morphology. The selected formula was tested for its antioxidant potential, in vitro and ex vivo release of the two polyphenols, safety on nasal mucosa and in vivo quantification of the two drugs in rat brains. Its stability was tested by monitoring the change in particle size, zeta potential, drugs' content and antioxidant potential upon storage for 3 months. The optimized hyaluronic acid based nanoemulsion formula displayed a particle size of 115.2 ± 0.15 and a zeta potential of À23.9 ± 1.7. The formula displayed a spherical morphology and significantly higher mucoadhesive strength compared to its non mucoadhesive counterpart. In addition, the nanoemulsion was able to preserve the antioxidant ability of the two polyphenols and protect them from degradation. Diffusion controlled release of the two drugs was achievable till 6 hours, with an ex vivo flux across sheep nasal mucosa of 2.86 and 2.09 mg/cm 2 hr for resveratrol and curcumin, respectively. Moreover, the mucoadhesive nanoemulsion was safe on nasal mucosa and managed to increase the amounts of the two polypehnols in the brain (about 7 and 9 folds increase in AUC 0-7 h for resveratrol and curcumin, respectively). Hyaluronic acid based lipidic nanoemulsion proved itself as a successful carrier enhancing the solubility, stability and brain targetability of polyphenols.

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Section: Stability Of the Selected Nanoemulsion Formulasupporting

confidence: 86%

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

Nasr

2015

Drug Delivery

170

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“…The coated pellets were mounted onto stubs using double sided adhesive tape. The samples were sputter coated with platinum-palladium (80: 20) in an argon atmosphere and examined at 15 kV accelerating voltage.…”

Section: Characterization Of Resveratrol Ns Complexesmentioning

confidence: 99%

“…However, due to hydrophobicity, dissolution is a ratelimiting step for in vivo absorption, which constitutes the serious problem for oral bioavailability (18), the extensive research has been carried out to overcome this problem (19,20).…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin-Based Nanosponges for Delivery of Resveratrol: In Vitro Characterisation, Stability, Cytotoxicity and Permeation Study

et al. 2011

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Abstract. The aim of this work was to increase the solubility, stability and permeation of resveratrol by complexation with cyclodextrin-based nanosponges (NS). Nanosponges are recently developed hypercross-linked cyclodextrin polymers nanostructured to form three-dimensional networks; they are obtained by reacting cyclodextrin with a cross-linker such as carbonyldiimidazole. They have been used to increase the solubility and stability of poorly soluble actives. This study aimed at formulating complexes of resveratrol with β-cyclodextrin nanosponges in different weight ratios. DSC, FTIR and Xray powder diffraction (XRPD) studies confirmed the interaction of resveratrol with NS. XRPD showed that the crystallinity of resveratrol decrease after encapsulation. The particle sizes of resveratrol-loaded NS are in between 400 to 500 nm with low polydispersity indices. Zeta potential is sufficiently high to obtain a stable colloidal nanosuspension. TEM measurement also revealed a particle size around 400 nm for NS complexes. The in vitro release and stability of resveratrol complex were increased compared with plain drug. Cytotoxic studies on HCPC-I cell showed that resveratrol formulations were more cytotoxic than plain resveratrol. The permeation study indicates that the resveratrol NS formulation showed good permeation in pigskin. The accumulation study in rabbit mucosa showed better accumulation of resveratrol NS formulation than plain drug. These results signify that resveratrol NS formulation can be used for buccal delivery and topical application.

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“…There have been a number of recent reviews focusing on the encapsulation of the more widely used polyphenols, discussing their effectiveness, variations, developments and trends (Barras et al, 2009;Das, Ng, 2010;Di Mattia et al, 2009;Dube et al, 2010;Ersus, Yurdagel, 2007;Fang et al, 2006;Hu et al, 2008;Kosaraju, Dath, Lawrence, 2006;Laine et al, 2008;Liang et al, 2011;Lucas-Abellan et al, 2007;Mourtzinos et al, 2007;Shi et al, 2007;Shutava et al, 2009;Tommasini et al, 2005;Zhang, Mou, Du, 2007;Xiong et al, 2006;Yu, Huang, 2010).…”

Section: Introductionmentioning

confidence: 99%

Alginate-pomegranate peels' polyphenols beads: effects of formulation parameters on loading efficiency

Zam

Bashour

Abdelwahed

et al. 2014

Braz. J. Pharm. Sci.

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Calcium alginate beads containing pomegranate peels' polyphenol extract were encapsulated by ionic gelation method. The effects of various formulation factors (sodium alginate concentration, calcium chloride concentration, calcium chloride exposure time, gelling bath time maintaining, and extract concentration) on the efficiency of extract loading were investigated. The formulation containing an extract of 1 g pomegranate peels in 100 mL distilled water encapsulated with 3 % of sodium alginate cured in 0.05 M calcium chloride for 20 minutes and kept in a gelling bath for 15 minutes was chosen as the best formula regarding the loading efficiency. These optimized conditions allowed the encapsulation of 43.90% of total extracted polyphenols and 46.34 % of total extracted proanthocyanidins. Microencapsulation of pomegranate peels' extract in calcium alginate beads is a promising technique for pharmaceutical and food supplementation with natural antioxidants.

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Cyclodextrins as resveratrol carrier system

Cited by 138 publications

References 24 publications

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

Cyclodextrin-Based Nanosponges for Delivery of Resveratrol: In Vitro Characterisation, Stability, Cytotoxicity and Permeation Study

Alginate-pomegranate peels' polyphenols beads: effects of formulation parameters on loading efficiency

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