Cyclodextrins in drug delivery systems

Otero-Espinar, Francisco J.; Torres‐Labandeira, Juan J.; Álvarez-Lorenzo, Carmen; Blanco-Méndez, J.

doi:10.1016/s1773-2247(10)50046-7

Cited by 95 publications

(61 citation statements)

References 179 publications

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“…This strategy has been used to increase the bioavailability of low-water soluble active pharmaceutical ingredients in different conventional forms [46,47]. CDs have been combined also with novel drug delivery systems (e.g., liposomes, microparticles for colon delivery) [48,49] or transformed, by ad hoc functionalization, in supramolecular devices for drug delivery [50,51].…”

Section: Discussionmentioning

confidence: 99%

β-cyclodextrin hinders PLGA plasticization during microparticle manufacturing

Albertini

Iraci

Schoubben

et al. 2015

Journal of Drug Delivery Science and Technology

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Section: Discussionmentioning

confidence: 99%

β-cyclodextrin hinders PLGA plasticization during microparticle manufacturing

Albertini

Iraci

Schoubben

et al. 2015

Journal of Drug Delivery Science and Technology

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“…Besides, CDs are excellent solubilizers and physical and chemical stabilizers, and provide protection to the guest molecules from degradation in the gastrointestinal tract, thereby enhancing drug bioavailability. 181 CDs have been used as a pharmaceutical excipient, mainly to solubilize drugs with poor solubility in an aqueous environment through the synthesis of drug-CD complexes. 182,183 The naturally occurring CDs have been used at a large scale in the evaluation and development of pharmaceutical formulations.…”

Section: Cyclodextrinsmentioning

confidence: 99%

Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Ramos¹,

Silva²,

Spósito³

et al. 2018

IJN

220

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Since the dawn of civilization, it has been understood that pathogenic microorganisms cause infectious conditions in humans, which at times, may prove fatal. Among the different virulent properties of microorganisms is their ability to form biofilms, which has been directly related to the development of chronic infections with increased disease severity. A problem in the elimination of such complex structures (biofilms) is resistance to the drugs that are currently used in clinical practice, and therefore, it becomes imperative to search for new compounds that have anti-biofilm activity. In this context, nanotechnology provides secure platforms for targeted delivery of drugs to treat numerous microbial infections that are caused by biofilms. Among the many applications of such nanotechnology-based drug delivery systems is their ability to enhance the bioactive potential of therapeutic agents. The present study reports the use of important nanoparticles, such as liposomes, microemulsions, cyclodextrins, solid lipid nanoparticles, polymeric nanoparticles, and metallic nanoparticles, in controlling microbial biofilms by targeted drug delivery. Such utilization of these nanosystems has led to a better understanding of their applications and their role in combating biofilms.

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“…A different approach consists of designing synthetic networks with domains capable of mimicking the recognition features of the biological macromolecules. Various semisynthetic ringtype substances, such as crown ethers, cryptates, cyclophanes, or cyclodextrins, can host in their cavity certain molecules forming inclusion complexes [49][50][51][52][53]. The selectivity of the interactions with these materials is conditioned by the size of the cavities and the arrangement of their chemical groups.…”

Section: Molecule-responsive and Imprinted Systemsmentioning

confidence: 99%