Cyclohexane-Fused Octahydroquinolizine Alkaloids from <i>Myrioneuron faberi</i> with Activity against Hepatitis C Virus

Cao, Mingming; Zhang, Yu; Li, Xiaohui; Peng, Zong–Gen; Jiang, Jian‐Dong; Gu, Yu‐Cheng; Di, Ying‐Tong; Li, Xiaonian; Chen, Duo-Zhi; Xia, Chengfeng; He, Hongping; Li, Shun‐Lin; Hao, Xiao‐Jiang

doi:10.1021/jo501076x

Cited by 37 publications

(26 citation statements)

References 27 publications

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“…(Rubiaceae) as a Chinese herbal plant. These cyclohexane-fused octahydroquinolizine alkaloids exhibited inhibitory effects on hepatitis C virus [ 27 ].…”

Section: Antiviral Activities Of Alkaloidsmentioning

confidence: 99%

Alkaloids as Potential Phytochemicals against SARS-CoV-2: Approaches to the Associated Pivotal Mechanisms

Majnooni

Fakhri

Bahrami

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Since its inception, the coronavirus disease 2019 (COVID-19) pandemic has infected millions of people around the world. Therefore, it is necessary to find effective treatments against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), as it is the viral source of COVID-19. Alkaloids are one of the most widespread plant-derived natural compounds with prominent antiviral effects. Accordingly, these phytochemicals have been promising candidates towards discovering effective treatments for COVID-19. Alkaloids have shown potential anti-SARS-CoV activities via inhibiting pathogenesis-associated targets of the Coronaviridae family that are required for the virus life cycle. In the current study, the chemistry, plant sources, and antiviral effects of alkaloids, as well as their anti-SARS-CoV-2 effect with related mechanisms, are reviewed towards discovering an effective treatment against COVID-19.

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“…(Rubiaceae) as a Chinese herbal plant. These cyclohexane-fused octahydroquinolizine alkaloids exhibited inhibitory effects on hepatitis C virus [ 27 ].…”

Section: Antiviral Activities Of Alkaloidsmentioning

confidence: 99%

Alkaloids as Potential Phytochemicals against SARS-CoV-2: Approaches to the Associated Pivotal Mechanisms

Majnooni

Fakhri

Bahrami

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Compounds 28–30 inhibited replication of HCV with IC 50 values of 4.7, 2.2, and 0.9 μM, respectively, and exhibited less cytotoxicity against liver cells than the positive control telaprevir (VX-950). 41 Aloperine ( 1 ), a quinolizidine alkaloid with an unusual endocyclic ring system, was extracted from Sophora alopecuroides . Aloperine has been identified as a potent HCV inhibitor with an EC 50 value of 4.23 ± 0.99 μM.…”

Section: Extracts and Alkaloids From Plants Modulating Viral Infectiomentioning

confidence: 99%

Progress of Plant Medicine Derived Extracts and Alkaloids on Modulating Viral Infections and Inflammation

Ti¹,

Zhuang²,

Yu³

et al. 2021

DDDT

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Viral infectious diseases are serious threats to human health in both developing and developed countries. Although there is the continued development of new drugs from synthetic sources as antiviral agents, medicinal plants continue to provide the basic raw materials for some of the most important antiviral drugs. Alkaloids are a class of pharmacologically active plant compounds that are usually alkaline in nature. In this review, we tried to summarize recent progress in herb-based antiviral research, the advantages of using active plant compounds as antiviral agents, and the inflammatory responses initiated by alkaloids, based on the literature from 2009 to 2019, for the treatment of conditions, including influenza, human immunodeficiency virus, herpes simplex virus, hepatitis, and coxsackievirus infections. Articles are retrieved from PubMed, Google Scholar, and Web of Science using relevant keywords. In particular, the alkaloids from medicinal plants responsible for the molecular mechanisms of anti-inflammatory actions are identified and discussed. This review can provide a theoretical basis and approaches for using various alkaloids as antiviral treatments. More research is needed to develop alkaloidal compounds as antiviral therapeutic agents and potential regulators of the anti-inflammatory response.

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“…(±)‐α,β‐Myrifabrals A and B were isolated as two clusters from Myrioneuron faberi in 2014. [ 24 ] The four new myrioneuron alkaloids possess a novel cyclohexane‐fused octahydroquinolizine skeleton together with a six‐membered cyclic hemiacetal. Preliminary bioactivity test indicated that both clusters exhibited promising anti‐HCV activity (IC 50 0.9 to 4.7 μmol·L –1 ) with cytotoxicity lower than that of telaprevir, a commercial pharmaceutical drug for the treatment of hepatitis C. Due to the very limited natural availability (30 mg A and 2 mg B from 30 kg dried samples), a highly efficient chemical synthesis is desirable for further SAR studies.…”

Section: Short and Scalable Total Syntheses Of Myrioneuron Alkaloidsmentioning

confidence: 99%

Concise Total Syntheses of Bioactive Alkaloids Enabled by Development or Application of Cascade Reactions: A Personnel Adventure

Xie

She

2021

Chin. J. Chem.

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What is the most favorite and original chemistry developed in your research group? Total synthesis of bioactive natural products is the most favorite chemistry in my research group and development or application of new strategies to improve the synthetic efficiency is the most original chemistry developed in my research group. How do you get into this specific field? Could you please share some experiences with our readers? My PhD project was total synthesis of bioactive natural lignans and I devoted myself into synthetic methodology development during my postdoctoral research period. In my opinion, a highly efficient synthetic method will greatly shorten the synthetic route and improve its efficiency for a target-oriented total synthesis. On the other hand, target-oriented total synthesis is the best platform to evaluate the practical value of a synthetic method. So I choose total synthesis of natural products and target-oriented synthetic methodology development as my research fields when I began my independent research. How do you supervise your students? When the students start their projects, I discuss the research subjects with them once a month. Every Saturday night we hold a group meeting to learn and discuss the most recent published literatures related to our research. I give more encouragement when the students meet difficulties in their research. Then we try to solve the difficulties together. What is the most important personality for scientific research? In my view, diligence and persistence are the most important personalities for scientific research. What's your hobby? What's your favorite book(s)? Reading. My favorite book is Sapiens-a brief history of humankind. How do you keep balance between research and family? I usually spend six days (from Monday to Saturday) on research work. On Sunday I will cook some delicious food and enjoy it with my family. My wife understands and supports my work very well. She has done a lot for our family.

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Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus

Cited by 37 publications

References 27 publications

Alkaloids as Potential Phytochemicals against SARS-CoV-2: Approaches to the Associated Pivotal Mechanisms

Alkaloids as Potential Phytochemicals against SARS-CoV-2: Approaches to the Associated Pivotal Mechanisms

Progress of Plant Medicine Derived Extracts and Alkaloids on Modulating Viral Infections and Inflammation

Concise Total Syntheses of Bioactive Alkaloids Enabled by Development or Application of Cascade Reactions: A Personnel Adventure

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