Cycloheximide impairs reconsolidation of a contextually reactivated memory in a conditioned taste aversion paradigm.

Flint, Robert W.; Marino, Christina L.

doi:10.1037/0735-7044.121.2.433

Cited by 16 publications

(17 citation statements)

References 47 publications

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“…That is, do people innately favor certain foods or food textures, or are such food preferences primarily a function of environmental experiences? Moreover, the results from the current study showing that food preference may be easily altered is consistent with the literature in the area of taste aversion which has shown extremely rapid conditioning of food tastes and preferences (Bures et al 1998; Flint and Marino 2007; Miranda et al 2003). Further research along these lines may be profitable in understanding food preferences and in establishing interventions for altering food flexibility and fostering more appropriate nutritional choices.…”

Section: Discussionsupporting

confidence: 92%

Using Individualized Reinforcers and Hierarchical Exposure to Increase Food Flexibility in Children with Autism Spectrum Disorders

Koegel

Bharoocha

Ribnick

et al. 2011

J Autism Dev Disord

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Inflexibility is a major characteristic of autism. In the present study we addressed inflexible mealtime behaviors and collected longitudinal data across 48 foods for 3 children, ages 6.4–7.8 years, diagnosed with autism spectrum disorder, for up to 22 weeks. Participants exhibited severe challenges with adherence to an extremely restricted repertoire of foods. We employed clinical replication and multiple baseline designs across participants to assess the effects of individualized reinforcement and hierarchical exposure to increase flexibility. Results showed that following intervention, all participants expanded their food repertoire and spontaneously requested new foods during follow up/generalization. Implications for clinical practice and directions for further research are discussed.

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Section: Discussionsupporting

confidence: 92%

Using Individualized Reinforcers and Hierarchical Exposure to Increase Food Flexibility in Children with Autism Spectrum Disorders

Koegel

Bharoocha

Ribnick

et al. 2011

J Autism Dev Disord

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“…Cycloheximide (Sigma, St Louis, Missouri) was dissolved in 0.9% saline and administered subcutaneously (s.c.) at 2.2 mg/Kg (28, 29). …”

Section: Methodsmentioning

confidence: 99%

Preclinical Assessment for Selectively Disrupting a Traumatic Memory via Postretrieval Inhibition of Glucocorticoid Receptors

Taubenfeld

Riceberg

New

et al. 2009

Biological Psychiatry

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Background-Traumatic experiences may lead to debilitating psychiatric disorders including acute stress disorder and post-traumatic stress disorder. Current treatments for these conditions are largely ineffective; therefore, novel therapies are needed. A cardinal symptom of these pathologies is the re-experiencing of the trauma through intrusive memories and nightmares. Studies in animal models indicate that memories can be weakened by interfering with the post-retrieval re-stabilization process known as memory reconsolidation. We previously reported that, in rats, intra-amygdala injection of the glucocorticoid receptor antagonist RU38486 disrupts the reconsolidation of a traumatic memory. Here we tested parameters important for designing novel clinical protocols targeting the reconsolidation of a traumatic memory with RU38486.

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“…, 2007; Cochrane et al. , 2007; Flint and Marino, 2007; Goghari et al. , 2007), where effect size values between 0.15 and 0.25 roughly indicated small/moderate effect size, and values larger than 0.25 indicate robust effect size.…”

Section: Methodsmentioning

confidence: 99%

Assessing sleepiness in the rat: a multiple sleep latencies test compared to polysomnographic measures of sleepiness

Mckenna¹,

Cordeira²,

Christie³

et al. 2008

Journal of Sleep Research

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SUMMAR Y Sleepiness following 6 h of sleep deprivation (SD) was evaluated with a rat multiple sleep latencies test (rMSLT), and the findings were compared to conventional polysomnographic measures of sleepiness. The 6 h of SD was produced by automated activity wheels, and was terminated at either the end of the light period or at the beginning of the dark period. The rMSLT consisted of 5 min wakefulness induced by sensory stimulation followed by 25 min of freedom to sleep. This procedure was repeated every 30 min for 3 h and was designed to minimize the amount of sleep lost due to the testing procedure. In separate rats, 6 h SD was followed by undisturbed recovery, allowing evaluation of conventional polysomnographic measures of sleepiness. Sleep onset latencies were reduced following SD, with recovery in the light (baseline = 8 min, 3 s versus post-SD = 1 min, 17 s) and dark period (baseline = 14 min, 17 s versus 7 min, 7 s). Sleep onset latencies were not altered by varying the duration criterion for the first sleep bout (i.e., sleep bout length criteria of 10, 20, 30, or 60 s were compared). Polysomnographic variables (non-rapid eye movement sleep episode duration, delta power, and number of awakenings) also provided reliable indirect measures of sleepiness, regardless of whether the recovery sleep occurred in the light or dark period. Evaluation of effect size indicated that the rMSLT was a strong measure of sleepiness, and was influenced by homeostatic, circadian, and illumination factors. The rMSLT provided a simple, objective, robust and direct measure of sleepiness that was as effective as conventional polysomnographic measures of sleepiness.k e y w o r d s electroencephalogram, non-rapid eye movement, rat, sleep, sleep latency

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Cycloheximide impairs reconsolidation of a contextually reactivated memory in a conditioned taste aversion paradigm.

Cited by 16 publications

References 47 publications

Using Individualized Reinforcers and Hierarchical Exposure to Increase Food Flexibility in Children with Autism Spectrum Disorders

Using Individualized Reinforcers and Hierarchical Exposure to Increase Food Flexibility in Children with Autism Spectrum Disorders

Preclinical Assessment for Selectively Disrupting a Traumatic Memory via Postretrieval Inhibition of Glucocorticoid Receptors

Assessing sleepiness in the rat: a multiple sleep latencies test compared to polysomnographic measures of sleepiness

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