Cycloisomerization and [2+2]cyclodimerization of 1,5-cyclooctadiene catalyzed with the Ni(COD)2/BF3·OEt2 system

Nickel-Catalyzed Directed C6-Selective C–H Alkylation of 2-Pyridones with Dienes and Activated Alkenes

“…The structure of 2a was first assigned by NMR and HRMS and was finally determined by X-ray crystallographic analysis of the major diastereomer after dibromination with dibromohydantoin . Such a ring-contracting coupling with cod is not trivial . Thus, the preliminary but intriguing result in Scheme prompted us to optimize conditions for the unique catalytic C–H alkylation of 2-pyridone with cod as a coupling partner (Table ).…”