Cyclometalated platinum(II) complexes bearing natural arylolefin and quinolines ligands: Synthesis, characterizations, and in vitro cytotoxicity

Thong, Pham Van; Meervelt, Luc Van; Thanh, Nguyễn Thị

doi:10.1016/j.poly.2022.116180

Cited by 1 publication

(1 citation statement)

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“…Recently, many organoplatinum(II) complexes possessing natural arylolefin ligands and either amine or Nheterocyclic carbene have been synthesized with the aim of minimizing toxicity and diversifying hopeful anti-cancer agents. The tested cytotoxicity results show that many of them exhibit higher activity than cisplatin on some human cancer cell lines such as KB, Lu-1, Hep G2 and MCF-7 (Da et al, 2012(Da et al, , 2015Thi Hong Hai et al, 2019;Nguyen Thi Thanh et al, 2017;Chi et al, 2018Chi et al, , 2020Van Thong et al, 2022).…”

Section: Chemical Contextmentioning

confidence: 99%

Synthesis and crystal structures of three organoplatinum(II) complexes bearing natural arylolefin and quinoline derivatives

Chi,

Van Thong,

Thang

et al. 2024

Acta Cryst E

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Three organoplatinum(II) complexes bearing natural arylolefin and quinoline derivatives, namely, [4-methoxy-5-(2-methoxy-2-oxoethoxy)-2-(prop-2-en-1-yl)phenyl](quinolin-8-olato)platinum(II), [Pt(C13H15O4)(C9H6NO)], (I), [4-methoxy-5-(2-oxo-2-propoxyethoxy)-2-(prop-2-en-1-yl)phenyl](quinoline-2-carboxylato)platinum(II), [Pt(C15H19O4)(C10H6NO2)], (II), and chlorido[4-methoxy-5-(2-oxo-2-propoxyethoxy)-2-(prop-2-en-1-yl)phenyl](quinoline)platinum(II), [Pt(C15H19O4)Cl(C9H7N)], (III), were synthesized and structurally characterized by IR and 1H NMR spectroscopy, and by single-crystal X-ray diffraction. The results showed that the cycloplatinated arylolefin coordinates with PtII via the carbon atom of the phenyl ring and the C=Colefinic group. The deprotonated 8-hydroxyquinoline (C9H6NO) and quinoline-2-carboxylic acid (C10H6NO2) coordinate with the PtII atom via the N and O atoms in complexes (I) and (II) while the quinoline (C9H7N) coordinates via the N atom in (III). Moreover, the coordinating N atom in complexes (I)–(III) is in the cis position compared to the C=Colefinic group. The crystal packing is characterized by C—H...π, C—H...O [for (II) and (III)], C—H...Cl [for (III) and π–π [for (I)] interactions.

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