Cyclooxygenase-2 expression in human irradiated uveal melanomas

Özdal, Pınar; Callejo, Sonia; Caissie, Amanda; Edelstein, Chaim; Bakalian, S.; Vianna, Raul N. G.; Burnier, Miguel N.

doi:10.1007/s10792-007-9096-z

Cited by 9 publications

(8 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are in contrast to the study of Ozdal et al (2008), which found a reduction of COX-2 expression in uveal melanomas after plaque radiotherapy.…”

Section: Discussioncontrasting

confidence: 99%

See 1 more Smart Citation

Cyclo‐oxygenase‐2 expression in photon‐radiated and non‐radiated uveal melanomas

Suesskind

Paulsen

Buchgeister

et al. 2010

Acta Ophthalmologica

View full text Add to dashboard Cite

ABSTRACT.Purpose: To determine and compare cyclo-oxygenase-2 (COX-2) expression in photon-radiated and non-radiated malignant uveal melanomas and to analyse the correlation between COX-2 expression and prognosis. Methods: Immunohistochemical staining for COX-2 was performed on 21 uveal melanomas that were endoresected after prior stereotactic radiotherapy with photons and on 22 tumours that were treated by endoresection without prior radiotherapy. COX-2 staining was further analysed in respect to cell type, maximal prominence, time interval between radiotherapy and surgery, apoptotic index (AI), proliferative index (PI) and the development of metastatic disease. Results: There was no difference in COX-2 expression between radiated and non-radiated melanomas (P > 0.15). COX-2 staining correlated with neither the tumour prominence (P > 0.40) nor the AI or the PI (both P > 0.35). Tumours with high COX-2 expression were significantly more likely to develop metastasis (P = 0.022). Conclusion: Radiotherapy with photons does not induce COX-2 expression in malignant melanomas of the uvea. But high COX-2 expression may be a marker for poor prognosis.

show abstract

“…These results are in contrast to the study of Ozdal et al (2008), which found a reduction of COX-2 expression in uveal melanomas after plaque radiotherapy.…”

Section: Discussioncontrasting

confidence: 99%

“…In our study, there was no significant difference in COX-2 expression between photon-radiated and nonradiated uveal melanomas. These results are in contrast to the study of Ozdal et al (2008), which found a reduction of COX-2 expression in uveal melanomas after plaque radiotherapy.…”

Section: Discussioncontrasting

confidence: 99%

Cyclo‐oxygenase‐2 expression in photon‐radiated and non‐radiated uveal melanomas

Suesskind

Paulsen

Buchgeister

et al. 2010

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…The COX-2 staining was shown only in 23/40 (57.5%), 52 2/15 (13.3%) 54 or 50/90 (55.6%). 55 Figueiredo et al 52 demonstrated a correlation of the COX-2 expression with the presence of epithelioid melanoma cells assessed according to Callender classification, which indicates higher cancer invasiveness, whereas no such relationships were found by Mougiakakos et al 55 The differences in evaluation of radiotherapy significance for changes in COX-2 levels in eye melanoma cells in papers 52,54,56 may be because of the effect of radiation on many processes, selection of cases for studies, but it is also likely that the choice of anti-COX-2 antibodies was important.…”

Section: Antibodiesmentioning

confidence: 99%

“…In studies of the COX‐2 expression in human eye melanomas, antibodies specific for fragments located at the C‐terminus of this protein were used . COX‐2 was detectable in almost all cases examined: 29/32 (90.6%), 42/42 (100%), and 17/18 (94.4%) .…”

Section: Possible Causes Of Different Cox‐2 Immunohistochemical Detecmentioning

confidence: 99%

Immunohistochemical detectability of cyclooxygenase‐2 expression in cells of human melanocytic skin lesions: A methodological review

Kuźbicki

Brożyna

2019

J Cutan Pathol

View full text Add to dashboard Cite

Increased cyclooxygenase‐2 (COX‐2) expression is thought to support tumorigenesis through various mechanisms and is analyzed as a potential cancer marker. In 18 studies, COX‐2 expression in melanocytic lesions of human skin was examined immunohistochemically. However, results obtained by individual research groups differ in terms of detection frequency and level of this protein, as well as localization of stained cells within tumor. Possible reasons for the discrepancies are analyzed in this review: the application of different antibodies, the use of standard histopathological sections or tissue microarrays and the analyzes of staining results based on different algorithms. COX‐2 level is significantly lower in nevi than in melanomas, increases gradually with progression of these malignant cancers and reaches the highest values in metastases. These gradual changes in COX‐2 expression appear to be difficult to analyze based only on subjective assessment of staining intensity. The most convergent data were obtained using antibodies for N‐terminal fragments of COX‐2 protein and analyzing results based on calculation of percentage fraction of positive cells. The extent of stained area in specimen thus appears to be more important than the intensity of staining in terms of evaluation of COX‐2 performance as a diagnostic and prognostic marker of cutaneous melanoma.

show abstract

“…In a recent issue of International Ophthalmology, Ozdal et al [1] wrote about cyclooxygenase-2 expression in human irradiated uveal melanomas. They reported that radiotherapy may actually decrease cycloxygenase-2 expression in uveal melanomas.…”

Section: To the Editormentioning

confidence: 99%

Management of uveal melanomas: cycloxygenase-2 as a potential molecular target

Kapoor

2012

Int Ophthalmol

View full text Add to dashboard Cite

Cyclooxygenase-2 expression in human irradiated uveal melanomas

Abstract: In contrast with studies showing an increase of COX-2 expression in other irradiated malignancies, irradiation was not a factor inducing COX-2 in uveal melanomas. Radiotherapy may, moreover, be a factor that reduces COX-2 expression in uveal melanomas.

Cited by 9 publications

References 30 publications

Cyclo‐oxygenase‐2 expression in photon‐radiated and non‐radiated uveal melanomas

Cyclo‐oxygenase‐2 expression in photon‐radiated and non‐radiated uveal melanomas

Immunohistochemical detectability of cyclooxygenase‐2 expression in cells of human melanocytic skin lesions: A methodological review

Management of uveal melanomas: cycloxygenase-2 as a potential molecular target

Contact Info

Product

Resources

About